Mutants (Isolated)


Allele Nametm2966
Sequence NameY48B6A.11
CGC Namejmjd-2
Worm BaseAllele Name tm2966
CGC Name jmjd-2
Sequence Y48B6A.11
Phenotypehomozygous viable. Dr. M. Han: normal vulval phenotype.
Mutation site89670/89671-TNCACACACACCTTAATC-90343/90344 (673 bp deletion + 18 bp insertion)
Putative gene structurecomplement(join(86445..87456, 88264..88408, 89561..90651, 91314..91538, 93031..93242))
Map position22.9
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
Greer EL, Becker B, Latza C, Antebi A, Shi Y.
Mutation of C. elegans demethylase spr-5 extends transgenerational longevity.
Cell Res 2016 26(2) 229-38 
[ PubMed ID = 26691751 ] [ RRC reference ]

Mutlu B, Chen HM, Gutnik S, Hall DH, Keppler-Ross S, Mango SE.
Distinct functions and temporal regulation of methylated histone H3 during early embryogenesis.
Development 2019 146(19)  
[ PubMed ID = 31540912 ] [ RRC reference ]

Kreher J, Takasaki T, Cockrum C, Sidoli S, Garcia BA, Jensen ON, Strome S.
Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans.
Genetics 2018 210(3) 969-982 
[ PubMed ID = 30217796 ] [ RRC reference ]

Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.
Mol Cell 2010 40(5) 736-48 
[ PubMed ID = 21145482 ] [ RRC reference ]

Zheng C, Karimzadegan S, Chiang V, Chalfie M.
Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans.
PLoS Genet 2013 9(12) e1004017 
[ PubMed ID = 24348272 ] [ RRC reference ]

Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizábal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiácovo MP, Shi Y.
A histone methylation network regulates transgenerational epigenetic memory in C. elegans.
Cell Rep 2014 7(1) 113-26 
[ PubMed ID = 24685137 ] [ RRC reference ]