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分譲依頼
株番号 NIES-144
保存機関名 国立環境研究所
門名 Chlorophyta 綱名 Chlorophyceae
目名 科名
学名   Haematococcus lacustris (Girod-Chantrans) Rostafinski
シノニム Volvox lacustris Gir.-Chantr. 1802; Sphaerella lacustris (Gir.-Chantr.) Wittr. ex Hansg. 1888; Lepraria kermesina Wrangel 1824; Sphaerella wrangelii Sommerf. 1824, nom. illeg.; Chlorococcum kermesinum (Wrangel) Fr. 1825; Protococcus kermesinus (Wrangel) C.Agardh 1825; Byssus kermesinum (Wrangel) Wahlenb. 1826; Globulina kermesinum (Wrangel) Turpin 1836; Haematococcus kermesinus (Wrangel) Flot. 1844; Protococcus monospermus Corda 1833; Haematococcus cordae Menegh. 1844; Protosphaeria cordae (Menegh.) Trevis. 1848; Disceraea purpurea Morren & C.Morren 1841; Haematococcus pluvialis Flot. 1844; Protococcus pluvialis (Flot.) Kütz. 1845; Protosphaeria pluvialis (Flot.) Trevis. 1848; Chlamydococcus pluvialis (Flot.) A.Braun 1850 (“1849”); Hysginum pluviale (Flot.) Perty 1852; Sphaerella pluvialis (Flot.) Wittr. 1886; Haematococcus longistigma H.Ettl 1954; Haematococcus buetschlii var. bahusiensis Skuja 1956
一般名 緑藻; ヘマトコッカス
地名（採集年月） 日本  北海道   (1964-07-16)
採集者名  
生息環境（分離源） 淡水
生息環境の詳細   
分離者名(分離年月） 市村輝宜
同定者名 市村輝宜
株の状態 無菌[2013 Jan]; 単藻; クローン
保存形態 凍結保存
凍結保存 不明
培養条件（前培養条件） 培地名:C （寒天）
培地形状:固体
温度:20 (25) ℃
光強度:2 (14-16) μmol phtons/m2/sec  明暗周期:10L:14D
継代培養周期:4 M (14 D)
遺伝子情報 14-3-3 protein (AY973204 ) 18S rRNA (AB360747 ) atpB (AB084325 ) beta-carotene ketolase (D45881 ) bkt3 (AY603347 ) Hsp90 (JN627245 ) idi (AB019034 ) lycopene beta-cyclase (AY182008 ) psaB (AB084365 ) rbcL (AB084336 ) rbcL (AB084337 ) Whole-genome (BLLF00000000 )
画像
特性
  アスタキサンチン生産  ゲノム解読株 (Morimoto et al. 2017); 雌雄同株; 同型配偶
細胞サイズ(min-max) 15μm- 35μm   体制 単細胞性  
注意事項 凍結保存[2016 Apr]; 無菌  

文献
Ichimura, T. & Itoh, T.: 1977: 17. Preservation methods of microalgae (I) [17. Bisaisôrui no hozonhô (I)].: In Preservation methods of microorganisms [Biseibutsu Hozonhô], Ed. by Nei, T., University of Tokyo Press, Tokyo, pp. 355-373 (in Japanese).
Strains: 19 21 22 23 24 27 28 30 31 32 33 34 36 37 38 39 40 41 44 45 46 47 48 49 50 122 123 127 131 144 152 173 175 179 180 181 182 183 185 198 200 203 206 217 226 227 241 266 267 268 295 309 310 334 338 379 436 448 450 455 527

Kajiwara, S., Kakizono, T., Saito, T., Kondo, K., Ohtani, T., Nishio, N., Nagai, S., Misawa, N.: 1995: Isolation and functional identification of a novel cDNA for astaxanthin biosynthesis from Haematococcus pluvialis, and astaxanthin synthesis in Escherichia coli.: Plant Mol. Biol., 29, 343-352.
Strains: 144

Kakizono, T., Kobayashi, M., Nagai, S.: 1992: Effect of carbon/nitrogen ratio on encystment accompanied with astaxanthin formation in a green alga, Haematococcus pluvialis.: J. Ferment. Bioeng., 74, 403-405.
Strains: 144

Kobayashi, M., Hirai, N., Kurimura, Y., Ohigashi, H., Tsuji, Y.: 1997: Abscisic acid-dependent algal morphogenesis in the unicellular green alga Haematococcus pluvialis.: Plant Growth Regulation, 22, 79-85.
Strains: 144

Kobayashi, M., Kakizono, T., Nagai, S.: 1991: Astaxanthin production by a green alga, Haematococcus pluvialis accompanied with morphological changes in acetate media.: J. Ferment. Bioeng., 71, 335-339.
Strains: 144

Kobayashi, M., Kakizono, T., Nagai, S.: 1993: Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis.: Appl. Environ. Microbiol., 59, 867-873.
Strains: 144

Kobayashi, M., Kakizono, T., Nagai, S.: 1993: Photo-dependent astaxanthin biosynthesis in a green alga, Haematococcus pluvialis.: Seibutsu-Kôgaku, 71, 233-237 (in Japanese with English summary).
Strains: 144

Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S.: 1992: Effects of light intensity, light quality, and illumination cycle on astaxanthin formation in a green alga, Haematococcus pluvialis.: J. Ferment. Bioeng., 74, 61-63.
Strains: 144

Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S., Kurimura, Y., Tsuji, Y.: 1997: Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis.: Appl. Microbiol. Biotechnol., 48, 351-356.
Strains: 144

Kobayashi, M., Kakizono, T., Yamaguchi, K., Nishio, N., Nagai, S.: 1992: Growth and asta-xanthin formation of Haematococcus pluvialis in heterotrophic and mixotrophic conditions.: J. Ferment. Bioeng., 74, 17-20.
Strains: 144

Kobayashi, M., Kurimura, Y., Kakizono, T., Nishio, N., Tsuji, Y.: 1997: Morphological changes in the life cycle of the green alga Haematococcus pluvialis.: J. Ferment. Bioeng., 84, 94-97.
Strains: 144

Kobayashi, M., Kurimura, Y., Sakamoto, Y., Tsuji, Y.: 1997: Selective extraction of astaxanthin and chlorophyll from the green alga Haematococcus pluvialis.: Biotechnol. Tech., 11, 657-660.
Strains: 144

Kobayashi, M., Kurimura, Y., Tsuji, Y.: 1997: Light-independent, astaxanthin production by the green microalga Haematococcus pluvialis under salt stress.: Biotechnol. Lett., 19, 507-509.
Strains: 144

Kobayashi, M., Todoroki, Y., Hirai, N., Kurimura, Y., Ohigashi, H., Tsuji, Y.: 1998: Biological activities of abscisic acid analogs in the morphological change of the green alga Haematococcus pluvialis.: J. Ferment. Bioeng., 85, 529-531.
Strains: 144

Mori, F., Erata, M., Watanabe, M. M.: 2002: Cryopreservation of cyanobacteria and green algae in the NIES-Collection.: Microbiol. Cult. Coll., 18, 45-55.
Strains: 19 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 44 45 46 50 51 52 53 54 55 56 58 59 60 61 62 63 64 65 66 67 68 69 70 73 74 75 76 77 78 79 80 81 87 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 119 120 122 123 125 127 128 129 130 131 132 133 134 135 137 138 139 144 147 151 152 153 154 155 156 157 158 159 160 162 163 164 165 166 167 168 170 171 172 173 174 175 176 177 178 179 180 181 182 183 185 186 187 188 189 191 192 193 194 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 224 226 227 228 229 230 231 232 241 242 243 244 245 246 248 257 259 261 262 263 266 267 268 287 288 289 290 294 295 297 298 299 300 301 302 303 305 306 308 309 310 312 313 329 334 337 338 339 340 341 342 349 351 359 360 361 362 375 378 379 380 382 384 385 390 394 396 397 398 415 416 418 419 421 422 423 424 425 426 427 428 429 430 431 432 433 434 436 437 438 439 440 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 464 468 469 474 478 479 480 481 503 504 505 506 507 509 510 512 514 515 522 523 524 527 528 529 530 531 532 536 537 538 539 540 541 542 543 544 545 546 564 565 566 567 568 569 570 571 572 573 574 575 576 577 578 579 580 581 582 583 584 585 592 593 594 595 596 597 598 604 610 628 630 631 632 633 634 635 636 637 638 639 640 641 642 643 644 645 646 647 648 649 650 651 652 653 654 655 656 657 658 659 660 661 662 663 664 665 666 667 672 685 686 687 688 689 690 691 692 693 694 717 718 719 720 721 722 723 724 725 726 727 728 729

Nozaki, H., Onishi, K., Morita, E.: 2002: Differences in pyrenoid morphology are correlated with differences in the rbcL genes of members of the Chloromonas lineage (Volvocales, Chlorophyceae).: J. Mol. Evol., 55, 414-430.
Strains: 96 123 144 213 418 421 425 428 432 439 446 447 456 474 522 564 566 567 569 571 574 582 653 732 851 858 861 875 882 883 968

Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N., Nagai, S.: 1994: Hyper-accumulation of astaxanthin in a green alga Haematococcus pluvialis at elevated temperatures.: Biotechnol. Lett., 16, 133-138.
Strains: 144

Tjahjono, A. E., Kakizono, T., Hayama, Y., Nagai, S.: 1993: Formation and regeneration of protoplast from a unicellular green alga Haematococcus pluvialis.: J. Ferment. Bioeng., 75, 196-200.
Strains: 144

Tjahjono, A. E., Kakizono, T., Hayama, Y., Nishio, N., Nagai S.: 1994: Isolation of resistant mutants against carotenoid biosynthesis inhibitors for a green alga Haematococcus pluvialis, and their hybrid formation by protoplast fusion for breeding of higher astaxanthin producers.: J. Ferment. Bioeng., 77, 352-357.
Strains: 144

Watanabe, M. M., Kasai, F., Hiwatari, T., Suda, S., Nei, T.: 1984: Cryopreservation of microalgae in liquid nitrogen - Survival of algal cultures after freezing.: Jpn. J. Freez. Dry., 30, 23-26 (in Japanese with English title).
Strains: 18 19 21 24 26 29 31 39 40 41 44 45 46 50 73 74 75 76 77 80 81 87 88 89 90 91 93 95 98 99 100 101 120 122 131 135 137 144 151 204 207 213 257 263 379 415 2219 2235 2239 2579

Katsuda, T., Lababpour, A., Shimahara, K., Katoh, S.: 2004: Astaxanthin production by Haematococcus pluvialis under illumination with LEDs.: Enzyme Microb. Technol., 35, 81-86.
Strains: 144

Lababpour, A., Hada, K., Shimahara, K., Katsuda, T., Katoh, S.: 2004: Effects of nutrient supply methods and illumination with blue light emitting diodes (LEDs) on astaxanthin production by Haematococcus pluvialis.: J. Biosci. Bioeng., 98, 452-456.
Strains: 144

Lababpour, A., Shimahara, K., Hada, K., Kyoui, Y., Katsuda, T., Katoh, S.: 2005: Fed-batch culture under illumination with blue light emitting diodes (LEDs) for astaxanthin production by Haematococcus pluvialis.: J. Biosci. Bioeng., 100, 339-342.
Strains: 144

Steinbrenner, J. & Linden, H.: 2003: Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control.: Plant Mol. Biol., 52, 343-356.
Strains: 144

Issarapayup, K., Powtongsook, S., Pavasant, P.: 2009: Flat panel airlift photobioreactors for cultivation of vegetative cells of microalga Haematococcus pluvialis. : J. Biotechnol., 142, 227-232.
Strains: 144

Katsuda, T., Shimahara, K., Shiraishi, H., Yamagami, K., Ranjbar, R., Katoh, S. : 2006: Effect of flashing light from blue light emitting diodes on cell growth and astaxanthin production of Haematococcus pluvialis. : J. Biosci. Bioeng., 102, 442-446.
Strains: 144

Katsuda, T., Shiraishi, H., Ishizu, N., Ranjbar, R., Katoh, S. : 2008: Effect of light intensity and frequency of flashing light from blue light emitting diodes on astaxanthin production by Haematococcus pluvialis. : J. Biosci. Bioeng., 105, 216-220.
Strains: 144

Ranjbar, R., Inoue, R., Katsuda, T., Yamaji, H., Katoh, S. : 2008: High efficiency production of astaxanthin in an airlift photobioreactor. : J. Biosci. Bioeng., 106, 204-207.
Strains: 144

Ranjbar, R., Inoue, R., Shiraishi, H., Katsuda, T., Katoh, S. : 2008: High efficiency production of astaxanthin by autotrophic cultivation of Haematococcus pluvialis in a bubble column photobioreactor. : Biochem. Eng. J., 39, 575-580.
Strains: 144

Yamamoto, H., Hada, K., Yamaji, H., Katsuda, T., Ohno, H., Fukuda, H. : 2006: Application of regularized alternating least squares and independent component analysis to HPLC-DAD data of Haematococcus pluvialis metabolites. : Biochem. Eng. J., 32, 149-156.
Strains: 144

Yoshimura, S., Ranjbar, R., Inoue, R., Katsuda, T., Katoh, S. : 2006: Effective utilization of transmitted light for astaxanthin production by Haematococcus pluvialis. : J. Biosci. Bioeng., 102, 97-101.
Strains: 144

Kunugi, M., Matsumoto, M., Kondo, K. : 2010: Effect of culture conditions on production of useful materials by Haematococcus pluvialis. : Bull. Soc. Sea Water Sci., Jpn, 64, 297-304 (in Japanese with English summary).
Strains: 144

Hu, ZY., Li, YT., Sommerfeld, M., Chen, F., Hu, Q.: 2008: Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae).: Eur. J. Phycol., 43, 365-376.
Strains: 144

Domínguez-Bocanegra, A. R., Legarreta, I. G., Jeronimo, F. M.: 2004: Influence of environmental and nutritional factors in the production of astaxanthin from Haematococcus pluvialis.: Bioresour. Technol., 92, 209-214.
Strains: 144

Steinbrenner, J. & Linden, H.: 2001: Regulation of two carotenoid biosynthesis genes coding for phytoene synthase and carotenoid hydroxylase during stress-induced astaxanthin formation in the green alga Haematococcus pluvialis.: Plant Physiol., 125, 810-817.
Strains: 144

Kang, C.-D., Sim, S.-J.: 2008: Direct extraction of astaxanthin from Haematococcus culture using vegetable oils.: Biotechnol. Lett., 30, 441–444.
Strains: 144

Kang, C. D., Lee, J. S., Park, T. H., Sim, S. J.: 2005: Comparison of heterotrophic and photoautotrophic induction on astaxanthin production by Haematococcus pluvialis.: Appl. Microbiol. Biotechnol., 68, 237-241.
Strains: 144

Shimonaga, T., Konishi, M., Oyama, Y., Fujiwara, S., Satoh, A., Fujita, N., Colleoni, C., Buléon, A., Putaux, J.-L., Ball, S. G., Yokoyma, A., Hara, Y., Nakamura, Y., Tsuzuki, M.: 2008: Variation in Storage α-polyglucans of the Porphyridiales (Rhodophyta).: Plant Cell Physiol., 49, 103-116.
Strains: 18 144 250 530 551 2138 2160 2258 2280

Takaichi, S.: 2011: Carotenoids in algae: distributions, biosyntheses and functions.: Mar. Drugs, 9, 1101-1118.
Strains: 144 1332 3377

Wu, Z.Y., Chen, G.Q., Chong, S.K., Mak, N.-K., Chen, F., Jiang, Y.: 2010: Ultraviolet-B radiation improves astaxanthin accumulation in green microalga Haematococcus pluvialis. : Biotechnol. Lett., 32, 1911-1914.
Strains: 144

Zhang, L., Fan, Y., Shi, F., Qin, S., Liu, B.: 2012: Molecular cloning, characterization, and expression analysis of a cytosolic HSP90 gene from Haematococcus pluvialis.: J. Appl. Phycol., 24, 1601-1612.
Strains: 144

Domínguez-Bocanegra, A. R., Ponce-Noyola, T., Torres-Muñoz, J. A.: 2007: Astaxanthin production by Phaffia rhodozyma and Haematococcus pluvialis: a comparative study.: Appl. Microbiol. Biotechnol., 75, 783-791.
Strains: 144

Hata, N., Ogbonna, J. C., Hasegawa, Y., Taroda, H., Tanaka, H.: 2001: Production of astaxanthin by Haematococcus pluvialis in a sequential heterotrophic-photoautotrophic culture.: J. Appl. Phycol., 13, 395-402.
Strains: 144

Kobayashi, M.: 2000: In vivo antioxidant role of astaxanthin under oxidative stress in the green alga Haematococcus pluvialis.: Appl. Microbilo. Biotechnol., 54, 550-555.
Strains: 144

Kaewpintong, K., Shotipruk, A., Powtongsook, S., Pavasant, P.: 2007: Photoautotrophic high-density cultivation of vegetative cells of Haematococcus pluvialis in airlift bioreactor.: Bioresour. Technol., 98, 288-295.
Strains: 144

Kobayashi, M., Okada, T.: 2000: Protective role of astaxanthin against u.v.-B irradiation in the green alga Haematococcus pluvialis.: Biotechnol. Lett., 22, 177-181.
Strains: 144

Chumpolkulwong, N., Kakizono, T., Ishii, H.: 1997: Enzymatic conversion of b-carotene to astaxanthin by cell-extracts of a green alga Haematococcus pluvialis.: Biotechnol. Lett., 19, 443-446.
Strains: 144

Grewe, C., Griehl, C.: 2008: Time- and media-dependent secondary carotenoid accumulation in Haematococcus pluvialis.: Biotechnol. J., 3, 1232-1244.
Strains: 144

Wan, M., Hou, D., Li, Y., Fan, J., Huang, J., Liang, S., Wang, W., Pan, R., Wang, J., Li, S.: 2014: The effective photoinduction of Haematococcus pluvialis for accumulating astaxanthin with attached cultivation.: Bioresour. Technol., 163, 26-32.
Strains: 144

Issarapayup, K., Powtongsook, S., Pavasant, P.: 2011: Economical review of Haematococcus pluvialis culture in flat-panel airlift photobioreactors.: Aquac. Eng., 44, 65-71.
Strains: 144

Su, Y., Wang, J., Shi, M., Niu, X., Yu, X., Gao, L., Zhang, X., Chen, L., Zhang, W.: 2014: Metabolomic and network analysis of astaxanthin-producing Haematococcus pluvialis under various stress conditions.: Bioresour. Technol., 170, 522-529.
Strains: 144

Liu, J., Gerken, H., Li, Y.: 2014: Single-tube colony PCR for DNA amplification and transformant screening of oleaginous microalgae.: J. Appl. Microbiol., 26, 1719-1726.
Strains: 144

Yoo, J. J., Choi, S. P., Kim, J. Y. H., Chang, W. S., Sim, S. J.: 2013: Development of thin-film photo-bioreactor and its application to outdoor culture of microalgae.: Bioprocess. Biosyst. Eng., 36, 729-736.
Strains: 144

Poonkum, W., Powtongsook, S., Pavasant, P.: 2015: Astaxanthin induction in microalga H. pluvialis with flat panel airlift photobioreactors under indoor and outdoor conditions.: Prep. Biochem. Biotechnol., 45, 1-17.
Strains: 144

Hong, M.-E., Choi, Y. Y., Sim, S. J.: 2016: Effect of red cyst cell inoculation and iron (II) supplementation on autotrophic astaxanthin production by Haematococcus pluvialis under outdoor summer conditions.: J. Biotechnol., 218, 25–33.
Strains: 144

Yoo, J. J., Choi, S. P., Kim, B. W., Sim, S. J.: 2012: Optimal design of scalable photo-bioreactor for phototropic culturing of Haematococcus pluvialis.: Bioprocess. Biosyst. Eng., 35, 309-315.
Strains: 144

Wen, Z., Liu, Z., Hou, Y., Liu, C., Gao, F., Zheng, Y., Chen, F.: 2015: Ethanol induced astaxanthin accumulation and transcriptional expression of carotenogenic genes in Haematococcus pluvialis.: Enzyme Microb. Technol., 78, 10-17.
Strains: 144

Giannelli, L., Yamada, H., Katsuda, T., Yamaji, H.: 2015: Effects of temperature on the astaxanthin productivity and light harvesting characteristics of the green alga Haematococcus pluvialis.: J. Biosci. Bioeng., 119, 345–350.
Strains: 144

Zhang, Z., Wang, B., Hu, Q., Sommerfeld, M., Li, Y., Han, D.: 2016: A new paradigm for producing astaxanthin from the unicellular green alga Haematococcus pluvialis.: Biotech. Bioeng., 113, 2088-2099.
Strains: 144

Kwak, H. S., Kim, J. Y. H., Sim, S. J.: 2015: A microreactor system for cultivation of Haematococcus pluvialis and astaxanthin production.: J. Nanosci. Nanotechnol., 15, 1618-1623.
Strains: 144

Giannelli, L., Yamaji, H., Katsuda, T.: 2015: A numerical model for the quantification of light/dark cycles in microalgal cultures: Air-lift and bubble-column photobioreactor analysis by means of computational fluid dynamics.: J. Chem. Eng. Jpn., 48, 61-71.
Strains: 144

Munakata, H., Nakada, T., Nakahigashi, K., Nozaki, H., Tomita, M.: 2016: Phylogenetic position and molecular chronology of a colonial green flagellate, Stephanosphaera pluvialis (Volvocales, Chlorophyceae), among unicellular algae.: J. Eucaryot. Microbiol., 63, 340-348.
Strains: 123 144 421 428 432 439 446 567 569 571 656 861 887 968 1048 2293 2564 4124 4125

Hong, M. E., Choi, S. P., Park, Y. I., Kim, Y. K., Chang, W. S., Kim, B. W., Sim, S. J.: 2012: Astaxanthin production by a highly photosensitive Haematococcus mutant.: Process Biochem., 47, 1972–1979.
Strains: 144

Lee, T. Y., Praveenkumar, R., Oh, Y. K. Lee, K., Kim, S. H.: 2016: Alginate microgels created by selective coalescence between core drops paired with an ultrathin shell.: J. Mater. Chem. B, 4, 3232-3238.
Strains: 144

Allewaert, C. C., Vanormelingen, P., Daveloose, I., Vyverman, T.: 2017: Intraspecific trait variation affecting astaxanthin productivity in two Haematococcus (Chlorophyceae) species.: Algal Res., 21, 191-202.
Strains: 144

Kiperstok, A. C., Sebestyén, P., Podola, B., Melkonian, M.: 2017: Biofilm cultivation of Haematococcus pluvialis enables a highly productive one-phase process for astaxanthin production using high light intensities.: Algal Res., 21, 213-222.
Strains: 144

Choi, Y. Y., Joun, J. M., Lee, J., Hong, M. E., Pham, H., Chang, W. S., Sim, S. J.: 2017: Development of large-scale and economic pH control system for outdoor cultivation of microalgae Haematococcus pluvialis using industrial flue.: Bioresour. Technol., 244, 1235-1244.
Strains: 144

Lu, Z., Zheng, L., Liu, J., Dai, J., Song, L.: 2019: A novel fed-batch strategy to boost cyst cells production based on the understanding of intracellular carbon and nitrogen metabolism in Haematococcus pluvialis.: Bioresour Technol., 289, 121744 (article ID).
Strains: 144

Choi, YY., Hong, ME., Jin, ES., Woo, HM., Sim, SJ: 2018: Improvement in modular scalability of polymeric thin-film photobioreactor for autotrophic culturing of Haematococcus pluvialis using industrial flue gas.: Bioresour. Technol., 249, 519-526.
Strains: 144

Zhang, C., Chen, G., Wang, Y., Guo, C., Zhou, J.: 2018: Physiological and molecular responses of Prorocentrum donghaiense to dissolved inorganic phosphorus limitation.: Mar. Pollut. Bull., 129, 562-572.
Strains: 144

Lee, C., Jeon, M. S., Vo, T-T., Park, C., Choi, J-S., Kwon, J., Roh, S. W., Choi, Y-E.: 2018: Establishment of a new strategy against Microcystis bloom using newly isolated lytic and toxin-degrading bacteria.: J. Appl. Phycol., 30 1795–1806.
Strains: 144

Sun, P., Cheng, K-W., He, Y., Liu, B., Mao, X., Chen, F.: 2018: Screening and identification of inhibitors of advanced glycation endproduct formation from microalgal extracts.: Food Funct., 9, 1683-1691.
Strains: 144

Hong, M. E.1, Choi, H. I., Kwak, H. S., Hwang, S. W., Sung, Y. J., Chang, W. S., Sim, S. J.: 2018: Rapid selection of astaxanthin-hyperproducing Haematococcus mutant via azide-based colorimetric assay combined with oil-based astaxanthin extraction.: Bioresour. Technol., 267, 175-181.
Strains: 144

Sheng, B., Fan, F., Huang, J. K., Bai, W. M., Wang, J., Li, S. L., Li, W., Wan, M. X., Li, Y. G.: 2018: Investigation on models for light distribution of Haematococcus pluvialis during astaxanthin accumulation stage with an application case.: Algal Res., 33, 182-189.
Strains: 144

Widyaningrum, D., Iida, D., Tanabe, Y., Hayashi, Y., Kurniasih, S. D., Ohama, T.: 2019: Acutely induced cell mortality in the unicellular green alga Chlamydomonas reinhardtii (Chlorophyceae) following exposure to acrylic resin nanoparticles.: J. Phycol., 55, 118-133.
Strains: 35 144 362 418 421 432 438 456 545 571 732 737 858 1022 1048 1848 2150 2169 2201 2202 2208 2209 2212 2280 2352 2462 2578

Lee, C., Ahn, J.-W., Kim, J.-B., Kim, J. Y., Choi, Y.-E.: 2018: Comparative transcriptome analysis of Haematococcus pluvialis on astaxanthin biosynthesis in response to irradiation with red or blue LED wavelength.: World J. Microbiol. Biotechnol., 34, 96 (article ID).
Strains: 144

Choi, H. I., Lee, J. S., Choi, J. W., Shin, Y. S., Sung, Y. J., Hong, M. E., Kwak, H. S., Kim, C. Y., Sim, S. J.: 2019: Performance and potential appraisal of various microalgae as direct combustion fuel.: Bioresour. Technol., 273, 341-349.
Strains: 144

Hiramatsu, K., Ideguchi, T., Yonamine, Y., Lee, S. W., Luo, Y., Hashimoto, K., Ito, T., Hase, M., Park, J.-W., Kasai, Y., Sakuma, S., Hayakawa, T., Arai, F., Hoshino, Y., Goda, K.: 2019: High-throughput label-free molecular fingerprinting flow cytometry.: Sci. Adv., 5, eaau0241 (article ID).
Strains: 48 144 4141

Yokono, M., Takabayashi, A., Kishimoto, J., Fujita, T., Iwai, M., Murakami, A., Akimoto, S., Tanaka, A.: 2019: The PSI-PSII megacomplex in green plants.: Plant Cell Physiol., 60, 1098–1108.
Strains: 144 296 303 2285 2541

Hwang, S. W., Choi, H. I., Sim, S. J.: 2019: Acidic cultivation of Haematococcus pluvialis for improved astaxanthin production in the presence of a lethal fungus.: Bioresour. Technol., 278, 138-144.
Strains: 144

Han, J.-I., Yao, J., Lee, C., Park, J., Choi, Y.-E.: 2019: A novel approach to enhance astaxanthin production in Haematococcus lacustris using a microstructure-based culture platform.: Algal Res., 39, 101464.
Strains: 144

Lee, C., Jeon, M., Kim, J. Y., Lee, S. H., Kim, D. G., Roh, S. W., Choi, Y.-E.: 2019: Effects of an auxin-producing symbiotic bacterium on cell growth of themicroalgaHaematococcus pluvialis: Elevation of cell density andprolongation of exponential stage.: Algal Res., 41, 101547.
Strains: 144

Steinbrenner, J. & Sandmann, G.: 2006: Transformation of the green alga Haematococcus pluvialis with a phytoene desaturase for accelerated astaxanthin biosynthesis.: Appl. Environ. Microbiol., 72, 7477-7484.
Strains: 144

Yoshitomi, T., Shimada, N., Iijima, K., Hashizume, M., Yoshimoto, K.: 2019: Polyethyleneimine-induced astaxanthin accumulation in the green alga Haematococcus pluvialis by increased oxidative stress.: J. Biosci. Bioeng., 128, 751-754.
Strains: 144

Liu, Z., Hou, Y., He, C., Wang, X., Chen, S., Huang, Z., Chen, F.: 2020: Enhancement of linoleic acid content stimulates astaxanthin esterification in Coelastrum sp.: Bioresour. Technol., 300, 122649 (article ID).
Strains: 144

Irshad, M., Myint, A. A., Hong, M. E., Kim, J., Sim, S. J.: 2019: One-pot, simultaneous cell wall disruption and complete extraction of astaxanthin from Haematococcus pluvialis at room temperature.: ACS Sustain. Chem. Eng., 7, 13898-13910.
Strains: 144

Praveenkumar, R., Lee, J., Vijaya, D., Lee, S. Y., Lee, K., Sim, S. J., Hong, M. E., Kim, Y.-E., Oh, Y.-K.: 2020: Morphological change and cell disruption of Haematococcus pluvialis cyst during high-pressure homogenization for astaxanthin recovery.: Appl. Sci., 10, 513 (article ID).
Strains: 144

Butler, T. & Golan, Y.: 2020: Astaxanthin production from microalgae.: In Microalgae biotechnology for food, health and high value products, Eds. by Alam, Md. A., Xu, J-L., Wang, Z., Springer, Singapore, pp. 175-242.
Strains: 144

Azizi, M., Moteshafi, H., Hashemi, M.: 2020: Distinctive nutrient designs using statistical approach coupled with light feeding strategy to improve the Haematococcus pluvialis growth performance and astaxanthin accumulation.: Bioresour. Technol., 300, 122594 (article ID).
Strains: 144

Lu, Z., Dai, J., Zheng, L., Teng, Z., Zhang, Q., Qiu, D., Song, L.: 2020: Disodium 2-oxoglutarate promotes carbon flux into astaxanthin and fatty acid biosynthesis pathways in Haematococcus.: Bioresour. Technol., 299, 122612 (article ID).
Strains: 144

Zhu, J. & Wakisaka, M.: 2019: Effect of air nanobubble water on the growth and metabolism of Haematococcus lacustris and Botryococcus braunii.: J. Nutr. Sci. Vitaminol., 65, S212-S216.
Strains: 144 2199

Widyaningrum, D. & Ohama, T.: 2020: Initial study of polymer-based nanoparticles effect on carotenogenesis of Haematococcus lacustris.: In IOP Conference Series: Earth and Environmental Science, IOP Publishing Ltd, 457, 012035 (article ID).
Strains: 144

Kim, Y. E., Matter, I. A., Lee, N., Jung, M., Lee, Y. C., Choi, S. A., Lee, S. Y., Kim, J. R., Oh, Y. K.: 2020: Enhancement of astaxanthin production by Haematococcus pluvialis using magnesium aminoclay nanoparticles.: Bioresour. Technol., 307, 123270 (article ID).
Strains: 144

Han, S.-I., Chang, S. H., Lee, C., Jeon, M. S., Heo, Y. M., Kim, S.: 2020: Astaxanthin biosynthesis promotion with pH shock in the green microalga, Haematococcus lacustris.: Bioresour. Technol., 314, 123725 (article ID).
Strains: 144

Azizi, M., Moteshafi, H., Hashemi, M.: 2020: A novel CO2 steady feeding based on the pH steady strategy data in the Haematococcus pluvialis cultivation to maximize the cell growth and carbon bio-sequestration.: Bioresour. Technol., 314, 123752 (article ID).
Strains: 144

Tharek, A., Jamaluddin, H., Salleh, M. M., Yahya, N. A., Kaha, M., Hara, H., Iwamoto, K., Mohamad, S. E.: 2020: Astaxanthin production by tropical microalgae strains isolated from environment in Malaysia.: Asian Jr. of Microbiol. Biotech. Env. Sc., 22, 168-173.
Strains: 144

Morimoto, D., Yoshida, T., Sawayama, S.: 2020: Draft genome sequence of the astaxanthin-producing microalga Haematococcus lacustris Strain NIES-144.: Microbiol. Resour. Ann.., 9, e00128-20 (article ID).
Strains: 144

Moon, G., Lee, N., Kang, S., Park, J., Kim, Y.-E., Oh, Y.-K., Chung, S.: 2021: Hydrothermal synthesis of novel two-dimensional α-quartz nanoplates and their applications in energy-saving, high-efficiency, microalgal biorefineries.: Chem. Eng. J., 413, 127467 (article ID).
Strains: 144

Nagarajan, D., Lee, D.-J., Chang, J.: 2018: Heterotrophic microalgal cultivation.: In Bioreactors for microbial biomass and energy conversion, Eds. by Liao Q., Chang J., Herrmann C., Xia A., Springer, Singapore, pp. 117-160.
Strains: 144 227 2280

Patel, A. K., Singhania, R. R., Sim, S. J., Dong, C. D.: 2021: Recent advancements in mixotrophic bioprocessing for production of high value microalgal products.: Bioresour. Technol., 320, 124421 (article ID).
Strains: 144

Khoo, K. S., Lee, S. Y., Ooi, C. W., Fu, X., Miao, X., Ling, T. C., Show, P. L.: 2019: Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis.: Bioresour. Technol., 288, 121606 (article ID).
Strains: 144

Matsuzaki, R., Suzuki, S., Yamaguchi, H., Kawachi, M., Kanesaki, Y., Yoshikawa, H., Mori, T., Nozaki, H.: 2021: The Rubisco small subunits in the green algal genus Chloromonas provide insights into evolutionary loss of the eukaryotic carbon-concentrating organelle, the pyrenoid.: BMC Ecol. Evol., 21, 11 (article ID).
Strains: 144 424 425 2207 2212 2215 2242 2243 2499 3753 4284

Fitriana, H.-N., Lee, S.-Y., Choi, S.-A., Lee, J.-Y., Kim, B.-L., Lee, J.-S., Oh, Y.-K.: 2021: Electric stimulation of astaxanthin biosynthesis in Haematococcus pluvialis.: Appl. Sci., 11, 3384 (article ID).
Strains: 144

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Strains: 24 47 144 2146 2160

Abd Karim, F. F., Mohamad, S. E., Shaza, E. M., Iwamoto, K.: 2021: Initial study on the growth of Haematococus pluvialis for astaxanthin production.: IOP Conf. Ser.: Earth Environ. Sci., 765, 012064 (article ID).
Strains: 144

Cho, S. J., Sung, Y. J., Lee, J. S., Yu, B. S., Sim, S. J.: 2021: Robust cyst germination induction in Haematococcus pluvialis to enhance astaxanthin productivity in a semi-continuous outdoor culture system using power plant flue gas.: Bioresour. Technol., 338, 125533 (article ID).
Strains: 144

Yu, B. S., Sung, Y. J., Choi, H. I., Sirohi, R., Sim, S. J.: 2021: Concurrent enhancement of CO2 fixation and productivities of omega-3 fatty acids and astaxanthin in Haematococcus pluvialis culture via calcium-mediated homeoviscous adaptation and biomineralization.: Bioresour. Technol., 340, 125720 (article ID).
Strains: 144

Sun, H., Wu, T., Chen, H Y., Ren, Y., Yang, S., Huang, J., Mou, H., Chen, F.: 2021: Powerful tools for productivity improvements in microalgal production.: Renew. Sust. Energ. Rev., 152, 111609 (article ID).
Strains: 144 2140 2146

Myint, A. A., Hariyanto, P., Irshad, M., Ruqian, C., Wulandari, S., Hong, M. E., Sim, S. J., Kim, J.: 2022: Strategy for high-yield astaxanthin recovery directly from wet Haematococcus pluvialis without pretreatment.: Bioresour. Technol., 346, 126616 (article ID).
Strains: 144

Lee, N., Narasimhan, A. L., Moon, G., Kim, Y.-E., Park, M., Kim, B., Mahadi, R., Chung, S., Oh, Y.-K.: 2022: Room-temperature cell disruption and astaxanthin recovery from Haematococcus lacustris cysts using ultrathin α-quartz nanoplates and ionic liquids.: Appl. Sci.-Basel, 12, 2210 (article ID).
Strains: 144

Lee, S.-A., Lim, W.-H., Ko, S.-R., Kim, B., Oh, H.-M., Ahn, C.-Y.: 2022: Lifespan extension and anti-oxidant effects of carotenoid pigments in Caenorhabditis elegans.: Bioresour. Technol. Reports, 17, 100962 (article ID).
Strains: 144

Lee, K. H., Chun, Y., Lee, J. H., Park, C., Yoo, H. Y., Kwak, H. S.: 2022: Improved productivity of astaxanthin from photosensitive Haematococcus pluvialis using phototaxis technology.: Mar. Drugs, 20, (article ID).
Strains: 144

Han, S.-I., Jeon, M. S., Ahn, J.-W., Choi, Y.-E.: 2022: Establishment of ultrasonic stimulation to enhance growth of Haematococcus lacustris.: Bioresour. Technol., 360, 127525 (article ID).
Strains: 144

Ueda, R. & MWakisaka, M.: 2022: Effect of melatonin as a bio-stimulant of astaxanthin production from Haematococcus.: J. Jpn. Inst. Energy, 101, 132-137 (in Japanese with English summary).
Strains: 144

Gao, S., Pittman, K., Edmundson, S., Huesemann, M., Greer, M., Louie, W., Chen, P., Nobles, D., Benemann, J., Crowe, B.: 2023: A newly isolated alkaliphilic cyanobacterium for biomass production with direct air CO2 capture.: J. CO2 Util., 69, 102399 (article ID).
Strains: 144

Saito, M., Watanabe, H., Sasaki, M., Ookubo, M., Yarita, T., Shiraiwa, M., Asayama, M.: 2023: Coproduction of lipids and carotenoids by the novel green alga Coelastrella sp. depending on cultivation conditions.: Biotech. Rep., 37, e00769 (article ID).
Strains: 144

Xing, H., Li, Q., Zhao, Y., Gao, H., Li, L., Zhang, Y., Yu, X.: 2023: Exogenous proline boosts the co-accumulation of astaxanthin and biomass in stress-induced Haematococcus pluvialis.: Bioresour. Technol., 369, 128488 (article ID).
Strains: 144 712 797

Joun, J., Sirohi, R., Sim, S. J.: 2023: The effects of acetate and glucose on carbon fixation and carbon utilization in mixotrophy of Haematococcus pluvialis.: Bioresour. Technol., 367, 128218 (article ID).
Strains: 144

Ma, H., Zheng, J., Li, Y., Zhao, L., Zou, S., Hu, Q., Ha,n D.: 2023: A novel bifunctional wax ester synthase involved in early triacylglycerol accumulation in unicellular green microalga Haematococcus pluvialis under high light stress.: Front. Bioeng. Biotechnol., 9, 794714 (article ID).
Strains: 144

Lee, S.-A., Kim, M., Esterhuizen, M., Le, V. V., Kang, M., o, S.-R., Oh, H.-M., Kim, Y. J., Ahn, C.-Y.: 2022: An acceleration of carotenoid production and growth of Haematococcus lacustris induced by host-microbiota network interaction.: Microbiol. Res., 262, 127097 (article ID).
Strains: 144

Mahadi, R., Vahisan, L. P. S., Ilhamsyah, D. P. A., Kim, S., Kim, B., Lee, N., Oh, Y.-K.: 2022: Enhancement of astaxanthin and fatty acid production in Haematococcus pluvialis using strigolactone.: Appl. Sci.-Basel, 12, 1791 (article ID).
Strains: 144

Yoshino, T., Mao, Y., Maeda, Y., Negishi, R., Murata, S., Moriya, S., Shimada, H., Arakaki, A., Kobayashi, K., Hagiwara, Y., Okamoto, K., Tanaka, T.: 2022: Single-cell genotyping of phytoplankton from oceanwater by gel-based cellmanipulation.: Biotechnol. J., 17, 2100633 (article ID).
Strains: 144 385 2145

Velmurugan, A. & Muthukaliannan, G. K.: 2023: Homologous and heterologous expression of phytoene synthase gene in marine microalgae Dunaliella salina and its potential as aquaculture feed.: Aquac. Int., 31, 3125–3144.
Strains: 144

Örs, E. D., Alkan, S. B., Öksüz, A.: 2022: Possible effect of astaxanthin on obesity-related increased COVID-19 infection morbidity and mortality.: Curr. Nutr. Food Sci., 18, 265-273.
Strains: 144

Villanueva, E. M. F. et al.: 2022: Protist.guru: A Comparative Transcriptomics Database for Protists.: J. Mol. Biol., 434, 167502 (article ID).
Strains: 144

Sung, Y. J., Joun, J., Yu, B. S., Sim, S. J.: 2023: Chapter 10 - Photobioreactor systems for production of astaxanthin from microalgae.: In Current Developments in Biotechnology and Bioengineering. Photobioreactors : Design and Applications, Sirohi, R., Pandey, A., Sim, S., Chang, J.-S., Lee, D.-J., Elsevier pp. 229-246.
Strains: 144

Yang, H. E., Yu, B. S., Sim, S. J.: 2023: Enhanced astaxanthin production of Haematococcus pluvialis strains induced salt and high light resistance with gamma irradiation.: Bioresour. Technol., 372, 128651 (article ID).
Strains: 144

Kumar, S., Kumar, R., Diksha, Kumari, A., Panwar, A.: 2022: Astaxanthin: A super antioxidant from microalgae and its therapeutic potential: J. Basic Microbiol., 62, 1064-1082.
Strains: 144