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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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DE(pgl-grxA)502
,
OCR48,49-12
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
sdhC
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Related strains
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Strains Search
|
Search strains by gene name:
sdhC
Search strains by all related name:
sdhC b0721 cybA ECK0710 JW0711
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General information (Go to Linear View: )
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Gene Name
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sdhC
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Alternative name
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b0721,cybA,ECK0710,JW0711
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Location, Length
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754,400 - 754,789
(
+
)
;
16.26
min
;
390
(bp) ,
129
(aa)
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Product
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succinate dehydrogenase, membrane subunit, binds cytochrome b556
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Operon Name
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sdhCDAB-sucABCD
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Note
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succinate dehydrogenase, cytochrome b556; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006099 - tricarboxylic acid cycle; GO_process: GO:0009060 - aerobic respiration; GO_process: GO:0017004 - cytochrome complex assembly
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Function
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enzyme; Energy metabolism, carbon: TCA cycle
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Gene Ontology
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GO:0000104
;
succinate dehydrogenase activity ( sdhC )
GO:0005506
;
iron ion binding ( sdhC )
GO:0005886
;
plasma membrane ( sdhC )
GO:0006099
;
tricarboxylic acid cycle ( sdhC )
GO:0006118
;
electron transport ( sdhC )
GO:0006810
;
transport ( sdhC )
GO:0016020
;
membrane ( sdhC )
GO:0016021
;
integral to membrane ( sdhC )
GO:0046872
;
metal ion binding ( sdhC )
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PID
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1786940
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
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DHSC_ECOLI
(
P10446
)
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- Protein name
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Succinate dehydrogenase cytochrome b-556 subunit.
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- Synonyms
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- Gene name
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Name=sdhC; Synonyms=cybA; OrderedLocusNames=b0721, z0875, ECs0746;
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- Comments
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FUNCTION:Mono-heme cytochrome of the succinate dehydrogenase complex.
PATHWAY:Tricarboxylic acid cycle.
SUBUNIT:Part of an enzyme complex containing four subunits:a flavoprotein, an iron-sulfur, cytochrome b-556, and an hydrophobic anchor protein.
SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
MISCELLANEOUS:His-84 provides an axial ligand to heme b556 in the wild-type enzyme. The retention of low spin heme b556 in the sdhC Leu-84 mutant suggests that swapping of the heme axial ligand by His-91 or His-30 is possible.
SIMILARITY:Belongs to the cytochrome b560 family.
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Entry name(Acc.no)
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Q8FJU1
(
Q8FJU1
)
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- Protein name
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Succinate dehydrogenase cytochrome b-556 subunit.
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- Synonyms
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- Gene name
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Name=sdhC; OrderedLocusNames=c0798;
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- Comments
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SIMILARITY:Belongs to the 2-oxoacid dehydrogenase family.
SIMILARITY:Contains 1 lipoyl-binding domain.
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MMBR References
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Mol Gen Genet. 1984;196(1):1-5.
Chromosomal location of the Escherichia coli cytochrome b556 gene, cybA.
Murakami H, Kita K, Oya H, Anraku Y.
(
6237244
)
|
FEMS Microbiol Lett. 1985;30:307-311.
The Escherichia coli cytochrome b556 gene, cybA, is assignable as sdhC in the succinate dehydrogenase gene cluster.
Murakami, H., K. Kita, H. Oya, and Y. Anraku.
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Mol Microbiol. 1995;15(3):473-82.
Regulation of succinate dehydrogenase (sdhCDAB) operon expression in Escherichia coli in response to carbon supply and anaerobiosis: role of ArcA and Fnr.
Park SJ, Tseng CP, Gunsalus RP.
(
7783618
)
|
J Bacteriol. 1991;173(5):1569-70.
E. coli map. Physical map locations of genes encoding components of the aerobic respiratory chain of Escherichia coli.
Calhoun MW, Newton G, Gennis RB.
(
1847904
)
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| Sequences |
Amino acid
FASTA format
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0001 MIRNVKKQRP VNLDLQTIRF PITAIASILH RVSGVITFVA VGILLWLLGT SLSSPEGFEQ ASAIMGSFFV
0071 KFIMWGILTA LAYHVVVGIR HMMMDFGYLE ETFEAGKRSA KISFVITVVL SLLAGVLVW
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 GACCGGAGGA AGGAAATCCC GACGTCTCCA
-070 GGTAACAGAA AGTTAACCTC TGTGCCCGTA GTCCCCAGGG AATAATAAGA ACAGCATGTG GGCGTTATTC
0001 atgataagaa atgtgaaaaa acaaagacct gttaatctgg acctacagac catccggttc cccatcacgg
0071 cgatagcgtc cattctccat cgcgtttccg gtgtgatcac ctttgttgca gtgggcatcc tgctgtggct
0141 tctgggtacc agcctctctt cccctgaagg tttcgagcaa gcttccgcga ttatgggcag cttcttcgtc
0211 aaatttatca tgtggggcat ccttaccgct ctggcgtatc acgtcgtcgt aggtattcgc cacatgatga
0281 tggattttgg ctatctggaa gaaacattcg aagcgggtaa acgctccgcc aaaatctcct ttgttattac
0351 tgtcgtgctt tcacttctcg caggagtcct cgtatggtaa GCAACGCCTC CGCATTAGGA CGCAATGGCG
0421 TACATGATTT CATCCTCGTT CGCGCTACCG CTATCGTCCT GACGCTCTAC ATCATTTATA TGGTCGGTTT
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