Mutants (Isolated)


Allele Nametm299
Sequence NameT15H9.3
CGC Namehlh-6
Worm BaseAllele Name tm299
CGC Name hlh-6
Sequence T15H9.3
Phenotypelethal or sterile. Dr. J. Gaudet: PLoS Genetics 4, e1000222 (2008)
Mutation site11224/11225-11819/11820 (595 bp deletion)
Putative gene structurecomplement(join(10595..10787, 11095..11193, 11238..11541, 11683..11893))
Map position1.51
BalancerNot Yet Balanced
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Ghai V, Smit RB, Gaudet J.
Transcriptional regulation of HLH-6-independent and subtype-specific genes expressed in the Caenorhabditis elegans pharyngeal glands.
Mech Dev 2012 129(9-12) 284-97 
[ PubMed ID = 22759833 ] [ RRC reference ]

Raharjo WH, Ghai V, Dineen A, Bastiani M, Gaudet J.
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
Genetics 2011 189(3) 885-97 
[ PubMed ID = 21868609 ] [ RRC reference ]

Gruner M, Grubbs J, McDonagh A, Valdes D, Winbush A, van der Linden AM.
Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors.
PLoS Genet 2016 12(8) e1006237 
[ PubMed ID = 27487365 ] [ RRC reference ]

Smit RB, Schnabel R, Gaudet J.
The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.
PLoS Genet 2008 4(10) e1000222 
[ PubMed ID = 18927627 ] [ RRC reference ]

Raharjo I, Gaudet J.
Gland-specific expression of C. elegans hlh-6 requires the combinatorial action of three distinct promoter elements.
Dev Biol 2007 302(1) 295-308 
[ PubMed ID = 17049341 ] [ RRC reference ]

Luo S, Horvitz HR.
The CDK8 Complex and Proneural Proteins Together Drive Neurogenesis from a Mesodermal Lineage.
Curr Biol 2017 27(5) 661-672 
[ PubMed ID = 28238659 ] [ RRC reference ]

Reece-Hoyes JS, Deplancke B, Barrasa MI, Hatzold J, Smit RB, Arda HE, Pope PA, Gaudet J, Conradt B, Walhout AJ.
The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors.
Nucleic Acids Res 2009 37(11) 3689-98 
[ PubMed ID = 19372275 ] [ RRC reference ]