MG1655
W3110
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Gene Report : hisQ
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL64 (D)  ,  OCL64-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  hisQ
Related strains
     Strains Search Search strains by gene name:  hisQ   Search strains by all related name:  hisQ b2308 ECK2302 JW2305

General information  (Go to Linear View:)
 Gene Name hisQ  
 Alternative name b2308,ECK2302,JW2305  
 Location, Length 2,423,252 - 2,423,938 (  -  ) ;   52.23 min ; 687 (bp) ,   228 (aa) Go to Linear View
 Product histidine/lysine/arginine/ornithine transporter permease subunit  
 Operon Name argT-hisJQMP  
 Note histidine transport system permease protein; membrane component of ABC superfamily; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0009089 - lysine biosynthetic process via diaminopimelate; GO_process: GO:0006526 - arginine biosynthetic process  
 Function transport; Transport of small molecules: Amino acids, amines  
 Gene Ontology GO:0005215; transporter activity ( hisQ )
GO:0005886; plasma membrane ( hisQ )
GO:0006810; transport ( hisQ )
GO:0006865; amino acid transport ( hisQ )
GO:0009276; 1-2nm peptidoglycan-based cell wall ( hisQ )
GO:0016020; membrane ( hisQ )
GO:0016021; integral to membrane ( hisQ )
 PID 1788646  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) HISQ_ECOLI ( P52094 ; P77635 )
    -  Protein name Histidine transport system permease protein hisQ.  
    -  Synonyms  
    -  Gene name Name=hisQ; OrderedLocusNames=b2308;  
    -  Comments
  • FUNCTION:Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane.
  • SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
  • SIMILARITY:Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.  
  •   botton Entry name(Acc.no) Q8FFI3 ( Q8FFI3 )
        -  Protein name Histidine transport system permease protein hisQ.  
        -  Synonyms  
        -  Gene name Name=hisQ; OrderedLocusNames=c2850;  
        -  Comments
  • FUNCTION:Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
  • SUBCELLULAR LOCATION:Integral membrane protein (By similarity).
  • SIMILARITY:Belongs to the binding-protein-dependent transport system permease family.  
  •   botton Entry name(Acc.no) Q8XCS7 ( Q8XCS7 )
        -  Protein name Histidine transport system permease protein.  
        -  Synonyms  
        -  Gene name Name=hisQ; OrderedLocusNames=z3570;  
        -  Comments
  • FUNCTION:Part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane (By similarity).
  • SUBCELLULAR LOCATION:Integral membrane protein (By similarity).
  • SIMILARITY:Belongs to the binding-protein-dependent transport system permease family.  

  •  Linear View (Whole Mode)
    View Location
       2410.0  –  2435.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP hisQ (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
            PSI-BLAST  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Histidine transport system permease protein hisQ  
             PSI-BLAST Glutamate transport system permease protein gluD
        nr     (database updated : 2007.02.20 )
             BLAST histidine/lysine/arginine/ornithine transporter subunit [Escherichia coli K12]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    BPD_TRANSP_INN_MEMBR     

    Other Cross-Reference
        COG COG4215E 
        EcoCyc hisQ 

    MMBR References
    J. Supramol. Struct. (Suppl.) 1980;13:117-130.
    Cloning of the histidine transport genes from Salmonella typhimurium and characterization of an analogous transport system in Escherichia coli.
    Ardeshir, F., and G. F.-L. Ames.

    Sequences
    Amino acid
    FASTA format
    0001 MLYGFSGVIL QGALVTLELA ISSVVLAVII GLIGAGGKLS QNRLSGLIFE GYTTLIRGVP DLVLMLLIFY 
    0071 GLQIALNTVT EAMGVGQIDI DPMVAGIITL GFIYGAYFTE TFRGAFMAVP KGHIEAATAF GFTRGQVFRR 
    0141 IMFPSMMRYA LPGIGNNWQV ILKSTALVSL LGLEDVVKAT QLAGKSTWEP FYFAIVCGVI YLVFTTVSNG 
    0211 VLLFLERRYS VGVKRADL
    
    
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp
    -100                                             atggtggcta atcgccatcg gtgaaagaaa 
    -070 gcccgctccc ttcgggtaac cggagggaga caagaggcgg taattcacca cacacgacag gacaggcagc 
    0001 atgttgtatg ggttttcagg tgttatttta cagggtgcgc tcgtcacgct ggagctggct atcagctctg 
    0071 tagtgctcgc tgtaatcatc ggtttaattg gcgctggcgg taagctctcg caaaatcggc tttcggggct 
    0141 gattttcgaa gggtacacca cgctgattcg tggcgtgccg gacttagtgt tgatgctgct gattttctac 
    0211 ggtttgcaga ttgcgctaaa cacggtgacg gaggcgatgg gcgtcgggca gattgatatc gatccgatgg 
    0281 tcgctggtat tatcactctc ggttttatct acggtgctta ttttaccgaa acgttccgtg gtgcttttat 
    0351 ggcagtgccg aaaggacata tagaggcggc gacggcgttc ggttttactc gtgggcaagt gtttcggcgg 
    0421 atcatgtttc cgtcgatgat gcgttacgcc ctgccaggca ttggcaacaa ctggcaggtg atcctcaaat 
    0491 ctaccgcact ggtttcgtta ctcggcctgg aagatgtggt caaagccacc caactggcag gcaaaagtac 
    0561 ctgggaaccg ttctatttcg ccatcgtctg tggcgtgatt tacctggttt tcaccactgt ttccaatggt 
    0631 gtgctgctgt tccttgagcg ccgctactcc gtgggtgtga agagggctga cctgtgatcg aaatcttaca 
    0701 tgaatactgg aaaccgctgc tgtggaccga cggttatcgc tttactggtg tggcgatcac tctgtggctg 
    0771 cttattttgt cggtagt