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PEC Original Annotations
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|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
Mol Gen Genet. 1996;252(3):332-41.
The role of the genes nrf EFG and ccmFH in cytochrome c biosynthesis in Escherichia coli.
Grovc J, Busby S, Cole J.
(
8842153
)
|
|
|
Deletion
|
14
(LD)
,
OCL70,72-3 (LD 14B_CRS)
(D)
,
OCL70,72-4 (LD 14C_P/O)
(D)
,
OCL72
(D)
|
|
Related gene (W3110 PEC)
|
|
Gene Search
|
Search MG1655 PEC by gene name:
ccmH
|
|
Related strains
|
|
Strains Search
|
Search strains by gene name:
ccmH
Search strains by all related name:
ccmH b2194 ECK2186 JW2182 yejP
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General information (Go to Linear View: )
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Gene Name
|
ccmH
|
|
Alternative name
|
b2194,ECK2186,JW2182,yejP
|
|
Location, Length
|
2,289,380 - 2,290,432
(
-
)
;
49.34
min
;
1053
(bp) ,
350
(aa)
|
|
Product
|
heme lyase, CcmH subunit
|
|
Operon Name
|
napFDAGHBC-ccmABCDEFGH
|
|
Note
|
possible subunit of heme lyase; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane; GO_process: GO:0017004 - cytochrome complex assembly; GO_process: GO:0006457 - protein folding
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Function
|
putative enzyme; Energy metabolism, carbon: Electron transport
|
|
Gene Ontology
|
GO:0005488
;
binding ( ccmH )
GO:0005506
;
iron ion binding ( ccmH )
GO:0005886
;
plasma membrane ( ccmH )
GO:0016020
;
membrane ( ccmH )
GO:0016021
;
integral to membrane ( ccmH )
GO:0017004
;
cytochrome complex assembly ( ccmH )
GO:0042597
;
periplasmic space ( ccmH )
GO:0046872
;
metal ion binding ( ccmH )
|
|
PID
|
1788522
|
EC number
(KEGG Pathway)
|
|
|
SWISS-PROT
(
Show simple
)
|
Entry name(Acc.no)
|
CCMH_ECOLI
(
P33925
)
|
|
- Protein name
|
Cytochrome c-type biogenesis protein ccmH precursor.
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- Synonyms
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- Gene name
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Name=ccmH; OrderedLocusNames=b2194, SF2278, S2408;
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- Comments
|
FUNCTION:May be required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
SUBCELLULAR LOCATION:Periplasmic (Probable).
SIMILARITY:Belongs to the ccmH/cycL/ccl2/nrfF family.
SIMILARITY:Contains 2 TPR repeats.
|
|
Entry name(Acc.no)
|
Q8CVW6
(
Q8CVW6
)
|
|
- Protein name
|
Cytochrome c-type biogenesis protein ccmH.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=ccmH; OrderedLocusNames=c2731;
|
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- Comments
|
SUBCELLULAR LOCATION:Periplasmic (By similarity).
SIMILARITY:Belongs to the periplasmic pilus chaperone family.
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Entry name(Acc.no)
|
Q8XE65
(
Q8XE65
)
|
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- Protein name
|
Possible subunit of heme lyase.
|
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- Synonyms
|
|
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- Gene name
|
Name=ccmH; OrderedLocusNames=z3451;
|
|
- Comments
|
SIMILARITY:Belongs to the ABC transporter family.
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MMBR References
|
Mol Gen Genet. 1996;252(3):332-41.
The role of the genes nrf EFG and ccmFH in cytochrome c biosynthesis in Escherichia coli.
Grovc J, Busby S, Cole J.
(
8842153
)
|
Mol Microbiol. 1996;19(3):467-81.
Escherichia coli K-12 genes essential for the synthesis of c-type cytochromes and a third nitrate reductase located in the periplasm.
Grove J, Tanapongpipat S, Thomas G, Griffiths L, Crooke H, Cole J.
(
8830238
)
|
J Bacteriol. 1995;177:4321-4326
Escherichia coli genes required for cytochrome c maturation.
Thony-Meyer, L., F. Fischer, P. Kunzler, D. Ritz, and H. Hennecke.
|
J Bacteriol. 1991;173(19):6139-46.
Anaerobically expressed Escherichia coli genes identified by operon fusion techniques.
Choe M, Reznikoff WS.
(
1917846
)
|
J Bacteriol. 1993;175:1165-1172
Identification of the regulatory sequence of anaerobically expressed locus aeg-46.5.
Choe, M., and W. S. Reznikoff.
|
| Sequences |
Amino acid
FASTA format
|
0001 MRFLLGVLML MISGSALATI DVLQFKDEAQ EQQFRQLTEE LRCPKCQNNS IADSNSMIAT DLRQKVYELM
0071 QEGKSKKEIV DYMVARYGNF VTYDPPLTPL TVLLWVLPVV AIGIGGWVIY ARSRRRVRVV PEAFPEQSVP
0141 EGKRAGYVVY LPGIVVALIV AGVSYYQTGN YQQVKIWQQA TAQAPALLDR ALDPKADPLN EEEMSRLALG
0211 MRTQLQKNPG DIEGWIMLGR VGMALGNASI ATDAYATAYR LDPKNSDAAL GYAEALTRSS DPNDNRLGGE
0281 LLRQLVRTDH SNIRVLSMYA FNAFEQQRFG EAVAAWEMML KLLPANDTRR AVIERSIAQA MQHLSPQESK
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 acggcatcat tcgctatcgc catgcgggcg
-070 atctgaatcc tcgcgtctgg gaagaagaga tcaagccgct gtgggagaaa tacagtaagg aggccgcaca
0001 atgaggtttt tattgggcgt gctgatgctg atgatctccg gctcagcgct ggcgaccatc gatgtgttgc
0071 agtttaaaga tgaagcacag gaacaacagt tccgtcagct cactgaagaa ctgcgctgcc cgaaatgcca
0141 gaacaacagc attgccgatt ccaactcgat gattgccacc gacctgcgtc agaaagtgta tgaactgatg
0211 caggaaggta aaagtaaaaa agagattgtc gattatatgg tggcgcgtta cggcaacttc gtcacttacg
0281 atccgccgtt aacgccgctg accgtgctgc tgtgggtgct gccagtagtg gctattggca ttggcggttg
0351 ggtcatatac gcccgctcgc ggcgtcgggt acgcgtggtg ccggaagcgt ttcctgaaca aagcgtgccg
0421 gaaggtaagc gtgccggata tgttgtttat ctgccgggta ttgtggtggc gttaattgtg gctggcgtca
0491 gctactacca gactggcaat tatcagcagg tgaaaatctg gcagcaggcc acggcacagg ctccggcgtt
0561 gctggacagg gcgctggatc cgaaagccga tccgctcaac gaagaagaga tgtcgcgtct tgcgctgggg
0631 atgcgtactc aactgcaaaa aaatccggga gatatagaag gctggattat gttgggccgc gttggcatgg
0701 cgctgggtaa cgccagtatc gccaccgatg catacgccac tgcgtatcgc ctcgatccga aaaacagtga
0771 tgctgcactg ggatacgctg aagcgttgac tcgttcatct gatcccaacg acaaccgcct cggcggtgaa
0841 ctgctacgtc agctggtgag aacggaccat agcaatatcc gtgtgctaag catgtatgcg tttaatgcct
0911 ttgagcagca gcgatttggc gaagccgttg ccgcgtggga gatgatgttg aaactcttac ctgccaacga
0981 tactcgccgt gcggtgattg aacgtagtat cgcgcaggcg atgcaacatt tgtcgccgca ggagagtaaa
1051 taaaaagagg cccgatggtg atgccatcgg gctagactgt tgacaaagtg cgcttagttt atgccggatg
1121 cggcgtgaac gccttatccg gcctacaaaa ttg
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