MG1655
W3110
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Gene Report : coaE
PEC Original Annotations
Essentiality
     Class essential
     References (PMID)
J Bacteriol. 2001;183(9):2774-8.
Identification of yacE (coaE) as the structural gene for dephosphocoenzyme A kinase in Escherichia coli K-12.
Mishra P, Park PK, Drueckhammer DG. ( 11292795 )
     Deletion OCR31 (D)  ,  OCR31-7 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  coaE
Related strains
     Strains Search Search strains by gene name:  coaE   Search strains by all related name:  coaE b0103 ECK0103 JW0100 yacE

General information  (Go to Linear View:)
 Gene Name coaE  
 Alternative name b0103,ECK0103,JW0100,yacE  
 Location, Length 112,599 - 113,219 (  -  ) ;   2.43 min ; 621 (bp) ,   206 (aa) Go to Linear View
 Product dephospho-CoA kinase  
 Operon Name coaE-yacFG  
 Note putative DNA repair protein  
 Function orf; Not classified  
 Gene Ontology GO:0000166 ; nucleotide binding ( coaE )
GO:0004140 ; dephospho-CoA kinase activity ( coaE )
GO:0005524 ; ATP binding ( coaE )
GO:0005737 ; cytoplasm ( coaE )
GO:0015937 ; coenzyme A biosynthetic process ( coaE )
GO:0016301 ; kinase activity ( coaE )
GO:0016740 ; transferase activity ( coaE )
 PID 1786292  
 EC number
  (KEGG Pathway)   		2.7.1.24  
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) COAE_ECOLI ( P36679 ; P75646 )
    -  Protein name Dephospho-CoA kinase  
    -  Synonyms EC 2.7.1.24, Dephosphocoenzyme A kinase  
    -  Gene name Name=coaE; OrderedLocusNames=b0103, z0113, ECs0107;  
    -  Comments
  • FUNCTION:Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
  • CATALYTIC ACTIVITY:ATP + dephospho-CoA = ADP + CoA.
  • PATHWAY:Coenzyme A (CoA) biosynthesis; fifth (last) step.
  • SUBUNIT:Monomer (Probable).
  • SUBCELLULAR LOCATION:Cytoplasmic (Probable).
  • MISCELLANEOUS:Optimal pH is 8.5.
  • SIMILARITY:Belongs to the coaE family.
  • CAUTION:Ref.1 sequence differs from that shown due to a frameshift in position 160.  
    •   botton Entry name(Acc.no) COAE_ECOL6 ( Q8FL55 )
        -  Protein name Dephospho-CoA kinase  
        -  Synonyms EC 2.7.1.24, Dephosphocoenzyme A kinase  
        -  Gene name Name=coaE; Synonyms=yacE; OrderedLocusNames=c0123;  
        -  Comments
  • FUNCTION:Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity).
  • CATALYTIC ACTIVITY:ATP + dephospho-CoA = ADP + CoA.
  • PATHWAY:Coenzyme A (CoA) biosynthesis; fifth (last) step.
  • SUBUNIT:Monomer (By similarity).
  • SUBCELLULAR LOCATION:Cytoplasmic (By similarity).
  • SIMILARITY:Belongs to the coaE family.  

    •  Linear View (Whole Mode)
    View Location
       100.0  –  125.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP coaE (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Crystal Structure Of Dephospho-Coa Kinase With Adenosine-5'- Diphosphate  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Dephospho-CoA kinase (Dephosphocoenzyme A kinase)  
             PSI-BLAST Dephospho-CoA kinase
        nr     (database updated : 2007.02.20 )
             BLAST dephospho-CoA kinase [Escherichia coli O157:H7 EDL933]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE PKC_PHOSPHO_SITE    MYRISTYL    ATP_GTP_A    UPF0038     

    Other Cross-Reference
        COG COG0237H 
        EcoCyc coaE 

    Sequences
    Amino acid
    FASTA format 
    0001 MRYIVALTGG IGSGKSTVAN AFADLGINVI DADIIARQVV EPGAPALHAI ADHFGANMIA ADGTLQRRAL 
0071 RERIFANPEE KNWLNALLHP LIQQETQHQI QQATSPYVLW VVPLLVENSL YKKANRVLVV DVSPETQLKR 
0141 TMQRDDVTRE HVEQILAAQA TREARLAVAD DVIDNNGAPD AIASDVARLH AHYLQLASQF VSQEKP
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             tttacctggt aaatagtgag cgaacgtttc 
-070 atcaatttcg ctttcgtgca ctcattttta acgttttgat aatcatgatg aattcccggg aatataaatt 
0001 atgaggtata tagttgcctt aacgggaggc attggcagtg gcaagagtac cgttgccaat gcgtttgctg 
0071 atctcggaat taacgtcatt gatgccgata ttattgcgcg tcaggtggtt gaaccaggtg cacctgcgct 
0141 acatgccatt gctgatcact ttggcgctaa catgattgct gctgatggaa cattgcagcg ccgggccttg 
0211 cgcgagcgga tcttcgccaa cccggaagag aaaaactggc ttaacgccct gctgcatccg ctgattcagc 
0281 aagagacgca acaccagatc cagcaagcta cttcccccta tgtactgtgg gttgtgccat tgctggtaga 
0351 aaactcactg tataaaaaag cgaatcgagt gcttgtggtg gatgtcagcc cagaaacgca acttaagcgc 
0421 accatgcagc gcgatgatgt aactcgcgag catgtcgaac aaatccttgc tgctcaggca acgcgcgaag 
0491 cccgccttgc cgtggcagat gacgtcattg ataataacgg cgcaccggat gctatcgcat cggatgttgc 
0561 ccgcctgcac gcacactatt tgcagcttgc gtcgcagttt gtctcacagg aaaaaccgta atgcagaccc 
0631 aggtcctttt tgaacatcca ctaaatgaaa aaatgcgtac atggctgcgc attgagtttt tgattcagca 
0701 actcaccgtt aatttaccca t