|
PEC Original Annotations
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|
Essentiality
|
|
Class
|
non-essential
|
|
References (PMID)
|
|
|
Deletion
|
20
(LD)
,
DE(PLK1608)
,
OCR70,L90-6 (LD 20-1_P/O & 20-2TC)
(D)
|
|
Related gene (W3110 PEC)
|
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Gene Search
|
Search MG1655 PEC by gene name:
hipB
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Related strains
|
|
Strains Search
|
Search strains by gene name:
hipB
Search strains by all related name:
hipB b1508 ECK1501 JW1501
|
General information (Go to Linear View: )
|
|
Gene Name
|
hipB
|
|
Alternative name
|
b1508,ECK1501,JW1501
|
|
Location, Length
|
1,590,200 - 1,590,466
(
-
)
;
34.27
min
;
267
(bp) ,
88
(aa)
|
|
Product
|
antitoxin of HipAB toxin-antitoxin system
|
|
Operon Name
|
hipBA
|
|
Note
|
persistence to inhibition of murein or DNA biosynthesis; regulatory protein; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009252 - peptidoglycan biosynthetic process; GO_process: GO:0006259 - DNA metabolic process
|
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Function
|
regulator; Murein sacculus, peptidoglycan
|
|
Gene Ontology
|
GO:0003677
;
DNA binding ( hipB )
GO:0006350
;
transcription ( hipB )
GO:0006355
;
regulation of transcription, DNA-dependent ( hipB )
GO:0043565
;
sequence-specific DNA binding ( hipB )
|
|
PID
|
1787786
|
EC number
(KEGG Pathway)
|
|
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
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EcoGene
|
hipB
(
EG10442
)
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Number of removed
|
0 aa cleaved
|
|
SWISS-PROT
(
Show simple
)
|
Entry name(Acc.no)
|
HIPB_ECOLI
(
P23873
)
|
|
- Protein name
|
HTH-type transcriptional regulator hipB.
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- Synonyms
|
|
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- Gene name
|
Name=hipB; OrderedLocusNames=b1508;
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- Comments
|
FUNCTION:Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' and repress the hip operon promoter.
SUBUNIT:Homodimer. Also associates strongly with hipA.
SIMILARITY:Contains 1 HTH cro/C1-type DNA-binding domain.
|
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Entry name(Acc.no)
|
Q8FHF3
(
Q8FHF3
)
|
|
- Protein name
|
Protein hipB.
|
|
- Synonyms
|
|
|
- Gene name
|
Name=hipB; OrderedLocusNames=c1941;
|
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- Comments
|
SIMILARITY:Contains 1 HTH marR-type DNA-binding domain.
|
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Homology Analysis
|
|
BLAST
|
|
Bacteria
|
|
GTOP
|
hipB
(
homologous genes of other bacterias
)
|
|
PDB
(database updated :
2007.02.20
)
|
|
PSI-BLAST
|
Chain A, Sinr ProteinSINI PROTEIN COMPLEX
|
|
SWISS-PROT
(database updated :
2007.02.20
)
|
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BLAST
|
HTH-type transcriptional regulator hipB
|
|
PSI-BLAST
|
Putative HTH-type transcriptional regulatory protein PF1851
|
|
nr
(database updated :
2007.02.20
)
|
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BLAST
|
DNA-binding transcriptional regulator [Escherichia coli K12]
|
|
Pfam 28.0
(database updated :
2015-05
)
|
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Pfam
|
|
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PROSITE
|
|
PROSITE
|
ASN_GLYCOSYLATION
CK2_PHOSPHO_SITE
MYRISTYL
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MMBR References
|
J Bacteriol. 1991;173(5):1670-6.
HU and integration host factor function as auxiliary proteins in cleavage of phage lambda cohesive ends by terminase.
Mendelson I, Gottesman M, Oppenheim AB.
(
1825651
)
|
J Bacteriol. 1991;173(18):5732-9.
Structure and organization of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.
Black DS, Kelly AJ, Mardis MJ, Moyed HS.
(
1715862
)
|
J Bacteriol. 1994;176:4081-4091
Autoregulation of hip, an operon that affects lethality due to inhibition of peptidoglycan or DNA synthesis.
Black, D. S., B. Irwin, and H. S. Moyed.
|
| Sequences |
Amino acid
FASTA format
|
0001 MMSFQKIYSP TQLANAMKLV RQQNGWTQSE LAKKIGIKQA TISNFENNPD NTTLTTFFKI LQSLELSMTL
0071 CDAKNASPES TEQQNLEW
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 gtagagcgga taagatgtgt ttccagattg
-070 acttatcctc actaaaggat aaaacttata atatcccctt aagcggataa acttgctgtg gacgtatgac
0001 atgatgagct ttcagaagat ctatagccca acgcaattgg cgaatgcaat gaaactggtt cgccagcaaa
0071 atggctggac gcagagcgag ctggcgaaaa aaattggtat taagcaggcg acgatttcca atttcgaaaa
0141 caaccctgac aataccacgc tcacgacatt ttttaagatt ttacagtcgc ttgaactctc aatgacgcta
0211 tgcgacgcga aaaatgcctc gccagaatca acagaacagc aaaatctgga gtggtaatgc ctaaacttgt
0281 cacttggatg aacaaccagc gggtaggcga gttaacgaag ttagccaacg gcgcgcacac ctttaagtat
0351 gcaccggagt ggttagc
|
