MG1655
W3110
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Gene Report : fepC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion OCR44,45-2 (LD 12-1_P/O) (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  fepC
Related strains
     Strains Search Search strains by gene name:  fepC   Search strains by all related name:  fepC b0588 ECK0581 JW0580

General information  (Go to Linear View:)
 Gene Name fepC  
 Alternative name b0588,ECK0581,JW0580  
 Location, Length 618,607 - 619,422 (  -  ) ;   13.33 min ; 816 (bp) ,   271 (aa) Go to Linear View
 Product iron-enterobactin transporter subunit  
 Operon Name fepDGC  
 Note ATP-binding component of ferric enterobactin transport; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0006826 - iron ion transport  
 Function transport; Transport of small molecules: Cations  
 Gene Ontology GO:0000166 ; nucleotide binding ( fepC )
GO:0005506 ; iron ion binding ( fepC )
GO:0005524 ; ATP binding ( fepC )
GO:0005886 ; plasma membrane ( fepC )
GO:0006810 ; transport ( fepC )
GO:0006811 ; ion transport ( fepC )
GO:0006826 ; iron ion transport ( fepC )
GO:0016020 ; membrane ( fepC )
GO:0016887 ; ATPase activity ( fepC )
GO:0017111 ; nucleoside-triphosphatase activity ( fepC )
 PID 1786803  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) FEPC_ECOLI ( P23878 ; P75724; P77096 )
    -  Protein name Ferric enterobactin transport ATP-binding protein fepC.  
    -  Synonyms  
    -  Gene name Name=fepC; OrderedLocusNames=b0588;  
    -  Comments
  • FUNCTION:Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system.
  • SUBCELLULAR LOCATION:Inner membrane-associated (Potential).
  • SIMILARITY:Belongs to the ABC transporter family.  
  •   botton Entry name(Acc.no) Q8FK23 ( Q8FK23 )
        -  Protein name Ferric enterobactin transport ATP-binding protein fepC.  
        -  Synonyms  
        -  Gene name Name=fepC; OrderedLocusNames=c0675;  
        -  Comments
  • SIMILARITY:Belongs to the ABC transporter family.  
  •   botton Entry name(Acc.no) Q8XBV7 ( Q8XBV7 )
        -  Protein name ATP-binding component of ferric enterobactin transport.  
        -  Synonyms  
        -  Gene name Name=fepC; OrderedLocusNames=z0729;  
        -  Comments
  • SIMILARITY:Belongs to the ABC transporter family.  

  •  Linear View (Whole Mode)
    View Location
       610.0  –  635.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP fepC (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Crystal Structure Of The Atp-Binding Cassette Of Multisugar Transporter From Pyrococcus Horikoshii Ot3 Complexed With Atp  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Ferric enterobactin transport ATP-binding protein fepC  
             PSI-BLAST Phosphate import ATP-binding protein pstB
        nr     (database updated : 2007.02.20 )
             BLAST ferric enterobactin transport ATP-binding protein [Escherichia coli]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    CK2_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    ABC_TRANSPORTER     

    Other Cross-Reference
        COG COG1120PH 
        EcoCyc fepC 

    MMBR References
    J Bacteriol. 1987;169(8):3638-46.
    Genetic organization of multiple fep genes encoding ferric enterobactin transport functions in Escherichia coli.
    Ozenberger BA, Nahlik MS, McIntosh MA. ( 2956250 )
    J Bacteriol. 1989;171(2):775-83.
    Nucleotide sequence of Escherichia coli isochorismate synthetase gene entC and evolutionary relationship of isochorismate synthetase and other chorismate-utilizing enzymes.
    Ozenberger BA, Brickman TJ, McIntosh MA. ( 2536681 )
    J Bacteriol. 1986;166(3):930-6.
    Escherichia coli K-12 envelope proteins specifically required for ferrienterobactin uptake.
    Pierce JR, Earhart CF. ( 3011753 )
    Mol Microbiol. 1991;5(6):1415-28.
    Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli.
    Shea CM, McIntosh MA. ( 1838574 )

    Sequences
    Amino acid
    FASTA format
    0001 MTESVARLRG EQLTLGYGKY TVAENLTVEI PDGHFTAIIG PNGCGKSTLL RTLSRLMTPA HGHVWLDGEH 
    0071 IQHYASKEVA RRIGLLAQNA TTPGDITVQE LVARGRYPHQ PLFTRWRKED EEAVTKAMQA TGITHLADQS 
    0141 VDTLSGGQRQ RAWIAMVLAQ ETAIMLLDEP TTWLDISHQI DLLELLSELN REKGYTLAAV LHDLNQACRY 
    0211 ASHLIALREG KIVAQGAPKE IVTAELIERI YGLRCMIIDD PVAGTPLVVP LGRTAPSTAN S
    
    
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp
    -100                                             aacaactgtt tatgccgtat caacttccgg 
    -070 ttggcgtcgt taccgtcagc ctcggcggta tttaccttat cgtcttgtta attcaggagt ctcgcaaaaa 
    0001 atgaccgaat cagtagcccg tttgcgcggc gaacagttaa ccctgggata tggcaaatat accgttgcgg 
    0071 aaaatctgac tgtagaaata cctgatggtc acttcacggc aattatcggg ccaaatggct gcggtaaatc 
    0141 cacgttactg cgtaccttaa gccgcctgat gacgcctgct catgggcatg tctggctgga tggcgagcac 
    0211 attcaacatt acgccagtaa agaggttgca cgccggattg gtctgttggc gcaaaatgct accacgccgg 
    0281 gcgatatcac cgtgcaggag ctggtggcgc gtggacgtta tccgcatcaa ccgctgttta cccgctggcg 
    0351 caaagaggat gaagaagcgg taacgaaagc aatgcaggcc acgggaataa ctcatctggc agatcaaagc 
    0421 gtggataccc tttctggcgg acaacgccag cgagcgtgga tcgcgatggt gctggcccag gaaacggcaa 
    0491 ttatgctgct cgacgaaccc acgacctggc tggatatcag tcatcagatt gatttgctgg agttgttaag 
    0561 cgaactgaac cgcgaaaaag gctataccct ggcggcggtg ctgcacgatc ttaatcaggc ctgtcgttac 
    0631 gccagccatt tgattgcatt gcgggaaggg aaaattgttg ctcagggagc gccgaaggag attgtcactg 
    0701 ctgaactgat tgagcgcatt tatggtctgc gctgcatgat cattgacgat ccagttgccg gaacgccgct 
    0771 tgtggtgccg ctcggacgaa cggcaccttc aaccgcaaat agttaaacta agtggtctgc catcatggca 
    0841 tcctgttttc tggatgccat cgcatagcgc aacagcacgc caccacaagc caccatcccg ccgatcaacg 
    0911 cggaaa