Mutants (Isolated)

tm2051

Allele Nametm2051
Sequence NameF41G3.12
CGC Nameagr-1
Worm BaseAllele Name tm2051
CGC Name agr-1
Sequence F41G3.12
Phenotypehomozygous viable. Dr. Y-C. Wu: no hyperactive no locomotion defect.
Mutation site22164/22165-22587/22588 (423 bp deletion)
ChromosomeII
Putative gene structurecomplement(join(20958..21219, 21763..21943, 22271..22329, 22449..22515, 27393..27667, 27717..27834, 27880..28008, 28055..28256, 28307..28363, 28939..29031, 29082..29173, 29224..29329, 29372..29437, 29730..29961, 30025..30172, 30218..30402, 30442..30640, 30786..30894, 30944..31062, 31198..31425, 31473..31685, 31732..31822, 31872..32082, 32129..32258, 32314..32556, 34249..34458, 34513..34567, 34614..34706, 34750..34842, 34889..35074))
Map position0.09
Balancer
Map position of balancer
Sequence of primersExtFwd:CACGTCTCCTGGTGAAGCGA,IntFwd:TGGTGAAGCGACGACGTGAA,ExtRev:GCTGTGAGACTAACTTGGGA,IntRev:AGCTCTTCTCTGCCTCCCAT
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Hrus A, Lau G, Hutter H, Schenk S, Ferralli J, Brown-Luedi M, Chiquet-Ehrismann R, Canevascini S.
C. elegans agrin is expressed in pharynx, IL1 neurons and distal tip cells and does not genetically interact with genes involved in synaptogenesis or muscle function.
PLoS ONE 2007 2(8) e731 
[ PubMed ID = 17710131 ] [ RRC reference ]

Blanchette CR, Perrat PN, Thackeray A, Bénard CY.
Glypican Is a Modulator of Netrin-Mediated Axon Guidance.
PLoS Biol. 2015 13(7) e1002183 
[ PubMed ID = 26148345 ] [ RRC reference ]

Dejima K, Kang S, Mitani S, Cosman PC, Chisholm AD.
Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.
Development 2014 141(22) 4354-65 
[ PubMed ID = 25344071 ] [ RRC reference ]

Attreed M, Desbois M, van Kuppevelt TH, Bülow HE.
Direct visualization of specifically modified extracellular glycans in living animals.
Nat. Methods 2012 9(5) 477-9 
[ PubMed ID = 22466794 ] [ RRC reference ]