MG1655
W3110
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Gene Report : sdhD
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion DE(pgl-grxA)502  ,  OCR48,49-12 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  sdhD
Related strains
     Strains Search Search strains by gene name:  sdhD   Search strains by all related name:  sdhD b0722 ECK0711 JW0712

General information  (Go to Linear View:)
 Gene Name sdhD  
 Alternative name b0722,ECK0711,JW0712  
 Location, Length 754,783 - 755,130 (  +  ) ;   16.27 min ; 348 (bp) ,   115 (aa) Go to Linear View
 Product succinate dehydrogenase, membrane subunit, binds cytochrome b556  
 Operon Name sdhCDAB-sucABCD  
 Note succinate dehydrogenase, hydrophobic subunit; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006099 - tricarboxylic acid cycle; GO_process: GO:0009060 - aerobic respiration  
 Function enzyme; Energy metabolism, carbon: TCA cycle  
 Gene Ontology GO:0005506 ; iron ion binding ( sdhD )
GO:0005886 ; plasma membrane ( sdhD )
GO:0006099 ; tricarboxylic acid cycle ( sdhD )
GO:0006118 ; electron transport ( sdhD )
GO:0006810 ; transport ( sdhD )
GO:0016020 ; membrane ( sdhD )
GO:0016021 ; integral to membrane ( sdhD )
GO:0046872 ; metal ion binding ( sdhD )
 PID 1786941  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) DHSD_ECOLI ( P10445 )
    -  Protein name Succinate dehydrogenase hydrophobic membrane anchor protein.  
    -  Synonyms  
    -  Gene name Name=sdhD; OrderedLocusNames=b0722, c0800, SF0575, S0588;  
    -  Comments
  • FUNCTION:This is the hydrophobic component of the succinate dehydrogenase complex. It is suggested that it is required to anchor the catalytic components to the cytoplasmic membrane.
  • PATHWAY:Tricarboxylic acid cycle.
  • SUBUNIT:Part of an enzyme complex containing four subunits:a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
  • SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.  
  •   botton Entry name(Acc.no) Q8X9A9 ( Q8X9A9 )
        -  Protein name Succinate dehydrogenase, hydrophobic subunit.  
        -  Synonyms  
        -  Gene name Name=sdhD; OrderedLocusNames=z0876;  
        -  Comments
  • SIMILARITY:Belongs to the secA family.  

  •  Linear View (Whole Mode)
    View Location
       745.0  –  770.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP sdhD (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain D, Complex Ii (Succinate Dehydrogenase) From E. Coli With Ubiquinone Bound  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Succinate dehydrogenase hydrophobic membrane anchor protein  
             PSI-BLAST Succinate dehydrogenase hydrophobic membrane anchor protein
        nr     (database updated : 2007.02.20 )
             BLAST succinate dehydrogenase cytochrome b556 small membrane subunit [Escherichia coli K12]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    CK2_PHOSPHO_SITE     

    Other Cross-Reference
        COG COG2142C 
        EcoCyc sdhD 

    MMBR References
    Mol Microbiol. 1995;15(3):473-82.
    Regulation of succinate dehydrogenase (sdhCDAB) operon expression in Escherichia coli in response to carbon supply and anaerobiosis: role of ArcA and Fnr.
    Park SJ, Tseng CP, Gunsalus RP. ( 7783618 )
    J Gen Microbiol. 1986;132(12):3239-51.
    Transcript analysis of the citrate synthase and succinate dehydrogenase genes of Escherichia coli K12.
    Wilde RJ, Guest JR. ( 3309132 )
    Biochem J. 1984;222(2):519-34.
    Nucleotide sequence encoding the flavoprotein and hydrophobic subunits of the succinate dehydrogenase of Escherichia coli.
    Wood D, Darlison MG, Wilde RJ, Guest JR. ( 6383359 )
    J Bacteriol. 1991;173(5):1569-70.
    E. coli map. Physical map locations of genes encoding components of the aerobic respiratory chain of Escherichia coli.
    Calhoun MW, Newton G, Gennis RB. ( 1847904 )

    Sequences
    Amino acid
    FASTA format
    0001 MVSNASALGR NGVHDFILVR ATAIVLTLYI IYMVGFFATS GELTYEVWIG FFASAFTKVF TLLALFSILI 
    0071 HAWIGMWQVL TDYVKPLALR LMLQLVIVVA LVVYVIYGFV VVWGV
    
    
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp
    -100                                             ATTTTGGCTA TCTGGAAGAA ACATTCGAAG 
    -070 CGGGTAAACG CTCCGCCAAA ATCTCCTTTG TTATTACTGT CGTGCTTTCA CTTCTCGCAG GAGTCCTCGT 
    0001 atggtaagca acgcctccgc attaggacgc aatggcgtac atgatttcat cctcgttcgc gctaccgcta 
    0071 tcgtcctgac gctctacatc atttatatgg tcggtttttt cgctaccagt ggcgagctga catatgaagt 
    0141 ctggatcggt ttcttcgcct ctgcgttcac caaagtgttc accctgctgg cgctgttttc tatcttgatc 
    0211 catgcctgga tcggcatgtg gcaggtgttg accgactacg ttaaaccgct ggctttgcgc ctgatgctgc 
    0281 aactggtgat tgtcgttgca ctggtggttt acgtgattta tggattcgtt gtggtgtggg gtgtgtgaTG 
    0351 AAATTGCCAG TCAGAGAATT TGATGCAGTT GTGATTGGTG CCGGTGGCGC AGGTATGCGC GCGGCGCTGC 
    0421 AAATTTCCCA GAGCGGCCAG ACCTGTGC