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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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J Bacteriol. 1993;175(21):6925-31.
Nucleotide sequence and 3'-end deletion studies indicate that the K(+)-uptake protein kup from Escherichia coli is composed of a hydrophobic core linked to a large and partially essential hydrophilic C terminus.
Schleyer M, Bakker EP.
(
8226635
)
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Deletion
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OCR01-1
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
kup
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Related strains
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Strains Search
|
Search strains by gene name:
kup
Search strains by all related name:
kup b3747 ECK3741 JW5609 trkD
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General information (Go to Linear View: )
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Gene Name
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kup
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Alternative name
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b3747,ECK3741,JW5609,trkD
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Location, Length
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3,929,339 - 3,931,207
(
+
)
;
84.69
min
;
1869
(bp) ,
622
(aa)
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Product
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potassium transporter
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Operon Name
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kup
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Note
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low affinity potassium transport system; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006970 - response to osmotic stress
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Function
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transport; Transport of small molecules: Cations
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Gene Ontology
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GO:0005886
;
plasma membrane ( kup )
GO:0006810
;
transport ( kup )
GO:0006811
;
ion transport ( kup )
GO:0006813
;
potassium ion transport ( kup )
GO:0015079
;
potassium ion transmembrane transporter activity ( kup )
GO:0015293
;
symporter activity ( kup )
GO:0016020
;
membrane ( kup )
GO:0016021
;
integral to membrane ( kup )
GO:0030955
;
potassium ion binding ( kup )
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PID
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48994960
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
|
KUP_ECOLI
(
P30016
;
P76748
)
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- Protein name
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Low affinity potassium transport system protein kup
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- Synonyms
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Kup system potassium uptake protein
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- Gene name
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Name=kup; Synonyms=trkD; OrderedLocusNames=b3747, c4675;
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- Comments
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FUNCTION:Low-affinity potassium transporter.
SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
SIMILARITY:Belongs to the HAK/KUP transporter (TC 2.A.72) family.
CAUTION:Ref.2 sequence differs from that shown due to frameshifts in positions 506, 542 and 579.
CAUTION:Ref.3 sequence differs from that shown due to frameshifts in positions 506 and 542.
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Entry name(Acc.no)
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KUP_ECO57
(
Q8XAW9
)
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- Protein name
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Low affinity potassium transport system protein kup
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- Synonyms
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Kup system potassium uptake protein
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- Gene name
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Name=kup; Synonyms=trkD; OrderedLocusNames=z5248, ECs4689;
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- Comments
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FUNCTION:Low-affinity potassium transporter (By similarity).
SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane (By similarity).
SIMILARITY:Belongs to the HAK/KUP transporter (TC 2.A.72) family.
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MMBR References
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J Bacteriol. 1971;108(2):639-44.
Potassium transport loci in Escherichia coli K-12.
Epstein W, Kim BS.
(
4942756
)
|
J Bacteriol. 1993;175:6925-6931
Nucleotide sequence and 3'-end deletion studies indicate that the K(+)-uptake protein Kup from Escherichia coli is composed of a hydrophobic core linked to a large and partially essential hydrophilic C terminus.
Schleyer, M., and E. P. Bakker.
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J Bacteriol. 1989;171(4):2219-21.
Specific cesium transport via the Escherichia coli Kup (TrkD) K+ uptake system.
Bossemeyer D, Schlosser A, Bakker EP.
(
2649491
)
|
ICN-UCLA Symp. Mol. Cell. Biol. 1980;19:137-159.
The origin of replication, oriC, of the Escherichia coli chromosome: genes near oriC and construction of oriC deletion mutations.
von Meyenburg, K., F. G. Hansen, E. Riise, H. E. N. Bergmans, M. Meijer, and W. Messer.
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| Sequences |
Amino acid
FASTA format
|
0001 MSTDNKQSLP AITLAAIGVV YGDIGTSPLY TLRECLSGQF GFGVERDAVF GFLSLIFWLL IFVVSIKYLT
0071 FVMRADNAGE GGILTLMSLA GRNTSARTTS MLVIMGLIGG SFFYGEVVIT PAISVMSAIE GLEIVAPQLD
0141 TWIVPLSIIV LTLLFMIQKH GTAMVGKLFA PIMLTWFLIL AGLGLRSIIA NPEVLHALNP MWAVHFFLEY
0211 KTVSFIALGA VVLSITGVEA LYADMGHFGK FPIRLAWFTV VLPSLTLNYF GQGALLLKNP EAIKNPFFLL
0281 APDWALIPLL IIAALATVIA SQAVISGVFS LTRQAVRLGY LSPMRIIHTS EMESGQIYIP FVNWMLYVAV
0351 VIVIVSFEHS SNLAAAYGIA VTGTMVLTSI LSTTVARQNW HWNKYFVALI LIAFLCVDIP LFTANLDKLL
0421 SGGWLPLSLG TVMFIVMTTW KSERFRLLRR MHEHGNSLEA MIASLEKSPP VRVPGTAVYM SRAINVIPFA
0491 LMHNLKHNKV LHERVILLTL RTEDAPYVHN VRRVQIEQLS PTFWRVVASY GWRETPNVEE VFHRCGLEGL
0561 SCRMMETSFF MSHESLILGK RPWYLRLRGK LYLLLQRNAL RAPDQFEIPP NRVIELGTQV EI
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ATTTAGGAGT ACGATTTTGC CGTTAATCGT
-070 GCATACTGTG CGCTTTTTTG TGGGCCAAGG GACTAAGCAC ACATTTCATA TTTCAACGAA AGACTAGTCT
0001 atgagcactg ataataagca atcattgccc gcgattaccc tcgcggcgat tggagttgtc tacggcgata
0071 ttggtaccag cccgttatat acacttcgtg aatgtttgtc cggccagttt ggttttggcg ttgaacgcga
0141 tgccgtgttt ggctttttat cgctgatctt ctggctgcta atctttgtgg tttccattaa atatctcacc
0211 ttcgtgatgc gggcagataa cgccggtgag ggggggatcc tgacgttgat gtcgcttgcc gggcgtaata
0281 cgtcggcgcg aaccacatca atgctggtga ttatggggct aatcggcggc agctttttct atggtgaagt
0351 cgtcataaca cccgctattt cggtgatgtc agccattgaa ggtctggaaa tcgtcgcccc gcagctggat
0421 acctggatag ttcccctctc aattatcgtt ctcactttat tatttatgat tcaaaaacat ggcacggcta
0491 tggtcggtaa gctgtttgcg ccgatcatgc tgacctggtt tttgattctg gcaggactgg ggttacgtag
0561 cattattgct aacccggaag tgctgcatgc gctgaatcca atgtgggcgg tgcatttctt ccttgaatac
0631 aaaacggttt cttttattgc attaggggca gtggtgttgt cgattacggg ggtcgaggcg ctgtatgctg
0701 atatggggca ctttggtaag ttccctattc gcctggcgtg gttcaccgtc gtattacctt ccttgaccct
0771 taattacttc ggtcagggag cgctgttgtt aaagaacccg gaagcgatta agaacccgtt cttcctgttg
0841 gcaccggact gggcgctgat cccgctgctg atcatcgccg cactggcgac ggtaattgcc tcgcaggcgg
0911 ttatctctgg cgtcttctca ttgacgcgtc aggcggtacg tctgggatat ttgtcgccga tgcgcattat
0981 tcacacctcc gaaatggagt cagggcaaat ctatattccg tttgtgaact ggatgctcta tgtcgcggtc
1051 gtgattgtga ttgtcagctt tgagcactcc agcaacctgg cggcggcgta cgggattgcg gtgaccggaa
1121 ccatggtgct gacgtctatt ctctcgacta ccgtggcacg tcagaactgg cactggaata agtattttgt
1191 tgcgctgatc ctgattgctt tcctttgtgt cgatattcca ttgttcaccg ctaacctcga taaactgctc
1261 tccggcggct ggttgccatt gagcctcggt actgtgatgt ttatcgtgat gaccacctgg aagagcgagc
1331 gtttccgctt gctgcggcgg atgcatgaac atggtaactc tctggaagcg atgattgctt cgctggagaa
1401 atcaccgcct gttcgcgtgc ccgggaccgc ggtgtatatg tcgcgtgcaa tcaacgtcat tccctttgcg
1471 ctgatgcata accttaaaca taacaaggta ttgcatgagc gggtgattct gttaactctg cgcaccgaag
1541 acgctccata tgtccataac gtccgtcggg tacagattga acaactgtcg cccactttct ggcgcgtggt
1611 ggcaagttat ggttggcgag aaacgccaaa cgtagaagaa gttttccacc gctgcggtct ggaaggatta
1681 agttgccgga tgatggaaac ctccttcttt atgtcgcatg agtcgttgat cctcggcaaa cgcccgtggt
1751 atttgcgtct gcgcggcaag ctgtacttgc tgctgcaacg taatgcgctg cgtgcaccag atcaatttga
1821 aatcccgcca aacagggtta tcgaactggg tactcaggtc gaaatctaaC GCCAGACGCC TCCTTTCTTC
1891 ATAAGGGGGC GTTTTTGTTT TCATGGTTAA TCACCATGTA AAACGTTTCG AGGTTGATCA CATTTCCGTA
1961 ACGTCACGA
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