MG1655
W3110
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Gene Report : cysW
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL60-21 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  cysW
Related strains
     Strains Search Search strains by gene name:  cysW   Search strains by all related name:  cysW b2423 ECK2418 f149 JW2416

General information  (Go to Linear View:)
 Gene Name cysW  
 Alternative name b2423,ECK2418,f149,JW2416  
 Location, Length 2,538,826 - 2,539,701 (  -  ) ;   54.72 min ; 876 (bp) ,   291 (aa) Go to Linear View
 Product sulfate/thiosulfate ABC transporter subunit  
 Operon Name cysPUWAM  
 Note sulfate transport system permease W protein; membrane component of ABC superfamily; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0006790 - sulfur metabolic process  
 Function transport; Transport of small molecules: Anions  
 Gene Ontology GO:0005215 ; transporter activity ( cysW )
GO:0005886 ; plasma membrane ( cysW )
GO:0006810 ; transport ( cysW )
GO:0008272 ; sulfate transport ( cysW )
GO:0009276 ; 1-2nm peptidoglycan-based cell wall ( cysW )
GO:0015116 ; sulfate transmembrane transporter activity ( cysW )
GO:0015563 ; uptake transmembrane transporter activity ( cysW )
GO:0016020 ; membrane ( cysW )
GO:0016021 ; integral to membrane ( cysW )
 PID 87082099  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) CYSW_ECOLI ( P16702 ; P76534 )
    -  Protein name Sulfate transport system permease protein cysW.  
    -  Synonyms  
    -  Gene name Name=cysW; OrderedLocusNames=b2423, c2957;  
    -  Comments
  • FUNCTION:Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
  • SUBUNIT:The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW) and a solute-binding protein (cysP) (Probable).
  • SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane (Potential).
  • SIMILARITY:Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.  
    •   botton Entry name(Acc.no) Q8XBJ7 ( Q8XBJ7 )
        -  Protein name Sulfate/thiosulfate transport system permease W protein.  
        -  Synonyms  
        -  Gene name Name=cysW; OrderedLocusNames=z3688;  
        -  Comments
  • FUNCTION:Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
  • SUBCELLULAR LOCATION:Integral membrane protein (By similarity).
  • SIMILARITY:Belongs to the binding-protein-dependent transport system permease family.  

    •  Linear View (Whole Mode)
    View Location
       2530.0  –  2555.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP cysW (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
            PSI-BLAST  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Sulfate transport system permease protein cysW  
             PSI-BLAST Sulfate transport system permease protein cysW
        nr     (database updated : 2007.02.20 )
             BLAST hypothetical protein c2957 [Escherichia coli CFT073]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    BPD_TRANSP_INN_MEMBR     

    Other Cross-Reference
        COG COG4208P 
        EcoCyc cysW 

    MMBR References
    J Bacteriol. 1990;172(6):3351-7.
    Sulfate and thiosulfate transport in Escherichia coli K-12: nucleotide sequence and expression of the cysTWAM gene cluster.
    Sirko A, Hryniewicz M, Hulanicka D, Bock A. ( 2188958 )

    Sequences
    Amino acid
    FASTA format 
    0001 MAEVTQLKRY DARPINWGKW FLIGIGMLVS AFILLVPMIY IFVQAFSKGL MPVLQNLADP DMLHAIWLTV 
0071 MIALIAVPVN LVFGILLAWL VTRFNFPGRQ LLLTLLDIPF AVSPVVAGLV YLLFYGSNGP LGGWLDEHNL 
0141 QIMFSWPGMV LVTIFVTCPF VVRELVPVML SQGSQEDEAA ILLGASGWQM FRRVTLPNIR WALLYGVVLT 
0211 NARAIGEFGA VSVVSGSIRG ETLSLPLQIE LLEQDYNTVG SFTAAALLTL MAIITLFLKS MLQWRLENQE 
0281 KRAQQEEHHE H
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             cgagcgcgat tgcttcggtg atcctcgcgg 
-070 catctctgct gctgctgttc tcaattaaca ctctgcaaag tcgctttggt cggcgtgtgg taggtcatta 
0001 atggcggaag ttacccaatt gaagcgttat gacgcgcgcc cgattaactg gggcaaatgg tttctgattg 
0071 gcatcgggat gctggtttcg gcgttcatcc tgctggtgcc gatgatttac atcttcgtgc aggcattcag 
0141 caaggggctg atgccggttt tacagaatct ggccgatccg gacatgctgc acgccatctg gctgacggtg 
0211 atgatcgcgc tgattgccgt accggtaaac ctggtgttcg gcattctgct ggcctggctg gtgacgcgct 
0281 ttaacttccc tggacgccag ttactgctga cgctactgga cattccgttt gccgtatcgc cggtggttgc 
0351 cggtctggtg tatttgctgt tctacggctc taacggcccg ctcggcggtt ggctcgacga gcataacctg 
0421 caaattatgt tctcctggcc gggaatggtg ctggtcacca tcttcgtgac gtgtccgttt gtggtgcgcg 
0491 aactggtgcc ggtgatgtta agccagggca gccaggaaga cgaagcggcg attttgcttg gcgcgtccgg 
0561 ctggcagatg ttccgtcgcg tcacattacc gaacatccgc tgggcgctgc tttatggcgt ggtgttgacc 
0631 aacgcccgcg caattggcga gtttggcgcg gtgtcggtgg tttccggctc gattcgcggc gaaaccctgt 
0701 cgctgccgtt acagattgaa ttgctggagc aggactacaa caccgtcggc tcctttaccg ctgcggcgct 
0771 gttaacgctg atggcgatta tcaccctgtt tttaaaaagt atgttgcagt ggcgcctgga gaatcaggaa 
0841 aaacgcgcac agcaggagga acatcatgag cattgagatt gccaatatta agaagtcgtt tggtcgcacc 
0911 caggtgctga acgatatctc actggatatt ccttcaggtc agatggtcgc gttgctgggg ccgtcc