Mutants (Isolated)


Allele Nametm2256
Sequence NameT05D4.4
CGC Nameosm-7
Worm BaseAllele Name tm2256
CGC Name osm-7
Sequence T05D4.4
Phenotypehomozygous viable. Dr. A. Hart: Plos Biol. 6, e196 (2008).
Mutation site23507/23508-TC-23638/23639 (131 bp deletion + 2 bp insertion)
Putative gene structurejoin(22064..22334, 22883..23055, 23269..23440, 23559..23698, 23854..23942, 24048..24159, 24220..24270, 24321..24533, 24867..25033, 25393..25500, 25546..25648, 26043..26538)
Map position21.27
Map position of balancer
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Bennett HL, Khoruzhik Y, Hayden D, Huang H, Sanders J, Walsh MB, Biron D, Hart AC.
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.
BMC Neurosci 2018 19(1) 10 
[ PubMed ID = 29523076 ] [ RRC reference ]

Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, SorkaƧ A, Huang H, Dimitriadi M, Sinclair DA, Hart AC.
C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.
Mech Ageing Dev 2016 154 30-42 
[ PubMed ID = 26854551 ] [ RRC reference ]

SorkaƧ A, DiIorio MA, O'Hern PJ, Baskoylu SN, Graham HK, Hart AC.
LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction.
G3 (Bethesda) 2018 8(8) 2825-2832 
[ PubMed ID = 29950427 ] [ RRC reference ]

Singh K, Chao MY, Somers GA, Komatsu H, Corkins ME, Larkins-Ford J, Tucey T, Dionne HM, Walsh MB, Beaumont EK, Hart DP, Lockery SR, Hart AC.
C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence.
Curr Biol 2011 21(10) 825-34 
[ PubMed ID = 21549604 ] [ RRC reference ]

Dresen A, Finkbeiner S, Dottermusch M, Beume JS, Li Y, Walz G, Neumann-Haefelin E.
Caenorhabditis elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response.
Dev Biol 2015 400(1) 118-31 
[ PubMed ID = 25637691 ] [ RRC reference ]

Komatsu H, Chao MY, Larkins-Ford J, Corkins ME, Somers GA, Tucey T, Dionne HM, White JQ, Wani K, Boxem M, Hart AC.
OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
PLoS Biol 2008 6(8) e196 
[ PubMed ID = 18700817 ] [ RRC reference ]