|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
|
Deletion
|
OCL44
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
lysA
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
lysA
Search strains by all related name:
lysA b2838 ECK2836 JW2806
|
General information (Go to Linear View: )
|
|
Gene Name
|
lysA
|
|
Alternative name
|
b2838,ECK2836,JW2806
|
|
Location, Length
|
2,975,659 - 2,976,921
(
-
)
;
64.14
min
;
1263
(bp) ,
420
(aa)
|
|
Product
|
diaminopimelate decarboxylase, PLP-binding
|
|
Operon Name
|
lysA
|
|
Note
|
diaminopimelate decarboxylase; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate
|
|
Function
|
enzyme; Amino acid biosynthesis: Lysine
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( lysA )
GO:0005515
;
protein binding ( lysA )
GO:0008652
;
amino acid biosynthetic process ( lysA )
GO:0008836
;
diaminopimelate decarboxylase activity ( lysA )
GO:0009085
;
lysine biosynthetic process ( lysA )
GO:0009089
;
lysine biosynthetic process via diaminopimelate ( lysA )
GO:0016829
;
lyase activity ( lysA )
GO:0016831
;
carboxy-lyase activity ( lysA )
|
|
PID
|
1789203
|
EC number
(KEGG Pathway)
|
4.1.1.20
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
DCDA_ECOLI
(
P00861
)
|
|
- Protein name
|
Diaminopimelate decarboxylase
|
|
- Synonyms
|
EC 4.1.1.20, DAP decarboxylase
|
|
- Gene name
|
Name=lysA; OrderedLocusNames=b2838;
|
|
Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
lysA
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Crystal Structure Of Diaminopimelate Decarboxylase
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
|
BLAST
|
Diaminopimelate decarboxylase
|
|
PSI-BLAST
|
Diaminopimelate decarboxylase
|
|
nr
(database updated :
2007.02.20
)
|
|
BLAST
|
Chain A, Crystal Structure Of Diaminopimelate Decarboxylase
|
|
Pfam 28.0
(database updated :
2015-05
)
|
|
Pfam
|
|
|
PROSITE
|
|
PROSITE
|
CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
ODR_DC_2_1
ODR_DC_2_2
|
|
MMBR References
|
J Mol Biol. 1983;168(2):307-20.
Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. I. Identification of a lysR gene encoding an activator of the lysA gene.
Stragier P, Richaud F, Borne F, Patte JC.
(
6411928
)
|
J Mol Biol. 1983;168(2):321-31.
Regulation of diaminopimelate decarboxylase synthesis in Escherichia coli. II. Nucleotide sequence of the lysA gene and its regulatory region.
Stragier P, Danos O, Patte JC.
(
6350601
)
|
Mol Gen Genet. 1981;182(3):456-61.
Construction of hybrid plasmids containing the lysA gene of Escherichia coli: studies of expression in Escherichia coli and Saccharomyces cerevisiae.
Chenais J, Richaud C, Ronceray J, Cherest H, Surdin-Kerjan Y, Patte JC.
(
6272062
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MPHSLFSTDT DLTAENLLRL PAEFGCPVWV YDAQIIRRQI AALKQFDVVR FAQKACSNIH ILRLMREQGV
0071 KVDSVSLGEI ERALAAGYNP QTHPDDIVFT ADVIDQATLE RVSELQIPVN AGSVDMLDQL GQVSPGHRVW
0141 LRVNPGFGHG HSQKTNTGGE NSKHGIWYTD LPAALDVIQR HHLQLVGIHM HIGSGVDYAH LEQVCGAMVR
0211 QVIEFGQDLQ AISAGGGLSV PYQQGEEAVD TEHYYGLWNA AREQIARHLG HPVKLEIEPG RFLVAQSGVL
0281 ITQVRSVKQM GSRHFVLVDA GFNDLMRPAM YGSYHHISAL AADGRSLEHA PTVETVVAGP LCESGDVFTQ
0351 QEGGNVETRA LPEVKAGDYL VLHDTGAYGA SMSSNYNSRP LLPEVLFDNG QARLIRRRQT IEELLALELL
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 taatccatat catttttgca tagactcgac
-070 ataaatcgat attttttatt ctttttatga tgtggcgtaa tcataaaaaa gcacttatct ggagtttgtt
0001 atgccacatt cactgttcag caccgatacc gatctcaccg ccgaaaatct gctgcgtttg cccgctgaat
0071 ttggctgccc ggtgtgggtc tacgatgcgc aaattattcg tcggcagatt gcagcgctga aacagtttga
0141 tgtggtgcgc tttgcacaga aagcctgttc caatattcat attttgcgct taatgcgtga gcagggcgtg
0211 aaagtggatt ccgtctcgtt aggcgaaata gagcgtgcgt tggcggcggg ttacaatccg caaacgcacc
0281 ccgatgatat tgtttttacg gcagatgtta tcgatcaggc gacgcttgaa cgcgtcagtg aattgcaaat
0351 tccggtgaat gcgggttctg ttgatatgct cgaccaactg ggccaggttt cgccagggca tcgggtatgg
0421 ctgcgcgtta atccggggtt tggtcacgga catagccaaa aaaccaatac cggtggcgaa aacagcaagc
0491 acggtatctg gtacaccgat ctgcccgccg cactggacgt gatacaacgt catcatctgc agctggtcgg
0561 cattcacatg cacattggtt ctggcgttga ttatgcccat ctggaacagg tgtgtggtgc tatggtgcgt
0631 caggtcatcg aattcggtca ggatttacag gctatttctg cgggcggtgg gctttctgtt ccttatcaac
0701 agggtgaaga ggcggttgat accgaacatt attatggtct gtggaatgcc gcgcgtgagc aaatcgcccg
0771 ccatttgggc caccctgtga aactggaaat tgaaccgggt cgcttcctgg tagcgcagtc tggcgtatta
0841 attactcagg tgcggagcgt caaacaaatg gggagccgcc actttgtgct ggttgatgcc gggttcaacg
0911 atctgatgcg cccggcaatg tacggtagtt accaccatat cagtgccctg gcagctgatg gtcgttctct
0981 ggaacacgcg ccaacggtgg aaaccgtcgt cgccggaccg ttatgtgaat cgggcgatgt ctttacccag
1051 caggaagggg gaaatgttga aacccgcgcc ttgccggaag tgaaggcagg tgattatctg gtactgcatg
1121 atacaggggc atatggcgca tcaatgtcat ccaactacaa tagccgtccg ctgttaccag aagttctgtt
1191 tgataatggt caggcgcggt tgattcgccg tcgccagacc atcgaagaat tactggcgct ggaattgctt
1261 taactgcggt tagtcgctgg ttgcatgatg acttgcctcc agcgacggag ttgacactga atgacgacgt
1331 accagcgtcg gactaaagac attagtgatt tcc
|
