MG1655
W3110
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Gene Report : surA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Mol Microbiol. 1996;21(4):871-84.
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH.
Missiakas D, Betton JM, Raina S. ( 8878048 )
     Deletion OCR29 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  surA
Related strains
     Strains Search Search strains by gene name:  surA   Search strains by all related name:  surA b0053 ECK0054 JW0052

General information  (Go to Linear View:)
 Gene Name surA  
 Alternative name b0053,ECK0054,JW0052  
 Location, Length 53,416 - 54,702 (  -  ) ;   1.15 min ; 1287 (bp) ,   428 (aa) Go to Linear View
 Product peptidyl-prolyl cis-trans isomerase (PPIase)  
 Operon Name lptD-surA-pdxA-rsmA-apaGH  
 Note survival protein; GO_component: GO:0009279 - cell outer membrane; GO_process: GO:0006457 - protein folding  
 Function phenotype; Not classified  
 Gene Ontology GO:0003755 ; peptidyl-prolyl cis-trans isomerase activity ( surA )
GO:0006457 ; protein folding ( surA )
GO:0016853 ; isomerase activity ( surA )
GO:0042597 ; periplasmic space ( surA )
GO:0051082 ; unfolded protein binding ( surA )
 PID 1786238  
 EC number
  (KEGG Pathway)   		5.2.1.8  
Verified Protein Starts (data compiled from literature and appropriate citations are available from EcoGene)
     EcoGene surA ( EG10985 )  
    Number of removed 0 aa cleaved  
SWISS-PROT  ( Show details )
  botton Entry name(Acc.no) SURA_ECOLI ( P21202 ; P75630; Q8KIP6; Q8KMY0 )
    -  Protein name Survival protein surA precursor  
    -  Synonyms Peptidyl-prolyl cis-trans isomerase surA, EC 5.2.1.8, PPIase, Rotamase C  
    -  Gene name OrderedLocusNames=b0053, c0066, z0062, ECs0058, SF0050, S0052;  

 Linear View (Whole Mode)
View Location
   45.0  –  70.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP surA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain A, Crystallographic Structure Of Sura, A Molecular Chaperone That Facilitates Outer Membrane Porin Folding  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Chaperone surA precursor (Peptidyl-prolyl cis-trans isomerase surA) (PPIase surA) (Rotamase surA)  
         PSI-BLAST Chaperone surA precursor
    nr     (database updated : 2007.02.20 )
         BLAST survival protein [Escherichia coli O157:H7 EDL933]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    PPIC_PPIASE     

Other Cross-Reference
    COG COG0760O 
    EcoCyc surA 

MMBR References
J Bacteriol. 1996;178:1770-1773
SurA assists the folding of Escherichia coli outer membrane proteins.
Lazar, S. W., and R. Kolter.
Mol Microbiol. 1996;21(4):871-84.
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH.
Missiakas D, Betton JM, Raina S. ( 8878048 )
Genes Dev. 1996;10:3170-3182
SurA, a periplasmic protein with peptidyl-prolyl isomerase activity, participates in the assembly of outer membrane porins.
Rouviere, P. E., and C. A. Gross.
J Bacteriol. 1990;172(8):4339-47.
surA, an Escherichia coli gene essential for survival in stationary phase.
Tormo A, Almiron M, Kolter R. ( 2165476 )

Sequences
Amino acid
FASTA format 
0001 MKNWKTLLLG IAMIANTSFA APQVVDKVAA VVNNGVVLES DVDGLMQSVK LNAAQARQQL PDDATLRHQI 
0071 MERLIMDQII LQMGQKMGVK ISDEQLDQAI ANIAKQNNMT LDQMRSRLAY DGLNYNTYRN QIRKEMIISE 
0141 VRNNEVRRRI TILPQEVESL AQQVGNQNDA STELNLSHIL IPLPENPTSD QVNEAESQAR AIVDQARNGA 
0211 DFGKLAIAHS ADQQALNGGQ MGWGRIQELP GIFAQALSTA KKGDIVGPIR SGVGFHILKV NDLRGESKNI 
0281 SVTEVHARHI LLKPSPIMTD EQARVKLEQI AADIKSGKTT FAAAAKEFSQ DPGSANQGGD LGWATPDIFD 
0351 PAFRDALTRL NKGQMSAPVH SSFGWHLIEL LDTRNVDKTD AAQKDRAYRM LMNRKFSEEA ASWMQEQRAS 
0421 AYVKILSN
Nucleotide
FASTA format

View sequence out neighbor 100bp 
-100                                             caagagatgc tgcgttcgaa cattctgccg 
-070 tatcaaaaca ctttgtgatt tgttgattta ccacgtaatc cgcagtgcgg ttaattgaaa tggaaaaagt 
0001 atgaagaact ggaaaacgct gcttctcggt atcgccatga tcgcgaatac cagtttcgct gccccccagg 
0071 tagtcgataa agtcgcagcc gtcgtcaata acggcgtcgt gctggaaagc gacgttgatg gattaatgca 
0141 gtcggtaaaa ctgaacgctg ctcaggcaag gcagcaactt cctgatgacg cgacgctgcg ccaccaaatc 
0211 atggaacgtt tgatcatgga tcaaatcatc ctgcagatgg ggcagaaaat gggagtgaaa atctccgatg 
0281 agcagctgga tcaggcgatt gctaacatcg cgaaacagaa caacatgacg ctggatcaga tgcgcagccg 
0351 tctggcttac gatggactga actacaacac ctatcgtaac cagatccgca aagagatgat tatctctgaa 
0421 gtgcgtaaca acgaggtgcg tcgtcgcatc accatcctgc cgcaggaagt cgaatccctg gcgcagcagg 
0491 tgggtaacca aaacgacgcc agcactgagc tgaacctgag ccacatcctg atcccgctgc cggaaaaccc 
0561 gacctctgat caggtgaacg aagcggaaag ccaggcgcgc gccattgtcg atcaggcgcg taacggcgct 
0631 gatttcggta agctggcgat tgctcattct gccgaccagc aggcgctgaa cggcggccag atgggctggg 
0701 gccgtattca ggagttgccc gggatcttcg cccaggcatt aagcaccgcg aagaaaggcg acattgttgg 
0771 cccgattcgt tccggcgttg gcttccatat tctgaaagtt aacgacctgc gcggcgaaag caaaaatatc 
0841 tcggtgaccg aagttcatgc tcgccatatt ctgctgaaac cgtcgccgat catgactgac gaacaggccc 
0911 gtgtgaaact ggaacagatt gctgctgata tcaagagtgg taaaacgact tttgctgccg cagcgaaaga 
0981 gttctctcag gatccaggct ctgctaacca gggcggcgat ctcggctggg ctacaccaga tattttcgat 
1051 ccggccttcc gtgacgccct gactcgcctg aacaaaggtc aaatgagtgc accggttcac tcttcattcg 
1121 gctggcattt aatcgaactg ctggataccc gtaatgtcga taaaaccgac gctgcgcaga aagatcgtgc 
1191 ataccgcatg ctgatgaacc gtaagttctc ggaagaagca gcaagctgga tgcaggaaca acgtgccagc 
1261 gcctacgtta aaatcctgag caactaatgg ttaaaaccca acgtgttgtg atcactcccg gcgagcccgc 
1331 cgggattggc ccggacttag ttgtccagct tgcacagcgt gagtggccgg tcgaact