Mutants (Isolated)

tm4248

Allele Name

tm4248

Sequence Name

K02F3.4

CGC Name

zip-2

Worm Base

Allele Name

tm4248

CGC Name

zip-2

Sequence

K02F3.4

Phenotype

homozygous viable. Dr. J. Kaplan: non-Egl, non-Dpy, non-Sma.

Mutation site

12299/12300-12521/12522 (222 bp deletion)

Chromosome

III

Putative gene structure

join(11760..11768, 11821..12136, 12193..12513, 12628..12908)

Map position

-25.78

Balancer

Map position of balancer

Sequence of primers

ExtRev:TAGTCCTCGACTTGAGTCTC,IntRev:TTCGCTTCTCTAGACGCTCT,ExtFwd:CAGTGTTGCTTCATGGACGA,IntFwd:CCAAGTATGGAGCCGGTTAG

Distributed lab

Depositor

Dr. S. Mitani

References

Please submit your publication

Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel ER.
The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
Cell Rep 2016 14(7) 1581-1589
[ PubMed ID = 26876169 ] [ RRC reference ]

McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM.
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.
BMC Biol 2016 14(1) 105
[ PubMed ID = 27927200 ] [ RRC reference ]

Tjahjono E, Kirienko NV.
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa.
PLoS Genet 2017 13(6) e1006876
[ PubMed ID = 28662060 ] [ RRC reference ]

McEwan DL, Kirienko NV, Ausubel FM.
Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans.
Cell Host Microbe 2012 11(4) 364-74
[ PubMed ID = 22520464 ] [ RRC reference ]

Dunbar TL, Yan Z, Balla KM, Smelkinson MG, Troemel ER.
C. elegans detects pathogen-induced translational inhibition to activate immune signaling.
Cell Host Microbe 2012 11(4) 375-86
[ PubMed ID = 22520465 ] [ RRC reference ]

Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
Nature 2014 516(7531) 414-7
[ PubMed ID = 25274306 ] [ RRC reference ]

Kirienko NV, Ausubel FM, Ruvkun G.
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.
Proc Natl Acad Sci U S A 2015 112(6) 1821-6
[ PubMed ID = 25624506 ] [ RRC reference ]