Mutants (Isolated)


Allele Nametm1125
Sequence NameW06B4.3
CGC NameW06B4.3
Worm BaseAllele Name tm1125
CGC Name W06B4.3
Sequence W06B4.3
Phenotypehomozygous viable. Dr. G. Herman: unable to score because of inviablity. Dr. M. Barr: small body size, few dauers observed on starved plate, male mating behavior abnormal. Dr. C. Yang: slightly Dpy, cell corpses degradation defects. Dr. J. Kaplan: Gro, small brood size. Dr. Z. Zhou: persistent cell corpses in adult gonad.
Mutation site703/704-1287/1288 (584 bp deletion)
Putative gene structurejoin(100..878, 1507..1893, 2550..3375, 4221..4614, 5494..6073, 6335..6401)
Map position-4.38
Map position of balancer
Distributed lab
DepositorDr. S. Mitani/NBRP
References Please submit your publication
Li Y, Zhang Y, Gan Q, Xu M, Ding X, Tang G, Liang J, Liu K, Liu X, Wang X, Guo L, Gao Z, Hao X, Yang C.
C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death.
Protein Cell 2018 9(12) 1013-1026 
[ PubMed ID = 29611115 ] [ RRC reference ]

Solinger JA, Spang A.
Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.
Mol Biol Cell 2014 25(24) 3909-25 
[ PubMed ID = 25273556 ] [ RRC reference ]

Wu YE, Huo L, Maeder CI, Feng W, Shen K.
The balance between capture and dissociation of presynaptic proteins controls the spatial distribution of synapses.
Neuron 2013 78(6) 994-1011 
[ PubMed ID = 23727120 ] [ RRC reference ]

Chen D, Jian Y, Liu X, Zhang Y, Liang J, Qi X, Du H, Zou W, Chen L, Chai Y, Ou G, Miao L, Wang Y, Yang C.
Clathrin and AP2 are required for phagocytic receptor-mediated apoptotic cell clearance in Caenorhabditis elegans.
PLoS Genet 2013 9(5) e1003517 
[ PubMed ID = 23696751 ] [ RRC reference ]

Xu M, Liu Y, Zhao L, Gan Q, Wang X, Yang C.
The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.
Mol Biol Cell 2014 25(13) 2071-83 
[ PubMed ID = 24829385 ] [ RRC reference ]

Morris C, Foster OK, Handa S, Peloza K, Voss L, Somhegyi H, Jian Y, Vo MV, Harp M, Rambo FM, Yang C, Hermann GJ.
Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis.
PLoS Genet 2018 14(11) e1007772 
[ PubMed ID = 30419011 ] [ RRC reference ]

Xu J, Sun X, Jing Y, Wang M, Liu K, Jian Y, Yang M, Cheng Z, Yang C.
MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.
Cell Res 2012 22(5) 886-902 
[ PubMed ID = 22212480 ] [ RRC reference ]

Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N, Skolnik EY, Taguchi T, Arai H.
Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis.
Proc Natl Acad Sci U S A 2014 111(11) E978-87 
[ PubMed ID = 24591580 ] [ RRC reference ]

Liu K, Jian Y, Sun X, Yang C, Gao Z, Zhang Z, Liu X, Li Y, Xu J, Jing Y, Mitani S, He S, Yang C.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
J Cell Biol 2016 212(2) 181-98 
[ PubMed ID = 26783301 ] [ RRC reference ]

Delahaye JL, Foster OK, Vine A, Saxton DS, Curtin TP, Somhegyi H, Salesky R, Hermann GJ.
Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.
Mol Biol Cell 2014 25(7) 1073-96 
[ PubMed ID = 24501423 ] [ RRC reference ]

Xiao H, Chen D, Fang Z, Xu J, Sun X, Song S, Liu J, Yang C.
Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans.
Mol Biol Cell 2009 20(1) 21-32 
[ PubMed ID = 18923146 ] [ RRC reference ]