|
PEC Original Annotations
|
|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
|
|
Deletion
|
OCL52,53-1
(D)
,
OCL52-2
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
tyrA
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
tyrA
Search strains by all related name:
tyrA b2600 ECK2597 JW2581
|
General information (Go to Linear View: )
|
|
Gene Name
|
tyrA
|
|
Alternative name
|
b2600,ECK2597,JW2581
|
|
Location, Length
|
2,736,970 - 2,738,091
(
-
)
;
58.99
min
;
1122
(bp) ,
373
(aa)
|
|
Product
|
fused chorismate mutase T/prephenate dehydrogenase
|
|
Operon Name
|
aroF-tyrA
|
|
Note
|
chorismate mutase-T and prephenate dehydrogenase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009094 - L-phenylalanine biosynthetic process; GO_process: GO:0006571 - tyrosine biosynthetic process
|
|
Function
|
enzyme; Amino acid biosynthesis: Tyrosine
|
|
Gene Ontology
|
GO:0003824
;
catalytic activity ( tyrA )
GO:0004106
;
chorismate mutase activity ( tyrA )
GO:0004665
;
prephenate dehydrogenase (NADP+) activity ( tyrA )
GO:0005488
;
binding ( tyrA )
GO:0005737
;
cytoplasm ( tyrA )
GO:0006571
;
tyrosine biosynthetic process ( tyrA )
GO:0008152
;
metabolic process ( tyrA )
GO:0008652
;
amino acid biosynthetic process ( tyrA )
GO:0008977
;
prephenate dehydrogenase activity ( tyrA )
GO:0009073
;
aromatic amino acid family biosynthetic process ( tyrA )
GO:0016491
;
oxidoreductase activity ( tyrA )
GO:0016853
;
isomerase activity ( tyrA )
|
|
PID
|
1788952
|
EC number
(KEGG Pathway)
|
1.3.1.12
5.4.99.5
|
|
SWISS-PROT
(
Show simple
)
|
Entry name(Acc.no)
|
TYRA_ECOLI
(
P07023
;
P78205; P78206
)
|
|
- Protein name
|
T-protein
|
|
- Synonyms
|
|
|
- Gene name
|
Name=tyrA; OrderedLocusNames=b2600;
|
|
- Comments
|
CATALYTIC ACTIVITY:Chorismate = prephenate.
CATALYTIC ACTIVITY:Prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH.
PATHWAY:Tyrosine biosynthesis.
SUBCELLULAR LOCATION:Cytoplasmic.
|
|
Entry name(Acc.no)
|
Q8FEZ5
(
Q8FEZ5
)
|
|
- Protein name
|
T-protein.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=tyrA; OrderedLocusNames=c3121;
|
|
- Comments
|
FUNCTION:Stimulates, jointly with dnaJ, the ATPase activity of dnaK. Helps to release ADP from dnaK thus allowing dnaK to recycle more efficiently (By similarity).
SIMILARITY:Belongs to the grpE family.
|
|
Entry name(Acc.no)
|
Q8X9E3
(
Q8X9E3
)
|
|
- Protein name
|
Chorismate mutase-T and prephenate dehydrogenase.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=tyrA; OrderedLocusNames=z3892;
|
|
- Comments
|
SIMILARITY:Belongs to the ompA family.
|
|
MMBR References
|
J Mol Biol. 1984;180(4):1023-51.
Nucleotide sequence and transcription of the phenylalanine and tyrosine operons of Escherichia coli K12.
Hudson GS, Davidson BE.
(
6396419
)
|
J Bacteriol. 1971;107(1):8-15.
Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants.
Mattern IE, Pittard J.
(
4397929
)
|
| Sequences |
Amino acid
FASTA format
|
0001 MVAELTALRD QIDEVDKALL NLLAKRLELV AEVGEVKSRF GLPIYVPERE ASMLASRRAE AEALGVPPDL
0071 IEDVLRRVMR ESYSSENDKG FKTLCPSLRP VVIVGGGGQM GRLFEKMLTL SGYQVRILEQ HDWDRAADIV
0141 ADAGMVIVSV PIHVTEQVIG KLPPLPKDCI LVDLASVKNG PLQAMLVAHD GPVLGLHPMF GPDSGSLAKQ
0211 VVVWCDGRKP EAYQWFLEQI QVWGARLHRI SAVEHDQNMA FIQALRHFAT FAYGLHLAEE NVQLEQLLAL
0281 SSPIYRLELA MVGRLFAQDP QLYADIIMSS ERNLALIKRY YKRFGEAIEL LEQGDKQAFI DSFRKVEHWF
0351 GDYAQRFQSE SRVLLRQAND NRQ
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gatgcctgca ttagctggga aatgaccgat
-070 gccttgctgc gtgaaattca tcaggatctg aacgggcagc tgacggctcg cgtggcttaa gaggtttatt
0001 atggttgctg aattgaccgc attacgcgat caaattgatg aagtcgataa agcgctgctg aatttattag
0071 cgaagcgtct ggaactggtt gctgaagtgg gcgaggtgaa aagccgcttt ggactgccta tttatgttcc
0141 ggagcgcgag gcatctatgt tggcctcgcg tcgtgcagag gcggaagctc tgggtgtacc gccagatctg
0211 attgaggatg ttttgcgtcg ggtgatgcgt gaatcttact ccagtgaaaa cgacaaagga tttaaaacac
0281 tttgtccgtc actgcgtccg gtggttatcg tcggcggtgg cggtcagatg ggacgcctgt tcgagaagat
0351 gctgaccctc tcgggttatc aggtgcggat tctggagcaa catgactggg atcgagcggc tgatattgtt
0421 gccgatgccg gaatggtgat tgttagtgtg ccaatccacg ttactgagca agttattggc aaattaccgc
0491 ctttaccgaa agattgtatt ctggtcgatc tggcatcagt gaaaaatggg ccattacagg ccatgctggt
0561 ggcgcatgat ggtccggtgc tggggctaca cccgatgttc ggtccggaca gcggtagcct ggcaaagcaa
0631 gttgtggtct ggtgtgatgg acgtaaaccg gaagcatacc aatggtttct ggagcaaatt caggtctggg
0701 gcgctcggct gcatcgtatt agcgccgtcg agcacgatca gaatatggcg tttattcagg cactgcgcca
0771 ctttgctact tttgcttacg ggctgcacct ggcagaagaa aatgttcagc ttgagcaact tctggcgctc
0841 tcttcgccga tttaccgcct tgagctggcg atggtcgggc gactgtttgc tcaggatccg cagctttatg
0911 ccgacatcat tatgtcgtca gagcgtaatc tggcgttaat caaacgttac tataagcgtt tcggcgaggc
0981 gattgagttg ctggagcagg gcgataagca ggcgtttatt gacagtttcc gcaaggtgga gcactggttc
1051 ggcgattacg cacagcgttt tcagagtgaa agccgcgtgt tattgcgtca ggcgaatgac aatcgccagt
1121 aataatccag tgccggatga ttcacatcat ccggcacctt ttcatcaggt tggatcaaca ggcactacgt
1191 tctcacttgg gtaacagccc aataccttca tt
|
