MG1655
W3110
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Gene Report : nac
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
     Deletion OCL75 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  nac
Related strains
     Strains Search Search strains by gene name:  nac   Search strains by all related name:  nac b1988 ECK1983 f310 JW1967

General information  (Go to Linear View:)
 Gene Name nac  
 Alternative name b1988,ECK1983,f310,JW1967  
 Location, Length 2,059,040 - 2,059,957 (  -  ) ;   44.38 min ; 918 (bp) ,   305 (aa) Go to Linear View
 Product DNA-binding transcriptional dual regulator of nitrogen assimilation  
 Operon Name nac  
 Note nitrogen assimilation control protein; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016564 - transcription repressor activity; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0006807 - nitrogen compound metabolic process; GO_process: GO:0006350 - transcription  
 Function regulator; Central intermediary metabolism  
 Gene Ontology GO:0003677 ; DNA binding ( nac )
GO:0003700 ; transcription factor activity ( nac )
GO:0005515 ; protein binding ( nac )
GO:0006350 ; transcription ( nac )
GO:0006355 ; regulation of transcription, DNA-dependent ( nac )
GO:0042128 ; nitrate assimilation ( nac )
 PID 1788297  
 EC number
  (KEGG Pathway)   		 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) NAC_ECOLI ( Q47005 )
    -  Protein name Nitrogen assimilation regulatory protein nac  
    -  Synonyms Nitrogen assimilation control protein  
    -  Gene name Name=nac; OrderedLocusNames=b1988;  
    -  Comments
  • FUNCTION:Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity).
  • SIMILARITY:Contains 1 HTH lysR-type DNA-binding domain.  
    •   botton Entry name(Acc.no) Q8CXY9 ( Q8CXY9 )
        -  Protein name Nitrogen assimilation Regulatory protein nac.  
        -  Synonyms  
        -  Gene name Name=nac; OrderedLocusNames=c2446;  
        -  Comments
  • SIMILARITY:Contains 1 HTH lysR-type DNA-binding domain.  
    •   botton Entry name(Acc.no) Q8X8V2 ( Q8X8V2 )
        -  Protein name Nitrogen assimilation control protein.  
        -  Synonyms  
        -  Gene name Name=nac; OrderedLocusNames=z3147;  
        -  Comments
  • SIMILARITY:Contains 1 HTH lysR-type DNA-binding domain.  

    •  Linear View (Whole Mode)
    View Location
       2050.0  –  2075.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP nac (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain B, Dntr From Burkholderia Sp. Strain Dnt  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Nitrogen assimilation regulatory protein nac  
             PSI-BLAST Putative HTH-type transcriptional regulator ywbI
        nr     (database updated : 2007.02.20 )
             BLAST DNA-binding transcriptional dual regulator of nitrogen assimilation [Escherichia coli K12]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE GLYCOSAMINOGLYCAN    CAMP_PHOSPHO_SITE    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    LEUCINE_ZIPPER    HTH_LYSR_FAMILY     

    Other Cross-Reference
        COG COG0583K 
        EcoCyc nac 

    MMBR References
    J Bacteriol. 1998;180:1166-1173
    The nac (nitrogen assimilation control) gene from Escherichia coli.
    Muse, W. B., and R. A. Bender.

    Sequences
    Amino acid
    FASTA format 
    0001 MNFRRLKYFV KIVDIGSLTQ AAEVLHIAQP ALSQQVATLE GELNQQLLIR TKRGVTPTDA GKILYTHARA 
0071 ILRQCEQAQL AVHNVGQALS GQVSIGFAPG TAASSITMPL LQAVRAEFPE IVIYLHENSG AVLNEKLINH 
0141 QLDMAVIYEH SPVAGVSSQA LLKEDLFLVG TQDCPGQSVD VNAIAQMNLF LPSDYSAIRL RVDEAFSLRR 
0211 LTAKVIGEIE SIATLTAAIA SGMGVAVLPE SAARSLCGAV NGWMSRITTP SMSLSLSLNL PARANLSPQA 
0281 QAVKELLMSV ISSPVMEKRQ WQLVS
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             tagcttgtac atcaacacca aaataaaact 
-070 ggcaagcatc ttgcaatctg gttgtaagta atggcggcac ttgggccgat tcttaaaaac cggaggcaac 
0001 atgaacttca gacgcctgaa atacttcgta aaaattgtag atattggtag cctgacccag gctgctgaag 
0071 tattgcatat cgcacaacca gcgctcagcc agcaggttgc cacactggaa ggtgagttaa atcaacaact 
0141 tttgatccgt acaaagcggg gcgttacacc aacagacgcc ggaaaaattc tctataccca tgcgcgggcc 
0211 attttacgtc agtgtgaaca ggcccaactg gcggtgcata acgttggtca ggcattatcg gggcaagtct 
0281 cgattggctt tgcaccagga accgctgcgt catccatcac catgccctta ttacaggcgg ttcgcgctga 
0351 atttccggag atcgttatct atcttcatga aaatagtggt gcagtgctta acgaaaaatt gataaatcac 
0421 caactcgata tggcggtgat ttatgagcat tcccctgtgg ctggtgtatc cagtcaggct ttgctgaaag 
0491 aagatctttt tctggtagga actcaagatt gcccggggca aagcgttgat gtgaatgcta ttgcgcaaat 
0561 gaacctcttt ctccccagtg attacagtgc tattagactt cgtgttgatg aggctttttc cctacggcga 
0631 ctcacggcaa aagttattgg tgaaattgag tctattgcca cgcttaccgc agcgattgcc agcggcatgg 
0701 gcgttgcagt attacccgaa tcggccgcgc gttcgttatg tggcgcagta aatgggtgga tgtcacgcat 
0771 taccactcct tccatgagtc tctctttgtc attaaattta cccgccagag cgaacttatc gccacaggca 
0841 caggcagtga aagagttgtt aatgtcagtg attagttctc cagtgatgga aaaaaggcag tggcaattgg 
0911 tgagctaagt gttatatcgg gatggaataa gatgcgggtt tttattattt gttatgccgg gcattagact 
0981 ttaacaataa cgggaaatct gaactgcccg gagtttac