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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
|
Mol Microbiol. 1996;21(4):871-84.
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH.
Missiakas D, Betton JM, Raina S.
(
8878048
)
|
|
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Deletion
|
OCR29
(D)
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Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
surA
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Related strains
|
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Strains Search
|
Search strains by gene name:
surA
Search strains by all related name:
surA b0053 ECK0054 JW0052
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General information (Go to Linear View: )
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Gene Name
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surA
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Alternative name
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b0053,ECK0054,JW0052
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Location, Length
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53,416 - 54,702
(
-
)
;
1.15
min
;
1287
(bp) ,
428
(aa)
|
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Product
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peptidyl-prolyl cis-trans isomerase (PPIase)
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Operon Name
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lptD-surA-pdxA-rsmA-apaGH
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Note
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survival protein; GO_component: GO:0009279 - cell outer membrane; GO_process: GO:0006457 - protein folding
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Function
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phenotype; Not classified
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Gene Ontology
|
GO:0003755
;
peptidyl-prolyl cis-trans isomerase activity ( surA )
GO:0006457
;
protein folding ( surA )
GO:0016853
;
isomerase activity ( surA )
GO:0042597
;
periplasmic space ( surA )
GO:0051082
;
unfolded protein binding ( surA )
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PID
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1786238
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EC number
(KEGG Pathway)
|
5.2.1.8
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Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
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EcoGene
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surA
(
EG10985
)
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Number of removed
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0 aa cleaved
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
|
SURA_ECOLI
(
P21202
;
P75630; Q8KIP6; Q8KMY0
)
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- Protein name
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Survival protein surA precursor
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- Synonyms
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Peptidyl-prolyl cis-trans isomerase surA, EC 5.2.1.8, PPIase, Rotamase C
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- Gene name
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OrderedLocusNames=b0053, c0066, z0062, ECs0058, SF0050, S0052;
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- Comments
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FUNCTION:Assist in the folding of extracytoplasmic proteins. Essential for the survival of E.coli in stationary phase.
CATALYTIC ACTIVITY:Peptidylproline (omega=180) = peptidylproline (omega=0).
SUBCELLULAR LOCATION:Periplasmic.
SIMILARITY:Belongs to the ppiC/parvulin rotamase family.
CAUTION:Ref.2 sequence differs from that shown due to a frameshift in position 156.
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MMBR References
|
J Bacteriol. 1996;178:1770-1773
SurA assists the folding of Escherichia coli outer membrane proteins.
Lazar, S. W., and R. Kolter.
|
Mol Microbiol. 1996;21(4):871-84.
New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH.
Missiakas D, Betton JM, Raina S.
(
8878048
)
|
Genes Dev. 1996;10:3170-3182
SurA, a periplasmic protein with peptidyl-prolyl isomerase activity, participates in the assembly of outer membrane porins.
Rouviere, P. E., and C. A. Gross.
|
J Bacteriol. 1990;172(8):4339-47.
surA, an Escherichia coli gene essential for survival in stationary phase.
Tormo A, Almiron M, Kolter R.
(
2165476
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MKNWKTLLLG IAMIANTSFA APQVVDKVAA VVNNGVVLES DVDGLMQSVK LNAAQARQQL PDDATLRHQI
0071 MERLIMDQII LQMGQKMGVK ISDEQLDQAI ANIAKQNNMT LDQMRSRLAY DGLNYNTYRN QIRKEMIISE
0141 VRNNEVRRRI TILPQEVESL AQQVGNQNDA STELNLSHIL IPLPENPTSD QVNEAESQAR AIVDQARNGA
0211 DFGKLAIAHS ADQQALNGGQ MGWGRIQELP GIFAQALSTA KKGDIVGPIR SGVGFHILKV NDLRGESKNI
0281 SVTEVHARHI LLKPSPIMTD EQARVKLEQI AADIKSGKTT FAAAAKEFSQ DPGSANQGGD LGWATPDIFD
0351 PAFRDALTRL NKGQMSAPVH SSFGWHLIEL LDTRNVDKTD AAQKDRAYRM LMNRKFSEEA ASWMQEQRAS
0421 AYVKILSN
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 caagagatgc tgcgttcgaa cattctgccg
-070 tatcaaaaca ctttgtgatt tgttgattta ccacgtaatc cgcagtgcgg ttaattgaaa tggaaaaagt
0001 atgaagaact ggaaaacgct gcttctcggt atcgccatga tcgcgaatac cagtttcgct gccccccagg
0071 tagtcgataa agtcgcagcc gtcgtcaata acggcgtcgt gctggaaagc gacgttgatg gattaatgca
0141 gtcggtaaaa ctgaacgctg ctcaggcaag gcagcaactt cctgatgacg cgacgctgcg ccaccaaatc
0211 atggaacgtt tgatcatgga tcaaatcatc ctgcagatgg ggcagaaaat gggagtgaaa atctccgatg
0281 agcagctgga tcaggcgatt gctaacatcg cgaaacagaa caacatgacg ctggatcaga tgcgcagccg
0351 tctggcttac gatggactga actacaacac ctatcgtaac cagatccgca aagagatgat tatctctgaa
0421 gtgcgtaaca acgaggtgcg tcgtcgcatc accatcctgc cgcaggaagt cgaatccctg gcgcagcagg
0491 tgggtaacca aaacgacgcc agcactgagc tgaacctgag ccacatcctg atcccgctgc cggaaaaccc
0561 gacctctgat caggtgaacg aagcggaaag ccaggcgcgc gccattgtcg atcaggcgcg taacggcgct
0631 gatttcggta agctggcgat tgctcattct gccgaccagc aggcgctgaa cggcggccag atgggctggg
0701 gccgtattca ggagttgccc gggatcttcg cccaggcatt aagcaccgcg aagaaaggcg acattgttgg
0771 cccgattcgt tccggcgttg gcttccatat tctgaaagtt aacgacctgc gcggcgaaag caaaaatatc
0841 tcggtgaccg aagttcatgc tcgccatatt ctgctgaaac cgtcgccgat catgactgac gaacaggccc
0911 gtgtgaaact ggaacagatt gctgctgata tcaagagtgg taaaacgact tttgctgccg cagcgaaaga
0981 gttctctcag gatccaggct ctgctaacca gggcggcgat ctcggctggg ctacaccaga tattttcgat
1051 ccggccttcc gtgacgccct gactcgcctg aacaaaggtc aaatgagtgc accggttcac tcttcattcg
1121 gctggcattt aatcgaactg ctggataccc gtaatgtcga taaaaccgac gctgcgcaga aagatcgtgc
1191 ataccgcatg ctgatgaacc gtaagttctc ggaagaagca gcaagctgga tgcaggaaca acgtgccagc
1261 gcctacgtta aaatcctgag caactaatgg ttaaaaccca acgtgttgtg atcactcccg gcgagcccgc
1331 cgggattggc ccggacttag ttgtccagct tgcacagcgt gagtggccgg tcgaact
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