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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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J Biol Chem. 1996;271(1):32-9.
Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.
Mengin-Lecreulx D, van Heijenoort J.
(
8550580
)
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Deletion
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OCL29,30-6 (AK4-11 / BK5-11)
(D)
,
OCL29-6
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
glmM
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Related strains
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Strains Search
|
Search strains by gene name:
glmM
Search strains by all related name:
glmM b3176 ECK3165 f445 JW3143 mrsA yhbF
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General information (Go to Linear View: )
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Gene Name
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glmM
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Alternative name
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b3176,ECK3165,f445,JW3143,mrsA,yhbF
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Location, Length
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3,320,755 - 3,322,092
(
-
)
;
71.57
min
;
1338
(bp) ,
445
(aa)
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Product
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phosphoglucosamine mutase
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Operon Name
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folP-glmM
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Note
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GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0042280 - cell surface antigen activity, host-interacting; GO_process: GO:0009243 - O antigen biosynthetic process; GO_process: GO:0009246 - enterobacterial common antigen biosynthetic process; GO_process: GO:0006006 - glucose metabolic process; GO_process: GO:0009252 - peptidoglycan biosynthetic process
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Function
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putative enzyme; Central intermediary metabolism: Miscellaneous glucose metabolism
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Gene Ontology
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GO:0000287
;
magnesium ion binding ( glmM )
GO:0005515
;
protein binding ( glmM )
GO:0005975
;
carbohydrate metabolic process ( glmM )
GO:0008966
;
phosphoglucosamine mutase activity ( glmM )
GO:0016853
;
isomerase activity ( glmM )
GO:0016868
;
intramolecular transferase activity, phosphotransferases ( glmM )
GO:0046872
;
metal ion binding ( glmM )
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PID
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1789566
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EC number
(KEGG Pathway)
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5.4.2.10
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
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GLMM_ECOLI
(
P31120
)
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- Protein name
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Phosphoglucosamine mutase
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- Synonyms
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EC 5.4.2.10
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- Gene name
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Name=glmM; Synonyms=mrsA; OrderedLocusNames=b3176;
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- Comments
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CATALYTIC ACTIVITY:Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
COFACTOR:Binds 1 magnesium ion per subunit (By similarity).
SIMILARITY:Belongs to the phosphohexose mutase family.
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Entry name(Acc.no)
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Q8FD84
(
Q8FD84
)
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- Protein name
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Protein mrsA.
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- Synonyms
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- Gene name
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Name=mrsA; OrderedLocusNames=c3932;
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- Comments
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SIMILARITY:Contains 1 histidine kinase domain.
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Entry name(Acc.no)
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Q8X9L2
(
Q8X9L2
)
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- Protein name
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Similar to phosphoglucomutases and phosphomannomutases.
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- Synonyms
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- Gene name
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Name=mrsA; OrderedLocusNames=z4538;
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- Comments
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SUBCELLULAR LOCATION:Integral membrane protein (By similarity).
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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glmM
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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Chain A, Crystal Structure Of Pyrococcus Horikoshii PhosphomannomutasePHOSPHOGLUCOMUTASE COMPLEXED WITH MG2+
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Phosphoglucosamine mutase
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PSI-BLAST
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Phosphoglucosamine mutase
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nr
(database updated :
2007.02.20
)
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BLAST
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phosphoglucosamine mutase [Escherichia coli K12]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
PGM_PMM
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MMBR References
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J Biol Chem. 1996;271:32-39
Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli.
Mengin-Lecreulx, D., and J. van Heijenoort.
|
GenBank submission U01376. 1996
Identification and physical analysis of new genes in the argG region (69 min) of Escherichia coli chromosome.
Wang, R. F., and S. R. Kushner.
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| Sequences |
Amino acid
FASTA format
|
0001 MSNRKYFGTD GIRGRVGDAP ITPDFVLKLG WAAGKVLARH GSRKIIIGKD TRISGYMLES ALEAGLAAAG
0071 LSALFTGPMP TPAVAYLTRT FRAEAGIVIS ASHNPFYDNG IKFFSIDGTK LPDAVEEAIE AEMEKEISCV
0141 DSAELGKASR IVDAAGRYIE FCKATFPNEL SLSELKIVVD CANGATYHIA PNVLRELGAN VIAIGCEPNG
0211 VNINAEVGAT DVRALQARVL AEKADLGIAF DGDGDRVIMV DHEGNKVDGD QIMYIIAREG LRQGQLRGGA
0281 VGTLMSNMGL ELALKQLGIP FARAKVGDRY VLEKMQEKGW RIGAENSGHV ILLDKTTTGD GIVAGLQVLA
0351 AMARNHMSLH DLCSGMKMFP QILVNVRYTA GSGDPLEHES VKAVTAEVEA ALGNRGRVLL RKSGTEPLIR
0421 VMVEGEDEAQ VTEFAHRIAD AVKAV
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 atgcaaggcg cgcacatcat tcgtgttcat
-070 gacgtcaaag aaaccgtaga agcgatgcgg gtggtggaag ccactctgtc tgcaaaggaa aacaaacgct
0001 atgagtaatc gtaaatattt cggtaccgat gggattcgtg gtcgtgtagg ggatgcgccg atcacacctg
0071 attttgtgct taagctgggt tgggccgcgg gtaaagtgct ggcgcgccac ggctcccgta agattattat
0141 tggtaaagac acgcgtattt ctggctatat gctggagtca gcactggaag cgggtctggc ggcagcgggc
0211 ctttccgcac tcttcactgg cccgatgcca acaccggccg tggcttatct gacgcgtacc ttccgcgcag
0281 aggccggaat tgtgatatct gcatcgcata acccgttcta cgataatggc attaaattct tctctatcga
0351 cggcaccaaa ctgccggatg cggtagaaga ggccatcgaa gcggaaatgg aaaaggagat cagctgcgtt
0421 gattcggcag aactgggtaa agccagccgt atcgttgatg ccgcgggtcg ctatatcgag ttttgcaaag
0491 ccacgttccc gaacgaactt agcctcagtg aactgaagat tgtggtggat tgtgcaaacg gtgcgactta
0561 tcacatcgcg ccgaacgtgc tgcgcgaact gggggcgaac gttatcgcta tcggttgtga gccaaacggt
0631 gtaaacatca atgccgaagt gggggctacc gacgttcgcg cgctccaggc tcgtgtgctg gctgaaaaag
0701 cggatctcgg tattgccttc gacggcgatg gcgatcgcgt gattatggtt gaccatgaag gcaataaagt
0771 cgatggcgat cagatcatgt atatcatcgc gcgtgaaggt cttcgtcagg gccagctgcg tggtggcgct
0841 gtgggtacat tgatgagcaa catggggctt gaactggcgc tgaaacagtt aggaattcca tttgcgcgcg
0911 cgaaagtggg tgaccgctac gtactggaaa aaatgcagga gaaaggctgg cgtatcggtg cagagaattc
0981 cggtcatgtg atcctgctgg ataaaactac taccggtgac ggcatcgttg ctggcttgca ggtgctggcg
1051 gcgatggcac gtaaccatat gagcctgcac gacctttgca gcggcatgaa aatgttcccg cagattctgg
1121 ttaacgtacg ttacaccgca ggtagcggcg atccacttga gcatgagtca gttaaagccg tgaccgcaga
1191 ggttgaagct gcgctgggca accgtggacg cgtgttgctg cgtaaatccg gcaccgaacc gttaattcgc
1261 gtgatggtgg aaggcgaaga cgaagcgcag gtgactgaat ttgcacaccg catcgccgat gcagtaaaag
1331 ccgtttaaag cgttagataa ctggctaaaa aggcggcgat tgtcgccttt tttctcagcg aacacatcgg
1401 ttttgctgtt tttttccgca gttgatacaa tgcgataa
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