Home > Mutants (Isolated) > tm4439

Mutants (Isolated)

Allele Name		tm4439
Balance		Not Required
OutCross		Not Accepted
Sequence Name		C27H5.3
Gene Name		fust-1
Worm Base	Allele Name	tm4439
	Gene Name	fust-1
	Sequence	C27H5.3
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable.
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		1730/1731-1970/1971 (240 bp deletion)
Chromosome		II
Putative gene structure		join(1310..1313, 1514..1620, 1746..2031, 2080..2137, 2702..2739, 2947..3085, 3131..3740, 3789..3893)
Map position		0.5
Balancer
Map position of balancer
Sequence of primers		IntFwd:CGGGCGTTGCCATTTCTGTT,ExtFwd:GTGGGAGCTCCCGAATACAA,IntRev:GCTTCATTGCGGACACTGAC,ExtRev:GCCATAGCCCTACAAATCGA
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Pir GJ, Buddenkotte J, Alam MA, Own A, Eck RJ, Kraemer BC, Mandelkow E, Steinhoff M. TDP-43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models. FEBS J 2026 293(2) 348-384  [ PubMed ID = 40891506 ] [ RRC reference ] Wong CH, Rahat A, Chang HC. Fused in sarcoma regulates glutamate signaling and oxidative stress response. Free Radic Biol Med 2024 210 172-182  [ PubMed ID = 38007141 ] [ RRC reference ] Eck RJ, Stair JG, Kraemer BC, Liachko NF. Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Front Neurosci 2023 17 1300705  [ PubMed ID = 38239833 ] [ RRC reference ] Cao D. An autoregulation loop in fust-1 for circular RNA regulation in Caenorhabditis elegans. Genetics 2021 219(3)   [ PubMed ID = 34740247 ] [ RRC reference ] Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell 2018 69(5) 787-801.e8  [ PubMed ID = 29499134 ] [ RRC reference ] Therrien M, Rouleau GA, Dion PA, Parker JA. FET proteins regulate lifespan and neuronal integrity. Sci Rep 2016 6 25159  [ PubMed ID = 27117089 ] [ RRC reference ] Tauffenberger A, Chitramuthu BP, Bateman A, Bennett HP, Parker JA. Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models. Hum Mol Genet 2013 22(4) 782-94  [ PubMed ID = 23172908 ] [ RRC reference ] Zhang T, Hwang HY, Hao H, Talbot C Jr, Wang J. Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span. J Biol Chem 2012 287(11) 8371-82  [ PubMed ID = 22232551 ] [ RRC reference ]