Mutants (Isolated)


Allele Nametm917
Sequence NameY48E1B.13
CGC Namecsp-1
Worm BaseAllele Name tm917
CGC Name csp-1
Sequence Y48E1B.13
Phenotypehomozygous viable. Dr. R.H. Horvitz: No extra cells in anterior pharynx. Dr. S. Shaham: no defects in somatic cell death.
Mutation site76885/76886-77634/77635 (749 bp deletion)
Putative gene structurejoin(76378..76614, 77078..77206, 77454..77803, 78165..78306, 78570..78708, 79626..79879, 79924..80131, 80291..80596, 80631..80692, 80817..80918)
Map position18.6
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Denning DP, Hatch V, Horvitz HR.
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
PLoS Genet 2013 9(3) e1003341 
[ PubMed ID = 23505386 ] [ RRC reference ]

Chen L, McCloskey T, Joshi PM, Rothman JH.
ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans.
Curr Biol 2008 18(14) 1025-33 
[ PubMed ID = 18635357 ] [ RRC reference ]

Abraham MC, Lu Y, Shaham S.
A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans.
Dev Cell 2007 12(1) 73-86 
[ PubMed ID = 17199042 ] [ RRC reference ]