Mutants (Isolated)


Allele Nametm548
Sequence NameF25D7.3
CGC Nameblmp-1
Worm BaseAllele Name tm548
CGC Name blmp-1
Sequence F25D7.3
Phenotypehomozygous viable. Dr. K. Ashrafi: healthy, fertile, has a small body size and altered fat content at adult stage. Dr. R. Plasterk: Dpy appearance. Dr. R.H. Horvitz: not synMuv with class A or B mutations and not a synMuv suppressor. Dr. M. Hengartner: very slight increase in germ cell apoptosis. Dr. W. Vermeulen: Gro, Dpy, Pvl. Dr. Y-C. Wu: slightly Unc, mild Dpy, abnormal gonad morphology. Dr. O. Blacque: Dyf (+), wild-type localization of ODR-10 to AWB cilium. Dr. C. Yang: no obvious cell death defects. Dr. J. Kaplan: Sma, abnormal gonad.
Mutation site19893/19894-20703/20704 (810 bp deletion)
Putative gene structurejoin(18588..18765,19099..19193,19455..20322,20833..21179, 21562..21656, 21707..22175, 22591..22638, 22722..23075)
Map position4.99
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Nelson MD, Zhou E, Kiontke K, Fradin H, Maldonado G, Martin D, Shah K, Fitch DH.
A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.
PLoS Genet 2011 7(3) e1002010 
[ PubMed ID = 21408209 ] [ RRC reference ]

Horn M, Geisen C, Cermak L, Becker B, Nakamura S, Klein C, Pagano M, Antebi A.
DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.
Dev Cell 2014 28(6) 697-710 
[ PubMed ID = 24613396 ] [ RRC reference ]

Padmanabha D, Padilla PA, You YJ, Baker KD.
A HIF-independent mediator of transcriptional responses to oxygen deprivation in Caenorhabditis elegans.
Genetics 2015 199(3) 739-48 
[ PubMed ID = 25552276 ] [ RRC reference ]

Huang TF, Cho CY, Cheng YT, Huang JW, Wu YZ, Yeh AY, Nishiwaki K, Chang SC, Wu YC.
BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
PLoS Genet 2014 10(6) e1004428 
[ PubMed ID = 24968003 ] [ RRC reference ]