Mutants (Isolated)

tm1563

Allele Name

tm1563

Allele Type

Normal

Sequence Name

K02H8.1

Gene Name

mbl-1

Worm Base

Allele Name

tm1563

Gene Name

mbl-1

Sequence

K02H8.1

Phenotype

Homozygous viable

Mutation site

22806/22807-23319/23320 (513 bp deletion)

Chromosome

Putative gene structure

join(23114..23233, 24072..24200, 26162..26326, 28253..28306, 28356..28580, 29583..29744)

Map position

24.07

Balancer

Map position of balancer

Sequence of primers

ExtRev:GGGGCATCGAAATTTGCCAT,IntFwd:ACTGGTTTTCAATCAGGCCA,IntRev:AAGTAGGTCGTACAGCACTA,ExtFwd:TCACAGCAATCATCCCGATG

Distributed lab

Depositor

Dr. S. Mitani

References

Please submit your publication

Verbeeren J, Teixeira J, Garcia SMDA.
The Muscleblind-like protein MBL-1 regulates microRNA expression in Caenorhabditis elegans through an evolutionarily conserved autoregulatory mechanism.
PLoS Genet 2023 19(12) e1011109
[ PubMed ID = 38134228 ] [ RRC reference ]

Puri D, Sharma S, Samaddar S, Ravivarma S, Banerjee S, Ghosh-Roy A.
Muscleblind-1 interacts with tubulin mRNAs to regulate the microtubule cytoskeleton in C. elegans mechanosensory neurons.
PLoS Genet 2023 19(8) e1010885
[ PubMed ID = 37603562 ] [ RRC reference ]

Matilainen O, Ribeiro ARS, Verbeeren J, Cetinbas M, Sood H, Sadreyev RI, Garcia SMDA.
Loss of muscleblind splicing factor shortens Caenorhabditis elegans lifespan by reducing the activity of p38 MAPK/PMK-1 and transcription factors ATF-7 and Nrf/SKN-1.
Genetics 2021 219(2)
[ PubMed ID = 34849877 ] [ RRC reference ]

Spilker KA, Wang GJ, Tugizova MS, Shen K.
Caenorhabditis elegans Muscleblind homolog mbl-1 functions in neurons to regulate synapse formation.
Neural Dev 2012 7 7
[ PubMed ID = 22314215 ] [ RRC reference ]

Sasagawa N, Ohno E, Kino Y, Watanabe Y, Ishiura S.
Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins.
J Neurosci Res 2009 87(5) 1090-7
[ PubMed ID = 19021294 ] [ RRC reference ]