MG1655
W3110
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Gene Report : ftsW
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
Mol Microbiol. 1997;24(6):1263-73.
ftsW is an essential cell-division gene in Escherichia coli.
Boyle DS, Khattar MM, Addinall SG, Lutkenhaus J, Donachie WD. ( 9218774 )
     Deletion OCR30,31-3 (BK2-1 / AK1-1) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  ftsW
Related strains
     Strains Search Search strains by gene name:  ftsW   Search strains by all related name:  ftsW b0089 ECK0090 JW0087

General information  (Go to Linear View:)
 Gene Name ftsW  
 Alternative name b0089,ECK0090,JW0087  
 Location, Length 98,403 - 99,647 (  +  ) ;   2.12 min ; 1245 (bp) ,   414 (aa) Go to Linear View
 Product lipid II flippase; integral membrane protein involved in stabilizing FstZ ring during cell division  
 Operon Name mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC  
 Note cell division; membrane protein involved in shape determination; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane  
 Function membrane; Cell division  
 Gene Ontology GO:0005886; plasma membrane ( ftsW )
GO:0007047; cell wall organization and biogenesis ( ftsW )
GO:0007049; cell cycle ( ftsW )
GO:0008360; regulation of cell shape ( ftsW )
GO:0009252; peptidoglycan biosynthetic process ( ftsW )
GO:0016020; membrane ( ftsW )
GO:0016021; integral to membrane ( ftsW )
GO:0051301; cell division ( ftsW )
 PID 1786277  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) FTSW_ECOLI ( P16457 )
    -  Protein name Cell division protein ftsW.  
    -  Synonyms  
    -  Gene name Name=ftsW; OrderedLocusNames=b0089, c0107, z0099, ECs0093;  
    -  Comments
  • FUNCTION:This is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division.
  • SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
  • SIMILARITY:Belongs to the ftsW/rodA/spoVE family.  

  •  Linear View (Whole Mode)
    View Location
       90.0  –  115.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP ftsW (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
            PSI-BLAST  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Cell division protein ftsW  
             PSI-BLAST Cell division protein ftsW
        nr     (database updated : 2007.02.20 )
             BLAST Cell division protein ftsW [Escherichia coli CFT073]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION    PHOSPHOPANTETHEINE    FTSW_RODA_SPOVE     

    Other Cross-Reference
        EcoCyc ftsW 

    MMBR References
    J Bacteriol. 1989;171(11):6375-8.
    Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.
    Ikeda M, Sato T, Wachi M, Jung HK, Ishino F, Kobayashi Y, Matsuhashi M. ( 2509435 )
    J Bacteriol. 1989;171(11):6379-82.
    Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
    Jung HK, Ishino F, Matsuhashi M. ( 2553679 )
    J Bacteriol. 1994;176:7140-7147
    Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli.
    Khattar, M. M., K. J. Begg, and W. D. Donachie.
    J Bacteriol. 1997;179:784-793
    Two polypeptide products of the Escherichia coli cell division gene ftsW and a possible role for FtsW in FtsZ function.
    Khattar, M. M., S. G. Addinall, K. H. Stedul, D. S. Boyle, J. Lutkenhaus, and W. D. Donachie.

    Sequences
    Amino acid
    FASTA format
    0001 MRLSLPRLKM PRLPGFSILV WISTALKGWV MGSREKDTDS LIMYDRTLLW LTFGLAAIGF IMVTSASMPI 
    0071 GQRLTNDPFF FAKRDGVYLI LAFILAIITL RLPMEFWQRY SATMLLGSII LLMIVLVVGS SVKGASRWID 
    0141 LGLLRIQPAE LTKLSLFCYI ANYLVRKGDE VRNNLRGFLK PMGVILVLAV LLLAQPDLGT VVVLFVTTLA 
    0211 MLFLAGAKLW QFIAIIGMGI SAVVLLILAE PYRIRRVTAF WNPWEDPFGS GYQLTQSLMA FGRGELWGQG 
    0281 LGNSVQKLEY LPEAHTDFIF AIIGEELGYV GVVLALLMVF FVAFRAMSIG RKALEIDHRF SGFLACSIGI 
    0351 WFSFQALVNV GAAAGMLPTK GLTLPLISYG GSSLLIMSTA IMMLLRIDYE TRLEKAQAFV RGSR
    
    
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp
    -100                                             ATATGGTTCT GCTCTCCCCA GCCTGTGCCA 
    -070 GCCTTGATCA GTTCAAGAAC TTTGAACAAC GAGGCAATGA GTTTGCCCGT CTGGCGAAGG AGTTAGGTTG 
    0001 atgcgtttat ctctccctcg cctgaaaatg ccgcgcctgc caggattcag tatcctggtc tggatctcca 
    0071 cggcgctaaa gggctgggtg atgggctcgc gggaaaaaga taccgacagc ctgatcatgt acgatcgcac 
    0141 cttactgtgg ctgaccttcg gcctcgcggc gattggcttt atcatggtga cctcggcgtc aatgcccata 
    0211 gggcaacgct taaccaacga tccgttcttc ttcgcgaagc gtgatggtgt ctatctgatt ttggcgttta 
    0281 ttctggcgat cattacgctg cgtctgccga tggagttctg gcaacgctac agtgccacga tgctgctcgg 
    0351 atctatcatc ctgctgatga tcgtcctggt agtgggtagc tcggttaaag gggcatcgcg ttggatcgat 
    0421 ctcggtttgc tgcgtatcca gcctgcggag ctgacaaaac tgtcgctgtt ttgctatatc gccaactatc 
    0491 tggtgcgtaa aggcgacgaa gtacgtaata acctgcgcgg cttcctgaaa ccgatgggcg tgattctggt 
    0561 gttggcagtg ttactgctgg cacagccaga ccttggtacg gtggtggtgt tgtttgtgac tacgctggcg 
    0631 atgttgttcc tggcgggagc gaaattgtgg cagttcattg ccattatcgg tatgggcatt tcagcggttg 
    0701 tgttgctgat actcgccgaa ccgtaccgta tccgccgtgt taccgcattc tggaacccgt gggaagatcc 
    0771 ctttggcagc ggctatcagt taacgcaatc gctgatggcg tttggtcgcg gcgaactttg ggggcaaggt 
    0841 ttaggtaact cggtacaaaa actggagtat ctgccggaag cgcacactga ctttattttc gccattatcg 
    0911 gcgaagaact ggggtatgtc ggtgtggtgc tggcactttt aatggtattc ttcgtcgctt ttcgcgcgat 
    0981 gtcgattggc cgtaaagcat tagaaattga ccaccgtttt tccggttttc tcgcctgttc tattggcatc 
    1051 tggtttagct tccaggcgct ggttaacgta ggcgcggcgg cggggatgtt accgaccaaa ggtctgacat 
    1121 tgccgctgat cagttacggt ggttcgagct tactgattat gtcgacagcc atcatgatgc tgttgcgtat 
    1191 tgattatgaa acgcgtctgg agaaagcgca ggcgtttgta cgaggttcac gatgaGTGGT CAAGGAAAGC 
    1261 GATTAATGGT GATGGCAGGC GGAACCGGTG GACATGTATT CCCGGGACTG GCGGTTGCGC ACCATCTAAT 
    1331 GGCTCAGGGT TGGCA