PEC Original Annotations
|
Essentiality
|
Class
|
non-essential
|
References (PMID)
|
Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
|
|
Deletion
|
OCR04
(D)
|
Related gene (W3110 PEC)
|
Gene Search
|
Search MG1655 PEC by gene name:
metE
|
Related strains
|
Strains Search
|
Search strains by gene name:
metE
Search strains by all related name:
metE b3829 ECK3823 JW3805 metB12
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General information (Go to Linear View:)
|
Gene Name
|
metE
|
Alternative name
|
b3829,ECK3823,JW3805,metB12
|
Location, Length
|
4,011,076 - 4,013,337
(
+
)
;
86.45
min
;
2262
(bp) ,
753
(aa)
|
Product
|
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase
|
Operon Name
|
metE
|
Note
|
tetrahydropteroyltriglutamate methyltransferase; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0009086 - methionine biosynthetic process; GO_process: GO:0006556 - S-adenosylmethionine biosynthetic process
|
Function
|
enzyme; Amino acid biosynthesis: Methionine
|
Gene Ontology
|
GO:0003871
;
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity ( metE )
GO:0005515
;
protein binding ( metE )
GO:0008168
;
methyltransferase activity ( metE )
GO:0008270
;
zinc ion binding ( metE )
GO:0008652
;
amino acid biosynthetic process ( metE )
GO:0009086
;
methionine biosynthetic process ( metE )
GO:0016740
;
transferase activity ( metE )
GO:0046872
;
metal ion binding ( metE )
|
PID
|
2367304
|
EC number
(KEGG Pathway)
|
2.1.1.14
|
Verified Protein Starts
(data
compiled from literature and appropriate citations are available from EcoGene)
|
EcoGene
|
metE
(
EG10584
)
|
Number of removed
|
1 aa cleaved
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
METE_ECOLI
(
P25665
)
|
- Protein name
|
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
|
- Synonyms
|
EC 2.1.1.14, Methionine synthase, vitamin-B12 independent isozyme, Cobalamin-independent methionine synthase
|
- Gene name
|
Name=metE; OrderedLocusNames=b3829;
|
MMBR References
|
Mol Gen Genet. 1988;211(1):78-87.
Cloning and characterization of the genes for the two homocysteine transmethylases of Escherichia coli.
Old IG, Hunter MG, Wilson DT, Knight SM, Weatherston CA, Glass RE.
(
2830470
)
|
J Mol Biol. 1988;200(3):427-38.
Generation of a detailed physical and genetic map of the ilv-metE-udp region of the Escherichia coli chromosome.
Aldea M, Maples VF, Kushner SR.
(
3294419
)
|
Sov. Genet. (Engl. Transl. Genetika) 1981;17:1127-1133.
Regulation of the activity of the uridine phosphorylase of Escherichia coli K-12. I. Mapping of mutations for the structural gene and determination of the direction of transcription.
Alkhimova, R. A., A. S. Mironov, and V. V. Sukhodolets.
|
Science. 1992;257(5071):771-8.
Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes.
Daniels DL, Plunkett G 3rd, Burland VD, Blattner FR.
(
1379743
)
|
Sequences |
Amino acid
FASTA format
|
0001 MTILNHTLGF PRVGLRRELK KAQESYWAGN STREELLAVG RELRARHWDQ QKQAGIDLLP VGDFAWYDHV
0071 LTTSLLLGNV PARHQNKDGS VDIDTLFRIG RGRAPTGEPA AAAEMTKWFN TNYHYMVPEF VKGQQFKLTW
0141 TQLLDEVDEA LALGHKVKPV LLGPVTWLWL GKVKGEQFDR LSLLNDILPV YQQVLAELAK RGIEWVQIDE
0211 PALVLELPQA WLDAYKPAYD ALQGQVKLLL TTYFEGVTPN LDTITALPVQ GLHVDLVHGK DDVAELHKRL
0281 PSDWLLSAGL INGRNVWRAD LTEKYAQIKD IVGKRDLWVA SSCSLLHSPI DLSVETRLDA EVKSWFAFAL
0351 QKCHELALLR DALNSGDTAA LAEWSAPIQA RRHSTRVHNP AVEKRLAAIT AQDSQRANVY EVRAEAQRAR
0421 FKLPAWPTTT IGSFPQTTEI RTLRLDFKKG NLDANNYRTG IAEHIKQAIV EQERLGLDVL VHGEAERNDM
0491 VEYFGEHLDG FVFTQNGWVQ SYGSRCVKPP IVIGDISRPA PITVEWAKYA QSLTDKPVKG MLTGPVTILC
0561 WSFPREDVSR ETIAKQIALA LRDEVADLEA AGIGIIQIDE PALREGLPLR RSDWDAYLQW GVEAFRINAA
0631 VAKDDTQIHT HMCYCEFNDI MDSIAALDAD VITIETSRSD MELLESFEEF DYPNEIGPGV YDIHSPNVPS
0701 VEWIEALLKK AAKRIPAERL WVNPDCGLKT RGWPETRAAL ANMVQAAQNL RRG
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CCCGGTCACT TACTTCAGTA AGCTCCCGGG
-070 GATGAATAAA CTTGCCGCCT TCCCTAAATT CAAAATCCAT AGGATTTACA TATAATTAGA GGAAGAAAAA
0001 atgacaatat tgaatcacac cctcggtttc cctcgcgttg gcctgcgtcg cgagctgaaa aaagcgcaag
0071 aaagttattg ggcggggaac tccacgcgtg aagaactgct ggcggtaggg cgtgaattgc gtgctcgtca
0141 ctgggatcaa caaaagcaag cgggtatcga cctgctgccg gtgggcgatt ttgcctggta cgatcatgta
0211 ctgaccacca gtctgctgct gggtaacgtt ccggcgcgtc atcagaacaa agatggttcg gtagatatcg
0281 acaccctgtt ccgtattggt cgtggacgtg cgccgactgg cgaacctgcg gcggcagcgg aaatgaccaa
0351 atggtttaac accaactatc actacatggt gccggagttc gttaaaggcc aacagttcaa actgacctgg
0421 acgcagctgc tggacgaagt ggacgaggcg ctggcgctgg gccacaaggt gaaacctgtg ctgctggggc
0491 cggttacctg gctgtggctg gggaaagtga aaggtgaaca atttgaccgc ctgagcctgc tgaacgacat
0561 tctgccggtt tatcagcaag tgctggcaga actggcgaaa cgcggcatcg agtgggtaca gattgatgaa
0631 cccgcgctgg tactggaact accacaggcg tggctggacg catacaaacc cgcttacgac gcgctccagg
0701 gacaggtgaa actgctgctg accacctatt ttgaaggcgt aacgccaaat ctcgacacga ttactgcgct
0771 gcctgttcag ggtctgcatg ttgacctcgt acatggtaaa gatgacgttg ctgaactgca caagcgcctg
0841 ccttctgact ggttgctgtc tgcgggtctg atcaatggtc gtaacgtctg gcgcgccgat cttaccgaga
0911 aatatgcgca aattaaggac attgtcggca aacgtgattt gtgggtggca tcttcctgct cgttgctgca
0981 cagccccatc gacctgagcg tggaaacgcg tcttgatgca gaagtgaaaa gctggtttgc cttcgcccta
1051 caaaaatgcc atgaactggc actgctgcgc gatgcgctga acagtggtga cacggcagct ctggcagagt
1121 ggagcgcccc gattcaggca cgtcgtcact ctacccgcgt acataatccg gcggtagaaa agcgtctggc
1191 ggcgatcacc gcccaggaca gccagcgtgc gaatgtctat gaagtgcgtg ctgaagccca gcgtgcgcgt
1261 tttaaactgc cagcgtggcc gaccaccacg attggttcct tcccgcaaac cacggaaatt cgtaccctgc
1331 gtctggattt caaaaagggc aatctcgacg ccaacaacta ccgcacgggc attgcggaac atatcaagca
1401 ggccattgtt gagcaggaac gtttgggact ggatgtgctg gtacatggcg aggccgagcg taatgacatg
1471 gtggaatact ttggcgagca cctcgacgga tttgtcttta cgcaaaacgg ttgggtacag agctacggtt
1541 cccgctgcgt gaagccaccg attgtcattg gtgacattag ccgcccggca ccgattaccg tggagtgggc
1611 gaagtatgcg caatcgctga ccgacaaacc ggtgaaaggg atgctgacgg ggccggtgac catactctgc
1681 tggtcgttcc cgcgtgaaga tgtcagccgt gaaaccatcg ccaaacagat tgcgctggcg ctgcgtgatg
1751 aagtggccga tctggaagcc gctggaattg gcatcatcca gattgacgaa ccggcgctgc gcgaaggttt
1821 accgctgcgt cgtagcgact gggatgcgta tctccagtgg ggcgtagagg ccttccgtat caacgccgcc
1891 gtggcgaaag atgacacaca aatccacact cacatgtgtt attgcgagtt caacgacatc atggattcga
1961 ttgcggcgct ggacgcagac gtcatcacca tcgaaacctc gcgttccgac atggagttgc tggagtcgtt
2031 tgaagagttt gattatccaa atgaaatcgg tcctggcgtc tatgacattc actcgccaaa cgtaccgagc
2101 gtggaatgga ttgaagcctt gctgaagaaa gcggcaaaac gcattccggc agagcgcctg tgggtcaacc
2171 cggactgtgg cctgaaaacg cgcggctggc cagaaacccg cgcggcactg gcgaacatgg tgcaggcggc
2241 gcagaacttg cgtcgggggt aaAATCCAAA CCGGGTGGTA ATACCACCCG GTCTTTTCTC ATTACAGCGA
2311 CTTCTTCCCA CCATACTGCT TAAACCATTC CAGCATACGC TGCCAGCCAT CT
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