Mutants (Isolated)

tm1919

Allele Name

tm1919

Sequence Name

K02G10.7

CGC Name

aqp-8

Worm Base

Allele Name

tm1919

CGC Name

aqp-8

Sequence

K02G10.7

Phenotype

homozygous viable. Dr. J-C. Martinou: not hypersensitive nor hyperresistant to anoxia. Dr. C. Kenyon: normal lifespan. Dr. D.L. Baillie: resistant to osmotic stress.

Mutation site

30855/30856-TAT-31340/31341 (485 bp deletion + 3 bp insertion)

Chromosome

Putative gene structure

complement(join(29807..30103, 30675..30793, 31154..31412, 31461..31562))

Map position

-6.87

Balancer

Map position of balancer

Sequence of primers

ExtRev:TGTAACTTGAGCACCCCTAA,IntRev:CATACTGGAATTGCGAGTCA,ExtFwd:CCACTACTGTCACTATACTC,IntFwd:CCTTTGGCTGGTTGAATGTC

Distributed lab

Depositor

Dr. S. Mitani/NBRP

References

Please submit your publication

Mah AK, Armstrong KR, Chew DS, Chu JS, Tu DK, Johnsen RC, Chen N, Chamberlin HM, Baillie DL.
Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6.
J. Biol. Chem. 2007 282(38) 28074-86
[ PubMed ID = 17660295 ] [ RRC reference ]

Igual Gil C, Jarius M, von Kries JP, Rohlfing AK.
Neuronal Chemosensation and Osmotic Stress Response Converge in the Regulation of aqp-8 in C. elegans.
Front Physiol 2017 8 380
[ PubMed ID = 28649202 ] [ RRC reference ]

Khan LA, Zhang H, Abraham N, Sun L, Fleming JT, Buechner M, Hall DH, Gobel V.
Intracellular lumen extension requires ERM-1-dependent apical membrane expansion and AQP-8-mediated flux.
Nat. Cell Biol. 2013 15(2) 143-56
[ PubMed ID = 23334498 ] [ RRC reference ]