MG1655
W3110
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Gene Report : astC
PEC Original Annotations
Essentiality
     Class non-essential
     References (PMID)  
     Deletion LD3-17-1 (LD)  ,  OCL85 (D)  
Related gene (W3110 PEC)
     Gene Search Search MG1655 PEC by gene name:  astC
Related strains
     Strains Search Search strains by gene name:  astC   Search strains by all related name:  astC argM b1748 cstC ECK1746 f406 f406b JW1737 ydjW

General information  (Go to Linear View:)
 Gene Name astC  
 Alternative name argM,b1748,cstC,ECK1746,f406,f406b,JW1737,ydjW  
 Location, Length 1,828,786 - 1,830,006 (  -  ) ;   39.42 min ; 1221 (bp) ,   406 (aa) Go to Linear View
 Product succinylornithine transaminase, PLP-dependent  
 Operon Name astCADBE  
 Note acetylornithine delta-aminotransferase; GO_process: GO:0009063 - cellular amino acid catabolic process  
 Function enzyme; Amino acid biosynthesis: Arginine  
 Gene Ontology GO:0003824 ; catalytic activity ( astC )
GO:0005515 ; protein binding ( astC )
GO:0006525 ; arginine metabolic process ( astC )
GO:0008483 ; transaminase activity ( astC )
GO:0016740 ; transferase activity ( astC )
GO:0019544 ; arginine catabolic process to glutamate ( astC )
GO:0030170 ; pyridoxal phosphate binding ( astC )
GO:0043825 ; succinylornithine transaminase activity ( astC )
 PID 1788044  
 EC number
  (KEGG Pathway)   		2.6.1.11   2.6.1.17  
SWISS-PROT  ( Show simple )
  botton Entry name(Acc.no) ARGD_ECOLI ( P18335 )
    -  Protein name Acetylornithine/succinyldiaminopimelate aminotransferase  
    -  Synonyms EC 2.6.1.11, EC 2.6.1.17, ACOAT, Succinyldiaminopimelate transferase, DapATase  
    -  Gene name Name=argD; Synonyms=dapC, dtu; OrderedLocusNames=b3359;  
    -  Comments
  • FUNCTION:Involved in both the arginine and lysine biosynthetic pathways.
  • CATALYTIC ACTIVITY:N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
  • CATALYTIC ACTIVITY:N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate.
  • COFACTOR:Pyridoxal phosphate.
  • PATHWAY:Arginine biosynthesis; fourth step.
  • PATHWAY:Lysine biosynthesis; diaminopimelate pathway; fourth step.
  • SUBCELLULAR LOCATION:Cytoplasmic (Probable).
  • MISCELLANEOUS:The reaction catalyzed by ACOAT is highly reversible. This enzyme may also transaminate ornithine.
  • SIMILARITY:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.  
    •   botton Entry name(Acc.no) ARGM_ECOLI ( P77581 )
        -  Protein name Succinylornithine transaminase  
        -  Synonyms EC 2.6.1.-, Succinylornithine aminotransferase, Carbon starvation protein C  
        -  Gene name Name=argM; Synonyms=astC, cstC; OrderedLocusNames=b1748;  
        -  Comments
  • FUNCTION:Catalyzes the transmination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as a acetylornithine aminotransferase.
  • COFACTOR:Pyridoxal phosphate.
  • PATHWAY:Arginine catabolism; arginine succinyltransferase pathway; third step.
  • SIMILARITY:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.  
    •   botton Entry name(Acc.no) ARGM_ECOL6 ( Q8FGZ9 )
        -  Protein name Succinylornithine transaminase  
        -  Synonyms EC 2.6.1.-, Succinylornithine aminotransferase  
        -  Gene name Name=argM; Synonyms=astC, cstC; OrderedLocusNames=c2148;  
        -  Comments
  • FUNCTION:Catalyzes the transmination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as a acetylornithine aminotransferase (By similarity).
  • COFACTOR:Pyridoxal phosphate (By similarity).
  • PATHWAY:Arginine catabolism; arginine succinyltransferase pathway; third step.
  • SIMILARITY:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.  
    •   botton Entry name(Acc.no) ARGM_ECO57 ( Q8X598 )
        -  Protein name Succinylornithine transaminase  
        -  Synonyms EC 2.6.1.-, Succinylornithine aminotransferase  
        -  Gene name Name=argM; Synonyms=astC, cstC; OrderedLocusNames=z2780, ECs2454;  
        -  Comments
  • FUNCTION:Catalyzes the transmination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as a acetylornithine aminotransferase (By similarity).
  • COFACTOR:Pyridoxal phosphate (By similarity).
  • PATHWAY:Arginine catabolism; arginine succinyltransferase pathway; third step.
  • SIMILARITY:Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.  

    •  Linear View (Whole Mode)
    View Location
       1820.0  –  1845.0 (KBP)

    Homology Analysis
    BLAST
        Bacteria
             GTOP astC (  homologous genes of other bacterias  )  
        PDB     (database updated : 2007.02.20 )
             PSI-BLAST Chain A, Ornithine Aminotransferase Py00104 From Plasmodium Yoelii  
        SWISS-PROT     (database updated : 2007.02.20 )
             BLAST Succinylornithine transaminase  
             PSI-BLAST Acetylornithine aminotransferase
        nr     (database updated : 2007.02.20 )
             BLAST succinylornithine transaminase, PLP-dependent [Escherichia coli K12]  
    Pfam 28.0   (database updated : 2015-05 )
        Pfam
    PROSITE
        PROSITE ASN_GLYCOSYLATION    PKC_PHOSPHO_SITE    CK2_PHOSPHO_SITE    TYR_PHOSPHO_SITE    MYRISTYL    AA_TRANSFER_CLASS_3     

    Other Cross-Reference
        COG COG4992E 
        EcoCyc astC 

    Sequences
    Amino acid
    FASTA format 
    0001 MSQPITRENF DEWMIPVYAP APFIPVRGEG SRLWDQQGKE YIDFAGGIAV NALGHAHPEL REALNEQASK 
0071 FWHTGNGYTN EPVLRLAKKL IDATFADRVF FCNSGAEANE AALKLARKFA HDRYGSHKSG IVAFKNAFHG 
0141 RTLFTVSAGG QPAYSQDFAP LPADIRHAAY NDINSASALI DDSTCAVIVE PIQGEGGVVP ASNAFLQGLR 
0211 ELCNRHNALL IFDEVQTGVG RTGELYAYMH YGVTPDLLTT AKALGGGFPV GALLATEECA RVMTVGTHGT 
0281 TYGGNPLASA VAGKVLELIN TPEMLNGVKQ RHDWFVERLN TINHRYGLFS EVRGLGLLIG CVLNADYAGQ 
0351 AKQISQEAAK AGVMVLIAGG NVVRFAPALN VSEEEVTTGL DRFAAACEHF VSRGSS
    Nucleotide
    FASTA format

    View sequence out neighbor 100bp 
    -100                                             tttatcactg gctggcacga accctgcaat 
-070 ctacatttac agcgcaaaca ttacttatta ttaacatata aataacgaat tatttactgt agaggtcgct 
0001 atgtctcagc caattacgcg tgaaaacttt gatgaatgga tgatacctgt ttacgctccg gcacccttta 
0071 taccggtacg tggcgaaggt tcgcgcttgt gggatcagca ggggaaagag tatatcgact tcgcgggtgg 
0141 cattgcggtg aacgcgctgg gccatgcgca tccggaactg cgtgaagcgc tgaacgaaca ggcgagtaag 
0211 ttctggcata ccggcaacgg ttacaccaac gagccggtac tgcgactggc gaaaaaattg atcgacgcca 
0281 cgtttgccga tcgcgtcttc ttttgtaact ccggtgcgga agccaacgaa gcggcgctaa aactggcgcg 
0351 taaattcgct cacgaccgct acggcagcca taagagcggc atcgtggcgt tcaaaaatgc gtttcatggt 
0421 cgcacgctgt ttactgtcag tgcgggtggg cagccagcct attcacagga ttttgcgcca ctgccggcgg 
0491 atattcgtca tgctgcatat aacgatatta actctgccag cgcgctgatt gacgactcta cctgtgcggt 
0561 gattgtcgaa cccatccagg gggaaggcgg tgtggtgcca gccagcaacg cgtttttaca aggtctgcgt 
0631 gaattgtgta accgccacaa tgcgctgttg atttttgatg aagtacaaac cggcgtcggg cgcaccgggg 
0701 aactgtatgc ctatatgcac tacggcgtga cgcctgatct gttaactacc gccaaagcgc tgggcggcgg 
0771 tttcccggtc ggtgcgttgt tggcaaccga agagtgcgcc cgcgtgatga ccgttggcac tcatggcacc 
0841 acctatggcg gtaatccgct ggcctcggcg gtggcaggca aagtgctgga gctcatcaac acaccagaga 
0911 tgcttaatgg cgttaaacag cgtcacgact ggtttgttga gcgtcttaat actattaatc accgctatgg 
0981 tttgttcagt gaagttcgcg gcttaggttt gctgattggc tgtgtactga atgccgatta cgccgggcaa 
1051 gcgaaacaga tctctcagga agcggcgaaa gcaggcgtga tggtactgat tgcgggtggc aacgtggtgc 
1121 gttttgcgcc tgcgctcaat gtcagcgaag aagaggtgac gaccggactg gatcgctttg cagctgcttg 
1191 cgaacacttt gttagccgag gttcatcatg atggtcatcc gtcccgttga gcgatcagat gtctcggcgc 
1261 tgatgcagct tgccagcaaa acgggcggcg gcctgacgtc gcttcccgcc aatgaagcca c