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PEC Original Annotations
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Essentiality
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Class
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non-essential
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References (PMID)
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Escherichia coli and Salmonella, Cellular and Molecular Biology Second Edition. ASM Press. 1996
Neidhart, F.C.
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Deletion
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20
(LD)
,
DE(PLK1608)
,
OCR70,L90-6 (LD 20-1_P/O & 20-2TC)
(D)
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Related gene (W3110 PEC)
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Gene Search
|
Search MG1655 PEC by gene name:
marA
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Related strains
|
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Strains Search
|
Search strains by gene name:
marA
Search strains by all related name:
marA b1531 cfxB ECK1524 inaR JW5249 nfxC norB soxQ
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General information (Go to Linear View: )
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Gene Name
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marA
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Alternative name
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b1531,cfxB,ECK1524,inaR,JW5249,nfxC,norB,soxQ
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Location, Length
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1,617,598 - 1,617,981
(
+
)
;
34.86
min
;
384
(bp) ,
127
(aa)
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Product
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DNA-binding transcriptional dual activator of multiple antibiotic resistance
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Operon Name
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marRAB
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Note
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multiple antibiotic resistance; transcriptional activator of defense systems; GO_component: GO:0005737 - cytoplasm; GO_function: GO:0016563 - transcription activator activity; GO_process: GO:0006350 - transcription; GO_process: GO:0042493 - response to drug; GO_process: GO:0006805 - xenobiotic metabolic process
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Function
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regulator; Drug/analog sensitivity
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Gene Ontology
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GO:0003677
;
DNA binding ( marA )
GO:0003700
;
transcription factor activity ( marA )
GO:0005622
;
intracellular ( marA )
GO:0006350
;
transcription ( marA )
GO:0006355
;
regulation of transcription, DNA-dependent ( marA )
GO:0043565
;
sequence-specific DNA binding ( marA )
GO:0045449
;
regulation of transcription ( marA )
GO:0046677
;
response to antibiotic ( marA )
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PID
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87081928
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EC number
(KEGG Pathway)
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|
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SWISS-PROT
(
Show details
[
2
more]
)
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Entry name(Acc.no)
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MARR_ECOLI
(
P27245
;
P76882; P77582
)
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- Protein name
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Multiple antibiotic resistance protein marR.
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- Synonyms
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- Gene name
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Name=marR; Synonyms=soxQ, cfxB, inaR; OrderedLocusNames=b1530;
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MMBR References
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J Bacteriol. 1994;176:143-148
Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli.
Ariza, R. R., S. P. Cohen, N. Bachhawat, S. B. Levy, and B. Demple.
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J Bacteriol. 1993;175:2888-2894
Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli.
Gambino, L., S. J. Gracheck, and P. F. Miller.
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J Bacteriol. 1983;155(2):541-8.
Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics.
George AM, Levy SB.
(
6307967
)
|
Antimicrob Agents Chemother. 1996;40:1266-1269
Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.
Goldman, J. D., D. G. White, and S. B. Levy.
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J Bacteriol. 1991;173(14):4433-9.
Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli.
Greenberg JT, Chou JH, Monach PA, Demple B.
(
1648558
)
|
J Bacteriol. 1991;173(17):5532-8.
marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli.
Hachler H, Cohen SP, Levy SB.
(
1715857
)
|
J Mol Evol. 1996;42(4):409-13.
Untranslated sequence upstream of MarA in the multiple antibiotic resistance locus of Escherichia coli is related to the effector-binding domain of the XylS transcriptional activator.
Hachler H, Cohen SP, Levy SB.
(
8642609
)
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J Bacteriol. 1995;177:7100-7104
Purification and regulatory properties of MarA protein, a transcriptional activator of Escherichia coli multiple antibiotic and superoxide resistance promoters.
Jair, K. W., R. G. Martin, J. L. Rosner, N. Fujita, A. Ishihama, and R. E. Wolf.
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J Bacteriol. 1996;178:2216-2223
Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli.
Martin, R. G., K. W. Jair, R. E. Wolf, and J. L. Rosner.
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J Bacteriol. 1994;176:6262-6269
Dual regulation of inaA by the multiple antibiotic resistance (mar) and superoxide (soxRS) stress response systems of Escherichia coli.
Rosner, J. L., and J. L. Slonczewski.
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Antimicrob Agents Chemother. 1997;41:2699-2704
Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs.
White, D. G., K. Maneewannakul, E. von Hofe, M. Zillman, W. Eisenberg, A. K. Field, and S. B. Levy.
|
J Bacteriol. 1992;174:1537-1543
pH dependence and gene structure of inaA in Escherichia coli.
White, S., F. E. Tuttle, D. Blankenhorn, D. C. Dosch, and J. L. Slonczewski.
|
J Bacteriol. 1993;175:1484-1492
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli.
Cohen, S. P., H. Hachler, and S. B. Levy.
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J Bacteriol. 1988;170(12):5416-22.
marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli.
Cohen SP, McMurry LM, Levy SB.
(
2848006
)
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| Sequences |
Amino acid
FASTA format
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0001 MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS RKMTEIAQKL
0071 KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRMT NMQGESRFLH PLNHYNS
|
Nucleotide
FASTA format
View sequence out neighbor 100bp
|
-100 CTGCACCAAG AATTAACAAA AAACCTGACG
-070 GCGGACGAAG TGGCAACACT TGAGTATTTG CTTAAGAAAG TCCTGCCGTA AACAAAAAAG AGGTATGACG
0001 atgtccagac gcaatactga cgctattacc attcatagca ttttggactg gatcgaggac aacctggaat
0071 cgccactgtc actggagaaa gtgtcagagc gttcgggtta ctccaaatgg cacctgcaac ggatgtttaa
0141 aaaagaaacc ggtcattcat taggccaata catccgcagc cgtaagatga cggaaatcgc gcaaaagctg
0211 aaggaaagta acgagccgat actctatctg gcagaacgat atggcttcga gtcgcaacaa actctgaccc
0281 gaaccttcaa aaattacttt gatgttccgc cgcataaata ccggatgacc aatatgcagg gcgaatcgcg
0351 ctttttacat ccattaaatc attacaacag ctagTTGAAA ACGTGACAAC GTCACTGAGG CAATCATGAA
0421 ACCACTTTCA TCCGCAATAG CAGCTGCGCT TATTCTCTTT TCCGCGCAGG GCGTTGCGGA ACAA
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