Mutants (Isolated)


Allele Nametm812
Sequence NameF28H6.1a
CGC Nameakt-2
Worm BaseAllele Name tm812
CGC Name akt-2
Sequence F28H6.1a
PhenotypeHomozygous viable. Dr. K. Ashrafi: substantially increased fat (nile red staining). PLoS Biol, 7, e1000060, 0604 (2009). Dr. W.B. Derry: mild hypersensitivity to ionizing radiation induced germ cell apoptosis.
Mutation site[F28H6]37780/37781-TA-[R03E1]430/431 (522 bp deletion + 2 bp insertion)
Putative gene structurejoin(35289..35383, 35587..35695, 36588..36788, 36832..36951, 37176..37373, 37845..37975, Z92837:104..164, Z92837:275..403, Z92837:451..813, Z92837:1091..1270)
Map position16.55
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ.
Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation.
Aging Cell 2013 12(5) 932-40 
[ PubMed ID = 23786484 ] [ RRC reference ]

Jones KT, Greer ER, Pearce D, Ashrafi K.
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.
PLoS Biol. 2009 7(3) e60 
[ PubMed ID = 19260765 ] [ RRC reference ]

Alan JK, Struckhoff EC, Lundquist EA.
Multiple cytoskeletal pathways and PI3K signaling mediate CDC-42-induced neuronal protrusion in C. elegans.
Small GTPases 2013 4(4) 208-20 
[ PubMed ID = 24149939 ] [ RRC reference ]