MG1655
W3110
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Gene Report : macB
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion OCR50 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  macB
Related strains
     Strains Search Search strains by gene name:  macB   Search strains by all related name:  macB b0879 ECK0870 JW0863 o648 ybjZ

General information  (Go to Linear View:)
 Gene Name macB  
 Alternative name b0879,ECK0870,JW0863,o648,ybjZ  
 Location, Length 919,570 - 921,516 (  +  ) ;   19.82 min ; 1947 (bp) ,   648 (aa) Go to Linear View
 Product fused macrolide transporter subunits of ABCsuperfamily: ATP-binding component/membrane component  
 Operon Name macAB  
 Note GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane  
 Function putative transport; Not classified  
 Gene Ontology GO:0000166 ; nucleotide binding ( macB )
GO:0005524 ; ATP binding ( macB )
GO:0005886 ; plasma membrane ( macB )
GO:0006810 ; transport ( macB )
GO:0016020 ; membrane ( macB )
GO:0016021 ; integral to membrane ( macB )
GO:0016787 ; hydrolase activity ( macB )
GO:0016887 ; ATPase activity ( macB )
GO:0017111 ; nucleoside-triphosphatase activity ( macB )
GO:0042891 ; antibiotic transport ( macB )
GO:0042895 ; antibiotic transporter activity ( macB )
GO:0046677 ; response to antibiotic ( macB )
 PID 1787105  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) MACB_ECOLI ( P75831 )
    -  Protein name Macrolide-specific ABC-type efflux carrier.  
    -  Synonyms  
    -  Gene name Name=macB; OrderedLocusNames=b0879;  
    -  Comments
  • FUNCTION:Efflux transporter for macrolide antibiotics. Acts in conjunction with macA.
  • SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
  • SIMILARITY:Belongs to the ABC transporter family.  
    •   botton Entry name(Acc.no) Q8XED0 ( Q8XED0 )
        -  Protein name Putative ATP-binding component of a transport system.  
        -  Synonyms  
        -  Gene name Name=ybjZ; OrderedLocusNames=z1116;  
        -  Comments
  • SIMILARITY:Belongs to the ABC transporter family.  

    •  Linear View (Whole Mode)
    View Location
       910.0  –  935.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP macB (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Structure Of The Atpase Subunit Cysa Of The Putative Sulfate Atp-Binding Cassette (Abc) Transporter From Alicyclobacillus Acidocaldarius  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Macrolide export ATP-binding/permease protein macB  
             PSI-BLAST Macrolide export ATP-binding/permease protein macB
        nr     (database updated : 2007.02.20 )
             BLAST fused macrolide transporter subunits of ABC superfamily: ATP-binding component/membrane component [Escherichia coli K12]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    GLYCOSAMINOGLYCAN    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    AMIDATION    ATP_GTP_A    ABC_TRANSPORTER     

    Other Cross-Reference
        COG COG0577V  COG1136V 
        EcoCyc macB 

    Sequences
    Amino acid
    FASTA format 
    0001 MTPLLELKDI RRSYPAGDEQ VEVLKGISLD IYAGEMVAIV GASGSGKSTL MNILGCLDKA TSGTYRVAGQ 
0071 DVATLDADAL AQLRREHFGF IFQRYHLLSH LTAEQNVEVP AVYAGLERKQ RLLRAQELLQ RLGLEDRTEY 
0141 YPAQLSGGQQ QRVSIARALM NGGQVILADE PTGALDSHSG EEVMAILHQL RDRGHTVIIV THDPQVAAQA 
0211 ERVIEIRDGE IVRNPPAIEK VNVTGGTEPV VNTVSGWRQF VSGFNEALTM AWRALAANKM RTLLTMLGII 
0281 IGIASVVSIV VVGDAAKQMV LADIRSIGTN TIDVYPGKDF GDDDPQYQQA LKYDDLIAIQ KQPWVASATP 
0351 AVSQNLRLRY NNVDVAASAN GVSGDYFNVY GMTFSEGNTF NQEQLNGRAQ VVVLDSNTRR QLFPHKADVV 
0421 GEVILVGNMP ARVIGVAEEK QSMFGSSKVL RVWLPYSTMS GRVMGQSWLN SITVRVKEGF DSAEAEQQLT 
0491 RLLSLRHGKK DFFTWNMDGV LKTVEKTTRT LQLFLTLVAV ISLVVGGIGV MNIMLVSVTE RTREIGIRMA 
0561 VGARASDVLQ QFLIEAVLVC LVGGALGITL SLLIAFTLQL FLPGWEIGFS PLALLLAFLC STVTGILFGW 
0631 LPARNAARLD PVDALARE
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             TGACGATTGG CGCACGTAAC GATACCGATG 
-070 TTGAGATTGT CAAAGGGCTT GAAGCGGGCG ATGAAGTGGT GATTGGTGAG GCCAAACCAG GAGCTGCACA 
0001 atgacgcctt tgctcgaatt aaaggatatt cgtcgcagct atcctgccgg tgatgagcag gttgaggtgc 
0071 tgaagggcat cagcctcgat atttatgcgg gtgagatggt cgcgattgtt ggcgcttcgg gttccggtaa 
0141 atcgaccctg atgaatattc tcggctgtct ggataaggcc accagcggca cctatcgcgt cgccggtcag 
0211 gatgttgcca cgctggacgc cgatgcgctg gcgcaactgc gccgcgagca tttcggcttt attttccagc 
0281 gttaccattt gctttcgcat ttaaccgccg agcagaacgt tgaagtaccc gccgtctatg ctggtcttga 
0351 gcggaaacag cgactgcttc gtgcccagga gttgctgcaa cggctggggc tggaagaccg tacagagtat 
0421 tatccggcac agctttcggg tggtcagcaa cagcgcgtca gcatcgcgcg ggcattgatg aacggtggtc 
0491 aggtaattct tgccgatgaa ccaaccggcg cactggacag ccattctggc gaagaggtga tggcgatcct 
0561 gcatcagctg cgcgatcgtg ggcatacggt gattatcgtc acccacgatc cgcaggtcgc tgctcaggcc 
0631 gagcgggtga tcgaaattcg cgacggcgaa attgtgcgca atcctcccgc cattgaaaaa gtgaatgtta 
0701 ctggcgggac ggaacctgtt gtcaacacgg tgtctggctg gcggcagttt gtcagcggtt ttaacgaggc 
0771 gctgacgatg gcatggcggg cgctggcagc gaataaaatg cgtactttac tgaccatgct ggggattatt 
0841 atcggtattg cgtcggtggt ttccattgtc gtggtgggtg acgccgccaa acaaatggtg ctggcggata 
0911 ttcgttctat tggtacgaat actattgatg tctatcccgg gaaagatttt ggcgatgacg atccgcaata 
0981 tcagcaggcg ctgaagtacg acgacttaat cgccatccaa aaacaaccgt gggtcgcctc agccacacct 
1051 gccgtctcgc aaaacctgcg cctgcgttat aacaatgttg atgttgctgc cagtgccaat ggcgtgagcg 
1121 gcgattattt taatgtctat ggcatgacct tcagtgaagg aaacaccttt aatcaggagc agctgaacgg 
1191 tcgtgcgcag gtcgtggttc tcgacagtaa tactcgccgc cagcttttcc cccataaagc agatgtggtt 
1261 ggcgaggtga ttctggtcgg caatatgccc gccagagtca ttggtgtggc ggaagaaaaa cagtcgatgt 
1331 ttggtagcag taaagtgctg cgtgtctggc taccttacag cacgatgtcc gggcgagtta tgggccagtc 
1401 gtggcttaac tccattactg tcagggtgaa agaaggattt gacagcgccg aggcggaaca gcaactcacg 
1471 cgtttacttt cactgcgcca cggaaagaag gatttcttta cctggaacat ggacggcgtc ttgaaaactg 
1541 ttgaaaagac cacacgtact ttacaactgt ttctgacgct ggtggcggtg atttcgctgg tggtgggcgg 
1611 tattggtgta atgaatatta tgctggtgtc agtgaccgag cggacgcggg aaattggcat tcgcatggct 
1681 gtaggtgcgc gagcaagcga tgttttgcaa cagttcctga tcgaagccgt actggtttgc ctggtcggtg 
1751 gcgcgttggg aataacactg tcactgttaa ttgctttcac cttgcagctt ttcttacccg gctgggagat 
1821 tggtttttca ccgttggcgc tgctgctggc gtttctctgc tcgacggtca ccgggatttt atttggctgg 
1891 ttacccgcac gaaatgcggc acgactggat ccagtagatg ctctggcacg agagtaaTTT TTGAGATAAA 
1961 AATGCCAGCC GATCGGGCTG GCATTTTGCC TTTAGGATGT ACACAATGAG ACAGAAGAGC TATGCGACTG 
2031 CCGCTTCTAC TTCGACG