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Mutants (Isolated)

Allele Name		tm2572
Allele Type		Normal
Sequence Name		W03A3.2
Gene Name		polq-1
Worm Base	Allele Name	tm2572
	Gene Name	polq-1
	Sequence	W03A3.2
Phenotype Information from the receiver is posted in the form of a "researcher : phenotype"		homozygous viable
Mutation site Please see gene structure to locate the deletion in relation to exon(s)		13964/13965-ATCTTTCGGGTCGTTTGCCAACTGCTCAACCTCTGCACAGTCACAAGTGACACGCACAGGGCCGTGGTGCGCAGAGGCACGGCGATGATCCAGCTGCAGGTTCACCTACAGCTACCTTGTTACGACTTTTACCCGGTTCAAACCAATGCGATAA-14612/14613 (648 bp deletion + 154 bp insertion)
Chromosome		III
Putative gene structure		complement(join(3560..3849, 4228..4437, 4489..4822, 4944..5612, 5668..5825, 6090..6318, 6365..6468, 6695..7452, 8474..8578, 9009..9147, 9281..9350, 9541..9774, 9829..9906, 10014..10397, 10819..10952, 13612..13734, 14205..14847, 14898..[R12B2]568, 621..744, 795..863))
Map position		-1.45
Balancer
Map position of balancer
Sequence of primers		ExtFwd:GGTGCACCATGATAGGTATT,IntFwd:TTACGACAGTGACACCACAA,ExtRev:TGTACCATCGAAAAAGCAGC,IntRev:CGATTCGTCTCGTGGTGCAC
Distributed lab
Depositor		Dr. S. Mitani/NBRP
References		Please submit your publication Bae W, Park JH, Lee MH, Park HW, Koo HS. Hypersensitivity to DNA double-strand breaks associated with PARG deficiency is suppressed by exo-1 and polq-1 mutations in Caenorhabditis elegans. FEBS J 2020 287(6) 1101-1115  [ PubMed ID = 31593615 ] [ RRC reference ] Papaluca A, Wagner JR, Saragovi HU, Ramotar D. UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. Sci Rep 2018 8(1) 6860  [ PubMed ID = 29717169 ] [ RRC reference ] Asagoshi K, Lehmann W, Braithwaite EK, Santana-Santos L, Prasad R, Freedman JH, Van Houten B, Wilson SH. Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Res 2012 40(2) 670-81  [ PubMed ID = 21917855 ] [ RRC reference ] Koole W, van Schendel R, Karambelas AE, van Heteren JT, Okihara KL, Tijsterman M. A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites. Nat Commun 2014 5 3216  [ PubMed ID = 24496117 ] [ RRC reference ]