MG1655
W3110
Search for
Japanese | English
Gene Report : fhuC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)
Mol Gen Genet. 1998;258(1-2):156-65.
Transport activity of FhuA, FhuC, FhuD, and FhuB derivatives in a system free of polar effects, and stoichiometry of components involved in ferrichrome uptake.
Mademidis A, Koster W. ( 9613584 )
     Deletion OCR33-15 (D)  ,  OCR33-3 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  fhuC
Related strains
     Strains Search Search strains by gene name:  fhuC   Search strains by all related name:  fhuC b0151 ECK0150 JW0147

General information  (Go to Linear View:)
 Gene Name fhuC  
 Alternative name b0151,ECK0150,JW0147  
 Location, Length 169,778 - 170,575 (  +  ) ;   3.66 min ; 798 (bp) ,   265 (aa) Go to Linear View
 Product iron-hydroxamate transporter subunit  
 Operon Name fhuACDB  
 Note ATP-binding component of hydroxymate-dependent iron transport; GO_component: GO:0005737 - cytoplasm  
 Function transport; Transport of small molecules: Cations  
 Gene Ontology GO:0000166 ; nucleotide binding ( fhuC )
GO:0005506 ; iron ion binding ( fhuC )
GO:0005515 ; protein binding ( fhuC )
GO:0005524 ; ATP binding ( fhuC )
GO:0005886 ; plasma membrane ( fhuC )
GO:0006810 ; transport ( fhuC )
GO:0006811 ; ion transport ( fhuC )
GO:0006826 ; iron ion transport ( fhuC )
GO:0016020 ; membrane ( fhuC )
GO:0016887 ; ATPase activity ( fhuC )
GO:0017111 ; nucleoside-triphosphatase activity ( fhuC )
 PID 1786345  
 EC number
  (KEGG Pathway)
 
 
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) FHUC_ECOLI ( P07821 ; P77548 )
    -  Protein name Ferrichrome transport ATP-binding protein fhuC.  
    -  Synonyms  
    -  Gene name Name=fhuC; OrderedLocusNames=b0151;  
    -  Comments
  • FUNCTION:Part of the binding-protein-dependent transport system for iron(III)-ferrichrome. Probably responsible for energy coupling to the transport system.
  • SUBCELLULAR LOCATION:Inner membrane-associated.
  • SIMILARITY:Belongs to the ABC transporter family.  
  •   botton Entry name(Acc.no) Q8FL18 ( Q8FL18 )
        -  Protein name Ferrichrome transport ATP-binding protein fhuC.  
        -  Synonyms  
        -  Gene name Name=fhuC; OrderedLocusNames=c0186;  
        -  Comments
  • SIMILARITY:Belongs to the ABC transporter family.  
  •   botton Entry name(Acc.no) Q8X8Z9 ( Q8X8Z9 )
        -  Protein name ATP-binding component of hydroxymate-dependent iron transport.  
        -  Synonyms  
        -  Gene name Name=fhuC; OrderedLocusNames=z0162;  
        -  Comments
  • SIMILARITY:Belongs to the ABC transporter family.  

  •  Linear View (Whole Mode)
    View Location
       160.0  –  185.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP fhuC (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Crystal Structure Of The Atp-Binding Cassette Of Multisugar Transporter From Pyrococcus Horikoshii Ot3 Complexed With Atp  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Ferrichrome transport ATP-binding protein fhuC  
             PSI-BLAST Phosphate import ATP-binding protein pstB
        nr     (database updated : 2007.02.20 )
             BLAST iron-hydroxamate transporter subunit [Escherichia coli K12]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    ABC_TRANSPORTER     

    Other Cross-Reference
        COG COG1120PH 
        EcoCyc fhuC 

    MMBR References
    J Bacteriol. 1983;156(3):1301-14.
    Cloning and expression of the fhu genes involved in iron(III)-hydroxamate uptake by Escherichia coli.
    Fecker L, Braun V. ( 6315685 )
    Mol Gen Genet. 1983;192(1-2):131-9.
    Plasmid and chromosomal mutants in the iron(III)-aerobactin transport system of Escherichia coli. Use of streptonigrin for selection.
    Braun V, Gross R, Koster W, Zimmermann L. ( 6316109 )
    Mol Gen Genet. 1987;209(1):49-55.
    Nucleotide sequence of the fhuC and fhuD genes involved in iron (III) hydroxamate transport: domains in FhuC homologous to ATP-binding proteins.
    Burkhardt R, Braun V. ( 2823072 )
    J Bacteriol. 1987;169(8):3844-9.
    fhuC and fhuD genes for iron (III)-ferrichrome transport into Escherichia coli K-12.
    Coulton JW, Mason P, Allatt DD. ( 3301821 )

    Sequences
    Amino acid
    FASTA format
    0001 MQEYTNHSDT TFALRNISFR VPGRTLLHPL SLTFPAGKVT GLIGHNGSGK STLLKMLGRH QPPSEGEILL 
    0071 DAQPLESWSS KAFARKVAYL PQQLPPAEGM TVRELVAIGR YPWHGALGRF GAADREKVEE AISLVGLKPL 
    0141 AHRLVDSLSG GERQRAWIAM LVAQDSRCLL LDEPTSALDI AHQVDVLSLV HRLSQERGLT VIAVLHDINM 
    0211 AARYCDYLVA LRGGEMIAQG TPAEIMRGET LEMIYGIPMG ILPHPAGAAP VSFVY
    
    
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp
    -100                                             TCTGGGGCGC AGAACGTCAG GTCGTTGCAA 
    -070 CCGCAACCTT CCGTTTCTAA TTTCTCTTTT GGGGCACGGA TTTCCGTGCC CATTTCACAA GTTGGCTGTT 
    0001 atgcaggaat acacgaatca ttccgatacc acttttgcac tgcgtaatat ctcctttcgt gtgcccgggc 
    0071 gcacgctttt gcatccgctg tcgttaacct ttcctgccgg gaaagtgacc ggtctgattg gtcacaacgg 
    0141 ttctggtaaa tccactctgc tcaaaatgct tggccgtcat cagccgccgt cggaagggga gattcttctt 
    0211 gatgcccaac cgctggaaag ctggagcagc aaagcgtttg cccgcaaagt ggcttatttg ccgcagcagc 
    0281 ttcctccggc agaagggatg accgtgcgtg aactggtggc gattggtcgt tacccgtggc atggcgcgct 
    0351 ggggcgcttt ggggcggcag atcgcgaaaa agtcgaggaa gctatctcgc tggttggctt aaaaccgctg 
    0421 gcgcatcggc tggtcgatag tctctctggc ggcgaacgtc agcgggcgtg gatcgccatg ctggtggcgc 
    0491 aggatagccg ttgtctgttg ctcgacgaac cgacctcggc gctggatatc gcccaccagg ttgatgtgct 
    0561 gtcgctggtg caccgtttaa gtcaggagcg tggcctgacg gtcattgccg tgttgcacga tatcaatatg 
    0631 gcggcacgct actgtgatta tctggtcgcc ctgcgcggcg gtgaaatgat tgctcaggga acgcctgcgg 
    0701 aaattatgcg cggcgaaacc ctcgaaatga tttatggcat cccgatgggt attttgccgc atccggcggg 
    0771 tgctgcacct gtgagttttg tttattgaTG AGCGGCTTAC CTCTTATTTC GCGCCGTCGA CTGTTAACGG 
    0841 CGATGGCGCT TTCTCCGTTG TTATGGCAGA TGAATACCGC CCACGCGGCG GCTATTGA