Mutants (Isolated)

tm1996

Allele Nametm1996
Sequence NameT07E3.6
CGC Namepdf-1
Worm BaseAllele Name tm1996
CGC Name pdf-1
Sequence T07E3.6
Phenotypehomozygous viable. Dr. S. Husson: J. Biol. Chem. 283, 15241 (2008).
Mutation site14212/14213-14800/14801 (588 bp deletion)
ChromosomeIII
Putative gene structurecomplement(join(12261..12333, 13137..13234, 14284..14655))
Map position-0.9
Balancer
Map position of balancer
Sequence of primersExtFwd:CCGTGGAGGTACCAGGTTAA,IntFwd:CCATTCCGATGAGTCCGTTG,ExtRev:TCAAGGTCTCGCCTCTAGGA,IntRev:GAATACGATCCGGTGGCAGA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Janssen T, Husson SJ, Lindemans M, Mertens I, Rademakers S, Ver Donck K, Geysen J, Jansen G, Schoofs L.
Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.
J. Biol. Chem. 2008 283(22) 15241-9 
[ PubMed ID = 18390545 ] [ RRC reference ]

Choi S, Taylor KP, Chatzigeorgiou M, Hu Z, Schafer WR, Kaplan JM.
Sensory Neurons Arouse C. elegans Locomotion via Both Glutamate and Neuropeptide Release.
PLoS Genet. 2015 11(7) e1005359 
[ PubMed ID = 26154367 ] [ RRC reference ]

Sammut M, Cook SJ, Nguyen KCQ, Felton T, Hall DH, Emmons SW, Poole RJ, Barrios A.
Glia-derived neurons are required for sex-specific learning in C. elegans.
Nature 2015 526(7573) 385-390 
[ PubMed ID = 26469050 ] [ RRC reference ]

Temmerman L, Bogaerts A, Meelkop E, Cardoen D, Boerjan B, Janssen T, Schoofs L.
A proteomic approach to neuropeptide function elucidation.
Peptides 2012 34(1) 3-9 
[ PubMed ID = 21920396 ] [ RRC reference ]

Hilbert ZA, Kim DH.
PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
Elife 2018 7  
[ PubMed ID = 30024377 ] [ RRC reference ]

Herrero A, Romanowski A, Meelkop E, Caldart CS, Schoofs L, Golombek DA.
Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans.
Genes Brain Behav. 2015 14(6) 493-501 
[ PubMed ID = 26113231 ] [ RRC reference ]

Choi S, Chatzigeorgiou M, Taylor KP, Schafer WR, Kaplan JM.
Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.
Neuron 2013 78(5) 869-80 
[ PubMed ID = 23764289 ] [ RRC reference ]

Barrios A, Ghosh R, Fang C, Emmons SW, Barr MM.
PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.
Nat. Neurosci. 2012 15(12) 1675-82 
[ PubMed ID = 23143519 ] [ RRC reference ]

Janssen T, Husson SJ, Meelkop E, Temmerman L, Lindemans M, Verstraelen K, Rademakers S, Mertens I, Nitabach M, Jansen G, Schoofs L.
Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans.
J. Neurochem. 2009 111(1) 228-41 
[ PubMed ID = 19686386 ] [ RRC reference ]

Kniazeva M, Zhu H, Sewell AK, Han M.
A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans.
Dev. Cell 2015 33(3) 260-71 
[ PubMed ID = 25892013 ] [ RRC reference ]

Frooninckx L, Van Rompay L, Temmerman L, Van Sinay E, Beets I, Janssen T, Husson SJ, Schoofs L.
Neuropeptide GPCRs in C. elegans.
Front Endocrinol (Lausanne) 2012 3 167 
[ PubMed ID = 23267347 ] [ RRC reference ]

Meelkop E, Temmerman L, Janssen T, Suetens N, Beets I, Van Rompay L, Shanmugam N, Husson SJ, Schoofs L.
PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.
Mol. Cell. Endocrinol. 2012 361(1-2) 232-40 
[ PubMed ID = 22579613 ] [ RRC reference ]