Mutants (Isolated)

tm376

Allele Name

tm376

Sequence Name

C14F5.1

CGC Name

dct-1

Worm Base

Allele Name

tm376

CGC Name

dct-1

Sequence

C14F5.1

Phenotype

homozygous viable

Mutation site

23548/23549-24460/24461 (912 bp deletion)

Chromosome

Putative gene structure

join(24815..24977, 25160..25415, 25847..26017, 26068..26110)

Map position

-0.84

Balancer

Map position of balancer

Sequence of primers

ExtFwd:ACAGAGAGCGTCTGTGTTTG,IntFwd:TTCGCCGCAAGTTTATTGGC,IntRev:TCAAGGGAGATCGAGTGTAC,ExtRev:ATGATTCCTGTCGGATGCGC

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Aspernig H, Heimbucher T, Qi W, Gangurde D, Curic S, Yan Y, Donner von Gromoff E, Baumeister R, Thien A.
Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans.
Cell Rep 2019 29(6) 1399-1409.e5
[ PubMed ID = 31693882 ] [ RRC reference ]

Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B, Lautrup S, Hasan-Olive MM, Caponio D, Dan X, Rocktäschel P, Croteau DL, Akbari M, Greig NH, Fladby T, Nilsen H, Cader MZ, Mattson MP, Tavernarakis N, Bohr VA.
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
Nat Neurosci 2019 22(3) 401-412
[ PubMed ID = 30742114 ] [ RRC reference ]

Palikaras K, Lionaki E, Tavernarakis N.
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
Nature 2015 521(7553) 525-8
[ PubMed ID = 25896323 ] [ RRC reference ]

Schiavi A, Maglioni S, Palikaras K, Shaik A, Strappazzon F, Brinkmann V, Torgovnick A, Castelein N, De Henau S, Braeckman BP, Cecconi F, Tavernarakis N, Ventura N.
Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.
Curr Biol 2015 25(14) 1810-22
[ PubMed ID = 26144971 ] [ RRC reference ]