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PEC Original Annotations
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Essentiality
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Class
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essential
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References (PMID)
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Mol Microbiol. 1997;24(6):1263-73.
ftsW is an essential cell-division gene in Escherichia coli.
Boyle DS, Khattar MM, Addinall SG, Lutkenhaus J, Donachie WD.
(
9218774
)
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Deletion
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OCR30,31-3 (BK2-1 / AK1-1)
(D)
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
ftsW
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Related strains
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Strains Search
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Search strains by gene name:
ftsW
Search strains by all related name:
ftsW b0089 ECK0090 JW0087
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General information (Go to Linear View: )
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Gene Name
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ftsW
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Alternative name
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b0089,ECK0090,JW0087
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Location, Length
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98,403 - 99,647
(
+
)
;
2.12
min
;
1245
(bp) ,
414
(aa)
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Product
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lipid II flippase; integral membrane protein involved in stabilizing FstZ ring during cell division
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Operon Name
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mraZ-rsmH-ftsLI-murEF-mraY-murD-ftsW-murGC-ddlB-ftsQAZ-lpxC
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Note
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cell division; membrane protein involved in shape determination; GO_component: GO:0009274 - peptidoglycan-based cell wall; GO_component: GO:0019866 - organelle inner membrane
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Function
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membrane; Cell division
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Gene Ontology
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GO:0005886
;
plasma membrane ( ftsW )
GO:0007047
;
cell wall organization and biogenesis ( ftsW )
GO:0007049
;
cell cycle ( ftsW )
GO:0008360
;
regulation of cell shape ( ftsW )
GO:0009252
;
peptidoglycan biosynthetic process ( ftsW )
GO:0016020
;
membrane ( ftsW )
GO:0016021
;
integral to membrane ( ftsW )
GO:0051301
;
cell division ( ftsW )
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PID
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1786277
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show simple
)
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Entry name(Acc.no)
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FTSW_ECOLI
(
P16457
)
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- Protein name
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Cell division protein ftsW.
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- Synonyms
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- Gene name
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Name=ftsW; OrderedLocusNames=b0089, c0107, z0099, ECs0093;
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- Comments
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FUNCTION:This is a septum-peptidoglycan biosynthetic protein, involved in cell wall formation. Plays a role in the stabilization of the ftsZ ring during cell division.
SUBCELLULAR LOCATION:Integral membrane protein. Inner membrane.
SIMILARITY:Belongs to the ftsW/rodA/spoVE family.
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Homology Analysis
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BLAST
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Bacteria
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GTOP
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ftsW
(
homologous genes of other bacterias
)
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PDB
(database updated :
2007.02.20
)
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PSI-BLAST
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SWISS-PROT
(database updated :
2007.02.20
)
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BLAST
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Cell division protein ftsW
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PSI-BLAST
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Cell division protein ftsW
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nr
(database updated :
2007.02.20
)
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BLAST
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Cell division protein ftsW [Escherichia coli CFT073]
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Pfam 28.0
(database updated :
2015-05
)
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Pfam
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PROSITE
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PROSITE
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CAMP_PHOSPHO_SITE
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
MYRISTYL
AMIDATION
PHOSPHOPANTETHEINE
FTSW_RODA_SPOVE
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MMBR References
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J Bacteriol. 1989;171(11):6375-8.
Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.
Ikeda M, Sato T, Wachi M, Jung HK, Ishino F, Kobayashi Y, Matsuhashi M.
(
2509435
)
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J Bacteriol. 1989;171(11):6379-82.
Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes.
Jung HK, Ishino F, Matsuhashi M.
(
2553679
)
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J Bacteriol. 1994;176:7140-7147
Identification of FtsW and characterization of a new ftsW division mutant of Escherichia coli.
Khattar, M. M., K. J. Begg, and W. D. Donachie.
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J Bacteriol. 1997;179:784-793
Two polypeptide products of the Escherichia coli cell division gene ftsW and a possible role for FtsW in FtsZ function.
Khattar, M. M., S. G. Addinall, K. H. Stedul, D. S. Boyle, J. Lutkenhaus, and W. D. Donachie.
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| Sequences |
Amino acid
FASTA format
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0001 MRLSLPRLKM PRLPGFSILV WISTALKGWV MGSREKDTDS LIMYDRTLLW LTFGLAAIGF IMVTSASMPI
0071 GQRLTNDPFF FAKRDGVYLI LAFILAIITL RLPMEFWQRY SATMLLGSII LLMIVLVVGS SVKGASRWID
0141 LGLLRIQPAE LTKLSLFCYI ANYLVRKGDE VRNNLRGFLK PMGVILVLAV LLLAQPDLGT VVVLFVTTLA
0211 MLFLAGAKLW QFIAIIGMGI SAVVLLILAE PYRIRRVTAF WNPWEDPFGS GYQLTQSLMA FGRGELWGQG
0281 LGNSVQKLEY LPEAHTDFIF AIIGEELGYV GVVLALLMVF FVAFRAMSIG RKALEIDHRF SGFLACSIGI
0351 WFSFQALVNV GAAAGMLPTK GLTLPLISYG GSSLLIMSTA IMMLLRIDYE TRLEKAQAFV RGSR
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 ATATGGTTCT GCTCTCCCCA GCCTGTGCCA
-070 GCCTTGATCA GTTCAAGAAC TTTGAACAAC GAGGCAATGA GTTTGCCCGT CTGGCGAAGG AGTTAGGTTG
0001 atgcgtttat ctctccctcg cctgaaaatg ccgcgcctgc caggattcag tatcctggtc tggatctcca
0071 cggcgctaaa gggctgggtg atgggctcgc gggaaaaaga taccgacagc ctgatcatgt acgatcgcac
0141 cttactgtgg ctgaccttcg gcctcgcggc gattggcttt atcatggtga cctcggcgtc aatgcccata
0211 gggcaacgct taaccaacga tccgttcttc ttcgcgaagc gtgatggtgt ctatctgatt ttggcgttta
0281 ttctggcgat cattacgctg cgtctgccga tggagttctg gcaacgctac agtgccacga tgctgctcgg
0351 atctatcatc ctgctgatga tcgtcctggt agtgggtagc tcggttaaag gggcatcgcg ttggatcgat
0421 ctcggtttgc tgcgtatcca gcctgcggag ctgacaaaac tgtcgctgtt ttgctatatc gccaactatc
0491 tggtgcgtaa aggcgacgaa gtacgtaata acctgcgcgg cttcctgaaa ccgatgggcg tgattctggt
0561 gttggcagtg ttactgctgg cacagccaga ccttggtacg gtggtggtgt tgtttgtgac tacgctggcg
0631 atgttgttcc tggcgggagc gaaattgtgg cagttcattg ccattatcgg tatgggcatt tcagcggttg
0701 tgttgctgat actcgccgaa ccgtaccgta tccgccgtgt taccgcattc tggaacccgt gggaagatcc
0771 ctttggcagc ggctatcagt taacgcaatc gctgatggcg tttggtcgcg gcgaactttg ggggcaaggt
0841 ttaggtaact cggtacaaaa actggagtat ctgccggaag cgcacactga ctttattttc gccattatcg
0911 gcgaagaact ggggtatgtc ggtgtggtgc tggcactttt aatggtattc ttcgtcgctt ttcgcgcgat
0981 gtcgattggc cgtaaagcat tagaaattga ccaccgtttt tccggttttc tcgcctgttc tattggcatc
1051 tggtttagct tccaggcgct ggttaacgta ggcgcggcgg cggggatgtt accgaccaaa ggtctgacat
1121 tgccgctgat cagttacggt ggttcgagct tactgattat gtcgacagcc atcatgatgc tgttgcgtat
1191 tgattatgaa acgcgtctgg agaaagcgca ggcgtttgta cgaggttcac gatgaGTGGT CAAGGAAAGC
1261 GATTAATGGT GATGGCAGGC GGAACCGGTG GACATGTATT CCCGGGACTG GCGGTTGCGC ACCATCTAAT
1331 GGCTCAGGGT TGGCA
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