MG1655
W3110
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Gene Report : deoA
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Genetika. 1975;11(4):97-105.
[A further study of the nature of phenotypical reversions in thymidine phosphorylase deletion mutants of Escherichia coli K-12]
Mironov AS, Smirnov IuV, Sukhodolets VV. ( 776741 )
     Deletion OCR26 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  deoA
Related strains
     Strains Search Search strains by gene name:  deoA   Search strains by all related name:  deoA b4382 ECK4374 JW4345 TP tpp tpp-75 ttg

General information  (Go to Linear View:)
 Gene Name deoA  
 Alternative name b4382,ECK4374,JW4345,TP,tpp,tpp-75,ttg  
 Location, Length 4,616,252 - 4,617,574 (  +  ) ;   99.50 min ; 1323 (bp) ,   440 (aa) Go to Linear View
 Product thymidine phosphorylase  
 Operon Name deoCABD  
 Note GO_process: GO:0015949 - nucleobase, nucleoside and nucleotide interconversion  
 Function enzyme; Salvage of nucleosides and nucleotides  
 Gene Ontology GO:0005515 ; protein binding ( deoA )
GO:0005624 ; membrane fraction ( deoA )
GO:0006206 ; pyrimidine base metabolic process ( deoA )
GO:0006213 ; pyrimidine nucleoside metabolic process ( deoA )
GO:0008152 ; metabolic process ( deoA )
GO:0009032 ; thymidine phosphorylase activity ( deoA )
GO:0016740 ; transferase activity ( deoA )
GO:0016757 ; transferase activity, transferring glycosyl groups ( deoA )
GO:0016763 ; transferase activity, transferring pentosyl groups ( deoA )
GO:0046104 ; thymidine metabolic process ( deoA )
 PID 1790842  
 EC number
  (KEGG Pathway)
 
2.4.2.4  
SWISS-PROT  ( Show details [ 2 more] )
  botton Entry name(Acc.no) TYPH_ECOLI ( P07650 )
    -  Protein name Thymidine phosphorylase  
    -  Synonyms EC 2.4.2.4, TdRPase  
    -  Gene name Name=deoA; Synonyms=tpp, ttg; OrderedLocusNames=b4382;  

 Linear View (Whole Mode)
View Location
   4605.0  –  4630.0 (KBP)

Homology Analysis
BLAST
    Bacteria
         GTOP deoA (  homologous genes of other bacterias  )  
    PDB     (database updated : 2007.02.20 )
         PSI-BLAST Chain , Thymidine Phosphorylase (E.C.2.4.2.4)  
    SWISS-PROT     (database updated : 2007.02.20 )
         BLAST Thymidine phosphorylase  
         PSI-BLAST Thymidine phosphorylase
    nr     (database updated : 2007.02.20 )
         BLAST thymidine phosphorylase [Escherichia coli K12]  
Pfam 28.0   (database updated : 2015-05 )
    Pfam
PROSITE
    PROSITE GLYCOSAMINOGLYCAN    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AMIDATION    PROKAR_LIPOPROTEIN    THYMID_PHOSPHORYLASE     

Other Cross-Reference
    COG COG0213F 
    EcoCyc deoA 

MMBR References
Gene. 1982;17(3):291-8.
The cloning of the Escherichia coli K-12 deoxyribonucleoside operon.
Fischer M, Short SA. ( 6286410 )
Mol Gen Genet. 1969;104(4):351-9.
A map of four genes specifying enzymes involved in catabolism of nucleosides and deoxynucleosides in Escherichia coli.
Ahmad SI, Pritchard RH. ( 4904508 )
Genetika. 1996;32(1):42-52.
[Unequal crossing over in Escherichia coli: genetic and physical mapping of duplications isolated in conjugational matings]
Sukhodolets VV, Dukhii DE. ( 8647423 )
EMBO J. 1982;1:317-322.
The structure of tandem regulatory regions in the deo operon of Escherichia coli K12.
Valentin-Hansen, P., H. Aiba, and D. Schumperli.
Nucleic Acids Res. 1984;12:5211-5224
The internal regulated promoter of the deo operon of Escherichia coli K-12.
Valentin-Hansen, P., K. Hammer, E. L. Larsen, and I. Svendsen.
EMBO J. 1984;3:179-183
Structure and function of the intercistronic regulatory deoC-deoA element of Escherichia coli K-12.
Valentin-Hansen, P., K. Hammer-Jespersen, F. Boetius, and I. Svendsen.
J Mol Biol. 1979;133(1):1-17.
Evidence for the existence of three promoters for the deo operon of Escherichia coli K12 in vitro.
Valentin-Hansen P, Hammer-Jespersen K, Buxton RS. ( 231107 )

Sequences
Amino acid
FASTA format
0001 MFLAQEIIRK KRDGHALSDE EIRFFINGIR DNTISEGQIA ALAMTIFFHD MTMPERVSLT MAMRDSGTVL 
0071 DWKSLHLNGP IVDKHSTGGV GDVTSLMLGP MVAACGGYIP MISGRGLGHT GGTLDKLESI PGFDIFPDDN 
0141 RFREIIKDVG VAIIGQTSSL APADKRFYAT RDITATVDSI PLITASILAK KLAEGLDALV MDVKVGSGAF 
0211 MPTYELSEAL AEAIVGVANG AGVRTTALLT DMNQVLASSA GNAVEVREAV QFLTGEYRNP RLFDVTMALC 
0281 VEMLISGKLA KDDAEARAKL QAVLDNGKAA EVFGRMVAAQ KGPTDFVENY AKYLPTAMLT KAVYADTEGF 
0351 VSEMDTRALG MAVVAMGGGR RQASDTIDYS VGFTDMARLG DQVDGQRPLA VIHAKDENNW QEAAKAVKAA 
0421 IKLADKAPES TPTVYRRISE 

Nucleotide
FASTA format

View sequence out neighbor 100bp
-100                                             GCGCTTATCA GGCCTACGAG ACGTATCTAC 
-070 CCGTAGGCCG GATAAGGCGT AGACGCATCC GGCAAAAGCC GCCTCATACT CTTTTCCTCG GGAGGTTACC 
0001 ttgtttctcg cacaagaaat tattcgtaaa aaacgtgatg gtcatgcgct gagcgatgaa gaaattcgtt 
0071 tctttatcaa cggtattcgc gacaacacta tctccgaagg gcagattgcc gccctcgcga tgaccatttt 
0141 cttccacgat atgacaatgc ctgagcgtgt ctcgctgacc atggcgatgc gagattcagg aaccgttctc 
0211 gactggaaaa gcctgcatct gaatggcccg attgttgata aacactccac cggtggcgtc ggcgatgtga 
0281 cttcgctgat gttggggccg atggtcgcag cctgcggcgg ctatattccg atgatctctg gtcgcggcct 
0351 cggtcatact ggcggtacgc tcgacaaact ggaatccatc cctggcttcg acattttccc ggatgacaac 
0421 cgtttccgcg aaattattaa agacgtcggc gtggcgatta tcggtcagac cagttcactg gctccggctg 
0491 ataaacgttt ctacgcgacc cgtgatatta ccgcaaccgt ggactccatc ccgctgatca ccgcctctat 
0561 tctggcgaag aaacttgcgg aaggtctgga cgcgctggtg atggacgtga aagtgggtag cggcgcgttt 
0631 atgccgacct acgaactctc tgaagccctt gccgaagcga ttgttggcgt ggctaacggc gctggcgtgc 
0701 gcaccaccgc gctgctcacc gacatgaatc aggtactggc ctccagtgca ggtaacgcgg ttgaagttcg 
0771 tgaagcggtg cagttcctga cgggtgaata tcgtaacccg cgtctgtttg atgtcacgat ggcgctgtgc 
0841 gtggagatgc tgatctccgg caaactggcg aaagatgacg ccgaagcgcg cgcgaaattg caggcggtgc 
0911 tggacaacgg taaagcggca gaagtctttg gtcgtatggt agcggcacaa aaaggcccga ccgacttcgt 
0981 tgagaactac gcgaagtatc tgccgacagc gatgctgacg aaagcagtct atgctgatac cgaaggtttt 
1051 gtcagtgaaa tggatacccg cgcgctgggg atggcagtgg ttgcaatggg cggcggacgc cgtcaggcat 
1121 ctgacaccat cgattacagc gtcggcttta ctgatatggc gcgtctgggc gaccaggtag acggtcagcg 
1191 tccgctggcg gttatccacg cgaaagacga aaacaactgg caggaagcgg cgaaagcggt gaaagcggca 
1261 attaaacttg ccgataaagc accggaaagc acaccaactg tctatcgccg tatcagcgaa taaCGGTATA 
1331 CTGATCTGAT CATTTAAATT TGAAGCACTG AGTACGGAGA ACATATGAAA CGTGCATTTA TTATGGTGCT 
1401 GGACTCATTC GGCATCGGCG CTA