Mutants (Isolated)


Allele Nametm1183
Sequence NameF56A3.5
CGC Namebro-1
Worm BaseAllele Name tm1183
CGC Name bro-1
Sequence F56A3.5
Phenotypehomozygous viable
Mutation site16215/16216-16981/16982 (766 bp deletion)
Putative gene structurejoin(15956..16120, 16553..16618, 17360..17587)
Map position-0.3
Map position of balancer
Distributed lab
DepositorDr. S. Mitani
References Please submit your publication
van der Horst SEM, Cravo J, Woollard A, Teapal J, van den Heuvel S.
C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells.
Development 2019 146(22)  
[ PubMed ID = 31740621 ] [ RRC reference ]

Robinson SB, Refai O, Hardaway JA, Sturgeon S, Popay T, Bermingham DP, Freeman P, Wright J, Blakely RD.
Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.
PLoS One 2019 14(5) e0216417 
[ PubMed ID = 31083672 ] [ RRC reference ]

Hughes S, Brabin C, Appleford PJ, Woollard A.
CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells.
Biol Open 2013 2(7) 718-27 
[ PubMed ID = 23862020 ] [ RRC reference ]

Hajduskova M, Jindra M, Herman MA, Asahina M.
The nuclear receptor NHR-25 cooperates with the Wnt/beta-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans.
J Cell Sci 2009 122(Pt 17) 3051-60 
[ PubMed ID = 19654209 ] [ RRC reference ]

Kagoshima H, Nimmo R, Saad N, Tanaka J, Miwa Y, Mitani S, Kohara Y, Woollard A.
The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal.
Development 2007 134(21) 3905-15 
[ PubMed ID = 17933794 ] [ RRC reference ]