PEC Original Annotations
|
Essentiality
|
Class
|
non-essential
|
References (PMID)
|
|
Deletion
|
OCL18,19-1
(D)
,
DE(bioH-asd)29
|
Related gene (W3110 PEC)
|
Gene Search
|
Search MG1655 PEC by gene name:
malT
|
Related strains
|
Strains Search
|
Search strains by gene name:
malT
Search strains by all related name:
malT b3418 ECK3405 JW3381 malA o901
|
General information (Go to Linear View: )
|
Gene Name
|
malT
|
Alternative name
|
b3418,ECK3405,JW3381,malA,o901
|
Location, Length
|
3,551,107 - 3,553,812
(
+
)
;
76.54
min
;
2706
(bp) ,
901
(aa)
|
Product
|
DNA-binding transcriptional activator for the mal regulon and maltotriose-ATP-binding protein
|
Operon Name
|
malT
|
Note
|
positive regulator of mal regulon; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0016052 - carbohydrate catabolic process; GO_process: GO:0006350 - transcription
|
Function
|
regulator; Degradation of small molecules: Carbon compounds
|
Gene Ontology
|
GO:0000166
;
nucleotide binding ( malT )
GO:0003677
;
DNA binding ( malT )
GO:0003700
;
transcription factor activity ( malT )
GO:0005488
;
binding ( malT )
GO:0005524
;
ATP binding ( malT )
GO:0005622
;
intracellular ( malT )
GO:0005975
;
carbohydrate metabolic process ( malT )
GO:0006350
;
transcription ( malT )
GO:0006355
;
regulation of transcription, DNA-dependent ( malT )
GO:0043565
;
sequence-specific DNA binding ( malT )
GO:0045893
;
positive regulation of transcription, DNA-dependent ( malT )
GO:0045913
;
positive regulation of carbohydrate metabolic process ( malT )
|
PID
|
2367223
|
EC number
(KEGG Pathway)
|
|
SWISS-PROT
(
Show details
[
2
more]
)
|
Entry name(Acc.no)
|
MALT_ECOLI
(
P06993
)
|
- Protein name
|
HTH-type transcriptional regulator malT
|
- Synonyms
|
ATP-dependent transcriptional activator malT
|
- Gene name
|
Name=malT; Synonyms=malA; OrderedLocusNames=b3418;
|
Homology Analysis
|
BLAST
|
Bacteria
|
GTOP
|
malT
(
homologous genes of other bacterias
)
|
PDB
(database updated :
2007.02.20
)
|
PSI-BLAST
|
Chain A, Crystal Structure Of Transcription Factor Malt Domain Iii
|
SWISS-PROT
(database updated :
2007.02.20
)
|
BLAST
|
HTH-type transcriptional regulator malT
|
PSI-BLAST
|
Chaperone clpB
|
nr
(database updated :
2007.02.20
)
|
BLAST
|
transcriptional regulator MalT [Escherichia coli K12]
|
Pfam 28.0
(database updated :
2015-05
)
|
Pfam
|
|
PROSITE
|
PROSITE
|
ASN_GLYCOSYLATION
PKC_PHOSPHO_SITE
CK2_PHOSPHO_SITE
TYR_PHOSPHO_SITE
MYRISTYL
AMIDATION
RGD
HTH_LUXR_FAMILY
|
MMBR References
|
J Bacteriol. 1980;144(1):7-11.
Methyl-alpha-maltoside and 5-thiomaltose: analogs transported by the Escherichia coli maltose transport system.
Ferenci T.
(
6998971
)
|
Mol Gen Genet. 1976;145(2):207-13.
lamB mutations in E. coli K12: growth of lambda host range mutants and effect of nonsense suppressors.
Hofnung M, Jezierska A, Braun-Breton C.
(
778586
)
|
J Bacteriol. 1981;148(3):853-60.
General method for fine mapping of the Escherichia coli K-12 lamB gene: localization of missense mutations affecting bacteriophage lambda adsorption.
Hofnung M, Lepouce E, Braun-Breton C.
(
6458595
)
|
Mol Gen Genet. 1971;112(2):117-32.
Mutations allowing growth on maltose of Escherichia coli K 12 strains with a deleted malT gene.
Hofnung M, Schwartz M.
(
4940111
)
|
J Mol Biol. 1971;61(3):681-94.
Complementation studies in the maltose-A region of the Escherichia coli K12 genetic map.
Hofnung M, Schwartz M, Hatfield D.
(
4943758
)
|
Res Microbiol. 1991;142(9):937-42.
Genetic studies on the promoter of malT, the gene that encodes the activator of the Escherichia coli maltose regulon.
Raibaud O, Vidal-Ingigliardi D, Kolb A.
(
1666689
)
|
J Bacteriol. 1980;143(2):761-71.
Restriction map of the Escherichia coli malA region and identification of the malT product.
Raibaud O, Schwartz M.
(
6259122
)
|
EMBO J. 1989;8:981-987
MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcriptional activator.
Richet, E., and O. Raibaud.
|
Gene. 1986;42(2):201-8.
The nucleotide sequence of the malT gene encoding the positive regulator of the Escherichia coli maltose region.
Cole ST, Raibaud O.
(
3015733
)
|
J Mol Biol. 1996;262(1):1-11.
Two amino acid residues from the DNA-binding domain of MalT play a crucial role in transcriptional activation.
Danot O, Vidal-Ingigliardi D, Raibaud O.
(
8809174
)
|
J Bacteriol. 1990;172(4):1846-52.
Characterization of malT mutants that constitutively activate the maltose regulon of Escherichia coli.
Dardonville B, Raibaud O.
(
2180908
)
|
J Mol Biol. 1979;132(3):521-34.
The use of gene fusions to study the expression of malT the positive regulator gene of the maltose regulon.
Debarbouille M, Schwartz M.
(
118263
)
|
Mol Gen Genet. 1980;178(3):589-95.
Mutants which make more malT product, the activator of the maltose regulon in Escherichia coli.
Debarbouille M, Schwartz M.
(
6993855
)
|
Mol Gen Genet. 1982;185(1):88-92.
A DNA sequence containing the control sites for gene malT and for the malPQ operon.
Debarbouille M, Cossart P, Raibaud O.
(
6283313
)
|
Sequences |
Amino acid
FASTA format
|
0001 MLIPSKLSRP VRLDHTVVRE RLLAKLSGAN NFRLALITSP AGYGKTTLIS QWAAGKNDIG WYSLDEGDNQ
0071 QERFASYLIA AVQQATNGHC AICETMAQKR QYASLTSLFA QLFIELAEWH SPLYLVIDDY HLITNPVIHE
0141 SMRFFIRHQP ENLTLVVLSR NLPQLGIANL RVRDQLLEIG SQQLAFTHQE AKQFFDCRLS SPIEAAESSR
0211 ICDDVSGWAT ALQLIALSAR QNTHSAHKSA RRLAGINASH LSDYLVDEVL DNVDLATRHF LLKSAILRSM
0281 NDALITRVTG EENGQMRLEE IERQGLFLQR MDDTGEWFCY HPLFGNFLRQ RCQWELAAEL PEIHRAAAES
0351 WMAQGFPSEA IHHALAAGDA LMLRDILLNH AWSLFNHSEL SLLEESLKAL PWDSLLENPQ LVLLQAWLMQ
0421 SQHRYGEVNT LLARAEHEIK DIREDTMHAE FNALRAQVAI NDGNPDEAER LAKLALEELP PGWFYSRIVA
0491 TSVLGEVLHC KGELTRSLAL MQQTEQMARQ HDVWHYALWS LIQQSEILFA QGFLQTAWET QEKAFQLINE
0561 QHLEQLPMHE FLVRIRAQLL WAWARLDEAE ASARSGIEVL SSYQPQQQLQ CLAMLIQCSL ARGDLDNARS
0631 QLNRLENLLG NGKYHSDWIS NANKVRVIYW QMTGDKAAAA NWLRHTAKPE FANNHFLQGQ WRNIARAQIL
0701 LGEFEPAEIV LEELNENARS LRLMSDLNRN LLLLNQLYWQ AGRKSDAQRV LLDALKLANR TGFISHFVIE
0771 GEAMAQQLRQ LIQLNTLPEL EQHRAQRILR EINQHHRHKF AHFDENFVER LLNHPEVPEL IRTSPLTQRE
0841 WQVLGLIYSG YSNEQIAGEL EVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG V
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 TCGCTTGCAT TAGAAAGGTT TCTGGCCGAC
-070 CTTATAACCA TTAATTACGA AGCGCAAAAA AAATAATATT TCCTCATTTT CCACAGTGAA GTGATTAACT
0001 atgctgattc cgtcaaaact aagtcgtccg gttcgactcg accataccgt ggttcgtgag cgcctgctgg
0071 ctaaactttc cggcgcgaac aacttccggc tggcgctgat cacgagtcct gcgggctacg gaaagaccac
0141 cctcatttcc cagtgggcgg caggcaaaaa cgatatcggc tggtactcgc tggatgaagg tgataaccag
0211 caagagcgtt tcgccagcta tctcattgcc gccgtgcagc aggcaaccaa cggtcactgt gcgatatgtg
0281 agacgatggc gcaaaaacgg caatatgcca gcctgacgtc actcttcgcc cagcttttca ttgagctggc
0351 ggaatggcat agcccacttt atctggtcat cgatgactat catctgatca ctaatccagt gatccacgag
0421 tcaatgcgct tctttattcg ccatcaacca gaaaatctca ccctggtggt gttgtcacgc aaccttccgc
0491 aactgggcat tgccaatctg cgtgttcgtg atcaactgct ggaaattggc agtcagcaac tggcatttac
0561 ccatcaggaa gcgaagcagt tttttgattg ccgtctgtca tcgccgattg aagccgcaga aagcagtcgg
0631 atttgcgatg acgtttccgg ttgggcgacg gcactacagc taatcgccct ctccgcccgg cagaataccc
0701 actcagccca taagtcggca cgccgcctgg cgggaatcaa tgccagccat ctttcggatt atctggtcga
0771 tgaggttttg gataacgtcg atctcgcaac gcgccatttt ctgttgaaaa gcgccatttt gcgctcaatg
0841 aacgatgccc tcatcacccg tgtgaccggc gaagaaaacg ggcaaatgcg cctcgaagag attgagcgtc
0911 aggggctgtt tttacagcgg atggatgata ccggcgagtg gttctgctat cacccgctgt ttggtaactt
0981 cctgcgccag cgctgccagt gggaactggc ggcggagctg ccggaaatcc accgtgccgc cgcagaaagc
1051 tggatggccc agggatttcc cagcgaagca attcatcatg cgctggcggc aggcgatgcg ctgatgctgc
1121 gcgatattct gcttaatcac gcctggagtc tgttcaacca tagcgaactg tcgctgctgg aagagtcgct
1191 taaggccctg ccgtgggaca gcttgctgga aaatccgcag ttggtgttat tgcaggcgtg gctgatgcaa
1261 agccaacatc gctacggcga agttaacacc ctgctagccc gtgctgaaca tgaaatcaag gacatcagag
1331 aagacaccat gcacgcagaa tttaacgctc tgcgcgccca ggtggcgatt aacgatggta atccggatga
1401 agcggaacgg ctggcaaaac tggcactgga agagctgccg ccgggctggt tctatagccg cattgtggca
1471 acctcggtgc tgggtgaagt gctgcactgc aaaggcgaat tgacccgctc actggcgcta atgcagcaaa
1541 ccgaacagat ggcacgccag cacgatgtct ggcactacgc tttgtggagt ttaatccagc aaagtgaaat
1611 tctgtttgcc caagggttcc tgcaaaccgc gtgggaaacg caggaaaaag cattccagct gatcaacgag
1681 cagcatctgg aacagctgcc aatgcatgag tttctggtgc gcattcgtgc gcagctgtta tgggcctggg
1751 cgcggctgga tgaagccgaa gcgtcggcgc gtagcgggat tgaagtcttg tcgtcttatc agccacagca
1821 acagcttcag tgcctggcaa tgttgattca atgctcgctg gcccgtggtg atttagataa cgcccgtagc
1891 cagctgaacc gtctggaaaa cctgctgggg aatggcaaat atcacagcga ctggatctct aacgccaaca
1961 aagtccgggt gatttactgg caaatgaccg gcgataaagc cgccgctgcc aactggttgc gtcatacggc
2031 taaaccagag tttgcgaaca accacttcct gcaaggtcaa tggcgcaaca ttgcccgtgc acaaatcttg
2101 ctgggcgagt ttgaaccggc agaaattgtt ctcgaagaac tcaatgaaaa tgcccggagt ctgcggttga
2171 tgagcgatct caaccgtaac ctgttgctgc ttaatcaact gtactggcag gccggacgta aaagtgacgc
2241 ccagcgcgtg ttgctggacg cattaaaact ggcgaatcgc accggattta tcagccattt tgtcatcgaa
2311 ggcgaagcga tggcgcaaca actgcgtcag ctgattcagc ttaatacgct gccggaactg gaacagcatc
2381 gcgcgcagcg tattctgcga gaaatcaatc aacatcatcg gcataaattc gcccatttcg atgagaattt
2451 cgttgaacgt ctgctaaatc atcctgaagt acctgaactg atccgcacca gcccgctgac gcaacgtgaa
2521 tggcaggtac tggggctgat ctactctggt tacagcaatg agcaaattgc cggagaactg gaagtcgcgg
2591 caaccaccat caaaacgcat atccgcaatc tgtatcagaa actcggcgtg gcccatcgcc aggatgcggt
2661 acaacacgcc cagcaattgc tgaagatgat ggggtacggc gtgtaaGTTT AGCCGGATAA CGCGCCAGAT
2731 CCGGCTTACA TCTCTGCATC ATTCAATGCT CACCCGCGTT ACGCCATCTG TTTCTATCAA ACTAAACCGC
2801 ACCGGC
|