Mutants (Isolated)

tm3056

Allele Nametm3056
Sequence NameY54G2A.25
CGC Namelad-2
Worm BaseAllele Name tm3056
CGC Name lad-2
Sequence Y54G2A.25
Phenotypehomozygous viable. Dr. L. Chen: J. Cell Biol. 180, 233 (2008).
Mutation site223647/223648-224711/224712 (1064 bp deletion)
ChromosomeIV
Putative gene structurecomplement(join(214208..214285, 215029..215279, 215955..216146, 216197..216352, 216563..216691, 216996..217107, 217364..217554, 217604..217727, 217772..218140, 218590..218723, 218771..218889, 218945..219104, 219519..219639, 223240..223400, 223454..223741, 224310..224594, 224645..224847, 226089..226209, 226993..227063, 227110..227226, 227951..228065, 228111..228177))
Map position-6.72
Balancer
Map position of balancer
Sequence of primersExtFwd:ATCCCAACGGATTGCTAGCA,IntFwd:GCTAGCATTGCATTGGTAGA,IntRev:AACTATCCGGAGCCGACACA,ExtRev:CCTAGACGATTCCTCCGTAA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Chen L, Zhou S.
"CRASH"ing with the worm: insights into L1CAM functions and mechanisms.
Dev. Dyn. 2010 239(5) 1490-501 
[ PubMed ID = 20225255 ] [ RRC reference ]

Wang X, Zhang W, Cheever T, Schwarz V, Opperman K, Hutter H, Koepp D, Chen L.
The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance.
J. Cell Biol. 2008 180(1) 233-46 
[ PubMed ID = 18195110 ] [ RRC reference ]

Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z, Bülow HE.
Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
Cell 2013 155(2) 308-20 
[ PubMed ID = 24120132 ] [ RRC reference ]