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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Deletion
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OCR12
(D)
,
DE(xylE-malB)262
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Related gene (W3110 PEC)
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Gene Search
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Search MG1655 PEC by gene name:
malK
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Related strains
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Strains Search
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Search strains by gene name:
malK
Search strains by all related name:
malK b4035 ECK4027 JW3995 o371
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General information (Go to Linear View: )
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Gene Name
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malK
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Alternative name
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b4035,ECK4027,JW3995,o371
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Location, Length
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4,244,807 - 4,245,922
(
+
)
;
91.49
min
;
1116
(bp) ,
371
(aa)
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Product
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fused maltose transport subunit, ATP-bindingcomponent of ABC superfamily/regulatory protein
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Operon Name
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malK-lamB-malM
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Note
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ATP-binding component of transport system for maltose; GO_component: GO:0005737 - cytoplasm; GO_process: GO:0016052 - carbohydrate catabolic process
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Function
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transport; Transport of small molecules: Carbohydrates, organic acids, alcohols
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Gene Ontology
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GO:0000166
;
nucleotide binding ( malK )
GO:0005215
;
transporter activity ( malK )
GO:0005351
;
sugar:hydrogen ion symporter activity ( malK )
GO:0005524
;
ATP binding ( malK )
GO:0005886
;
plasma membrane ( malK )
GO:0006810
;
transport ( malK )
GO:0008643
;
carbohydrate transport ( malK )
GO:0015423
;
maltose-transporting ATPase activity ( malK )
GO:0015609
;
maltooligosaccharide-importing ATPase activity ( malK )
GO:0016020
;
membrane ( malK )
GO:0016787
;
hydrolase activity ( malK )
GO:0016820
;
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances ( malK )
GO:0016887
;
ATPase activity ( malK )
GO:0017111
;
nucleoside-triphosphatase activity ( malK )
GO:0043190
;
ATP-binding cassette (ABC) transporter complex ( malK )
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PID
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1790467
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EC number
(KEGG Pathway)
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SWISS-PROT
(
Show details
[
1
more]
)
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Entry name(Acc.no)
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MALK_ECOLI
(
P02914
;
Q47348
)
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- Protein name
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Maltose/maltodextrin transport ATP-binding protein malK.
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- Synonyms
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- Gene name
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Name=malK; OrderedLocusNames=b4035, z5633, ECs5018;
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MMBR References
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J Bacteriol. 1980;144(1):7-11.
Methyl-alpha-maltoside and 5-thiomaltose: analogs transported by the Escherichia coli maltose transport system.
Ferenci T.
(
6998971
)
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Nucleic Acids Res. 1982;10:7449-7458
Sequence of the malK gene in E. coli K12.
Gilson, E., H. Nikaido, and M. Hofnung.
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J Bacteriol. 1993;175:6546-6552
Functional exchangeability of the ABC proteins of the periplasmic binding protein-dependent transport systems Ugp and Mal of Escherichia coli.
Hekstra, D., and J. Tommassen.
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J Mol Biol. 1983;170(4):861-82.
Mutations in the promoter regions of the malEFG and malK-lamB operons of Escherichia coli K12.
Bedouelle H.
(
6417341
)
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Mol Gen Genet. 1982;185(1):82-7.
A DNA sequence containing the control regions of the malEFG and malK-lamB operons in Escherichia coli K12.
Bedouelle H, Hofnung M.
(
6283312
)
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J Mol Biol. 1982;161(4):519-31.
Promoters of the malEFG and malK-lamB operons in Escherichia coli K12.
Bedouelle H, Schmeissner U, Hofnung M, Rosenberg L.
(
6185687
)
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J. Biochem. (Tokyo) 1983;94:243-247
Nucleotide sequence of the regulatory region of malB operons in E. coli.
Ohsumi, M., T. Sekiya, S. Nishimura, and M. Ohki.
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J Bacteriol. 1978;133(3):1358-67.
Permease-specific mutations in Salmonella typhimurium and Escherichia coli that release the glycerol, maltose, melibiose, and lactose transport systems from regulation by the phosphoenolpyruvate:sugar phosphotransferase system.
Saier MH Jr, Straud H, Massman LS, Judice JJ, Newman MJ, Feucht BU.
(
346569
)
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Genetics 1972;71:207-216
On some genetic aspects of phage lambda resistance in E. coli K12.
Thirion, J. P., and M. Hofnung.
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Mol Gen Genet. 1981;184(3):479-83.
rho Mutations restore lamB expression in E. coli K12 strains with an inactive malB region.
Colonna B, Hofnung M.
(
6278260
)
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| Sequences |
Amino acid
FASTA format
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0001 MASVQLQNVT KAWGEVVVSK DINLDIHEGE FVVFVGPSGC GKSTLLRMIA GLETITSGDL FIGEKRMNDT
0071 PPAERGVGMV FQSYALYPHL SVAENMSFGL KLAGAKKEVI NQRVNQVAEV LQLAHLLDRK PKALSGGQRQ
0141 RVAIGRTLVA EPSVFLLDEP LSNLDAALRV QMRIEISRLH KRLGRTMIYV THDQVEAMTL ADKIVVLDAG
0211 RVAQVGKPLE LYHYPADRFV AGFIGSPKMN FLPVKVTATA IDQVQVELPM PNRQQVWLPV ESRDVQVGAN
0281 MSLGIRPEHL LPSDIADVIL EGEVQVVEQL GNETQIHIQI PSIRQNLVYR QNDVVLVEEG ATFAIGLPPE
0351 RCHLFREDGT ACRRLHKEPG V
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Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 AAGCCAGGGG GTGGAGGATT TAAGCCATCT
-070 CCTGATGACG CATAGTCAGC CCATCATGAA TGTTGCTGTC GATGACAGGT TGTTACAAAG GGAGAAGGGC
0001 atggcgagcg tacagctgca aaatgtaacg aaagcctggg gcgaggtcgt ggtatcgaaa gatatcaatc
0071 tcgatatcca tgaaggtgaa ttcgtggtgt ttgtcggacc gtctggctgc ggtaaatcga ctttactgcg
0141 catgattgcc gggcttgaga cgatcaccag cggcgacctg ttcatcggtg agaaacggat gaatgacact
0211 ccgccagcag aacgcggcgt tggtatggtg tttcagtctt acgcgctcta tccccacctg tcagtagcag
0281 aaaacatgtc atttggcctg aaactggctg gcgcaaaaaa agaggtgatt aaccaacgcg ttaaccaggt
0351 ggcggaagtg ctacaactgg cgcatttgct ggatcgcaaa ccgaaagcgc tctccggtgg tcagcgtcag
0421 cgtgtggcga ttggccgtac gctggtggcc gagccaagcg tatttttgct cgatgaaccg ctctccaacc
0491 tcgatgctgc actgcgtgtg caaatgcgta tcgaaatctc ccgtctgcat aaacgcctgg gccgcacaat
0561 gatttacgtc acccacgatc aggtcgaagc gatgacgctg gccgacaaaa tcgtggtgct ggacgccggt
0631 cgcgtggcgc aggttgggaa accgctggag ctgtaccact atccggcaga ccgttttgtc gccggattta
0701 tcggttcgcc aaagatgaac ttcctgccgg taaaagtgac cgccaccgca atcgatcaag tgcaggtgga
0771 gctgccgatg ccaaatcgtc agcaagtctg gctgccagtt gaaagccgtg atgtccaggt tggagccaat
0841 atgtcgctgg gtattcgccc ggaacatcta ctgccgagtg atatcgctga cgtcatcctt gagggtgaag
0911 ttcaggtcgt cgagcaactc ggcaacgaaa ctcaaatcca tatccagatc ccttccattc gtcaaaacct
0981 ggtgtaccgc cagaacgacg tggtgttggt agaagaaggt gccacattcg ctatcggcct gccgccagag
1051 cgttgccatc tgttccgtga ggatggcact gcatgtcgtc gactgcataa ggagccgggc gtttaaGCAC
1121 CCCACAAAAC ACACAAAGCC TGTCACAGGT GATGTGAAAA AAGAAAAGCA ATGACTCAGG AGATAGAATG
1191 ATGATTACTC TGCGCAAACT TCCTCT
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