Mutants (Isolated)

tm1652

Allele Nametm1652
Sequence NameZK455.3
CGC Namenpr-9
Worm BaseAllele Name tm1652
CGC Name npr-9
Sequence ZK455.3
Phenotypehomozygous viable. Dr. L. Avery: feeding and satiety behavior normal. Dr. C. Bargmann: viable, fertile, less exploratory on food. Dr. I.D. Chin-Sang: PNAS 105, 1339 (2008).
Mutation site10460/10461-CA-10778/10779 (318 bp deletion + 2 bp insertion)
ChromosomeX
Putative gene structurejoin(8651..8705, 9843..10153, 10224..10379, 10444..10551, 10604..10744, 10791..10856, 11336..11555, 11609..11850, 12097..12132)
Map position3.68
Balancer
Map position of balancer
Sequence of primersExtFwd:CGGACGGTTTCTAAGCGATA,IntFwd:CATAACTCATCGGGCCAACT,ExtRev:CCTTCCCGGAAACTCTGCGA,IntRev:GACACGAATTGGTGTAGGCA
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Bendena WG, Boudreau JR, Papanicolaou T, Maltby M, Tobe SS, Chin-Sang ID.
A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues.
Proc. Natl. Acad. Sci. U.S.A. 2008 105(4) 1339-42 
[ PubMed ID = 18216257 ] [ RRC reference ]

Campbell JC, Chin-Sang ID, Bendena WG.
A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay.
J Vis Exp 2017 (125)  
[ PubMed ID = 28784963 ] [ RRC reference ]

Yu Y, Zhi L, Wu Q, Jing L, Wang D.
NPR-9 regulates the innate immune response in Caenorhabditis elegans by antagonizing the activity of AIB interneurons.
Cell. Mol. Immunol. 2018 15(1) 27-37 
[ PubMed ID = 27133473 ] [ RRC reference ]

Campbell JC, Polan-Couillard LF, Chin-Sang ID, Bendena WG.
NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegans.
PLoS Genet. 2016 12(5) e1006050 
[ PubMed ID = 27223098 ] [ RRC reference ]

Luo J, Xu Z, Tan Z, Zhang Z, Ma L.
Neuropeptide receptors NPR-1 and NPR-2 regulate Caenorhabditis elegans avoidance response to the plant stress hormone methyl salicylate.
Genetics 2015 199(2) 523-31 
[ PubMed ID = 25527285 ] [ RRC reference ]

Harris G, Shen Y, Ha H, Donato A, Wallis S, Zhang X, Zhang Y.
Dissecting the signaling mechanisms underlying recognition and preference of food odors.
J. Neurosci. 2014 34(28) 9389-403 
[ PubMed ID = 25009271 ] [ RRC reference ]

Harris G, Mills H, Wragg R, Hapiak V, Castelletto M, Korchnak A, Komuniecki RW.
The monoaminergic modulation of sensory-mediated aversive responses in Caenorhabditis elegans requires glutamatergic/peptidergic cotransmission.
J. Neurosci. 2010 30(23) 7889-99 
[ PubMed ID = 20534837 ] [ RRC reference ]

Hapiak V, Summers P, Ortega A, Law WJ, Stein A, Komuniecki R.
Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.
J. Neurosci. 2013 33(35) 14107-16 
[ PubMed ID = 23986246 ] [ RRC reference ]

Yemini E, Jucikas T, Grundy LJ, Brown AE, Schafer WR.
A database of Caenorhabditis elegans behavioral phenotypes.
Nat. Methods 2013 10(9) 877-9 
[ PubMed ID = 23852451 ] [ RRC reference ]