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AVAILABLE MUTANTS (ISOLATED)
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Record No. 892
対立遺伝子 tm892
Sequence Name F20D12.1
CGC Name csr-1
Worm Base 対立遺伝子 tm892
CGC Name csr-1
Sequence F20D12.1
表現型 lethal or sterile. Dr. C. Mello, Cell 127, 747-457 (2006). Dr. E. Miska; Mol Cell 31, 79-90 (2008).
変異部位 26731/26372-27131/27132 (400 bp deletion)
染色体 IV
遺伝子構造 join(25568..26042, 26587..26746, 26788..26941, 26985..27196, 27241..27392, 27440..27825, 27871..28592, 28637..28736, 28781..29137, 29188..29376, 29420..29508, 29555..29651)
マップポジション 3.52
バランサ unc-24 (e138) IV
バランサマップポジション 3.52
プライマー配列 IntFwd:GCCCTGAACATCTTCGGGCT,ExtFwd:GGCCTTTCTCTGCGTTTAGT,ExtRev:CGCAGCGTTTCGGTCAGGAT,IntRev:TCAGGATGAGCAACGTCCAT
変異体送付先
寄託者 Dr. S. Mitani
文献  論文登録
Tyc KM, Nabih A, Wu MZ, Wedeles CJ, Sobotka JA, Claycomb JM.
The Conserved Intron Binding Protein EMB-4 Plays Differential Roles in Germline Small RNA Pathways of C. elegans.
Dev. Cell 2017 42(3) 256-270.e6 
[ PubMed ID = 28787592 ] [ RRCの論文情報 ]

Bharadwaj PS, Hall SE.
.
Genetics 2017 205(4) 1503-1516 
[ PubMed ID = 28122825 ] [ RRCの論文情報 ]

Tu S, Wu MZ, Wang J, Cutter AD, Weng Z, Claycomb JM.
Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes.
Nucleic Acids Res. 2014 43(1) 208-24 
[ PubMed ID = 25510497 ] [ RRCの論文情報 ]

Barberán-Soler S, Fontrodona L, Ribó A, Lamm AT, Iannone C, Cerón J, Lehner B, Valcárcel J.
Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.
Cell Rep 2014 8(6) 1609-1616 
[ PubMed ID = 25220461 ] [ RRCの論文情報 ]

Goh WS, Seah JW, Harrison EJ, Chen C, Hammell CM, Hannon GJ.
A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.
Genes Dev. 2014 28(7) 797-807 
[ PubMed ID = 24696458 ] [ RRCの論文情報 ]

Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A.
Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape.
Nat. Struct. Mol. Biol. 2014 21(4) 358-65 
[ PubMed ID = 24681887 ] [ RRCの論文情報 ]

Kennedy LM, Grishok A.
Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.
Genetics 2014 197(1) 207-20 
[ PubMed ID = 24558261 ] [ RRCの論文情報 ]

Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC.
The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression.
Dev. Cell 2013 27(6) 656-63 
[ PubMed ID = 24360782 ] [ RRCの論文情報 ]

Wedeles CJ, Wu MZ, Claycomb JM.
Protection of germline gene expression by the C. elegans Argonaute CSR-1.
Dev. Cell 2013 27(6) 664-71 
[ PubMed ID = 24360783 ] [ RRCの論文情報 ]

Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.
Cell 2013 155(7) 1532-44 
[ PubMed ID = 24360276 ] [ RRCの論文情報 ]

Hall SE, Chirn GW, Lau NC, Sengupta P.
RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans.
RNA 2013 19(3) 306-19 
[ PubMed ID = 23329696 ] [ RRCの論文情報 ]

Avgousti DC, Palani S, Sherman Y, Grishok A.
CSR-1 RNAi pathway positively regulates histone expression in C. elegans.
EMBO J. 2012 31(19) 3821-32 
[ PubMed ID = 22863779 ] [ RRCの論文情報 ]

Maniar JM, Fire AZ.
EGO-1, a C. elegans RdRP, modulates gene expression via production of mRNA-templated short antisense RNAs.
Curr. Biol. 2011 21(6) 449-59 
[ PubMed ID = 21396820 ] [ RRCの論文情報 ]

Updike DL, Strome S.
A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans.
Genetics 2009 183(4) 1397-419 
[ PubMed ID = 19805813 ] [ RRCの論文情報 ]

Claycomb JM, Batista PJ, Pang KM, Gu W, Vasale JJ, van Wolfswinkel JC, Chaves DA, Shirayama M, Mitani S, Ketting RF, Conte D Jr, Mello CC.
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation.
Cell 2009 139(1) 123-34 
[ PubMed ID = 19804758 ] [ RRCの論文情報 ]

She X, Xu X, Fedotov A, Kelly WG, Maine EM.
Regulation of heterochromatin assembly on unpaired chromosomes during Caenorhabditis elegans meiosis by components of a small RNA-mediated pathway.
PLoS Genet. 2009 5(8) e1000624 
[ PubMed ID = 19714217 ] [ RRCの論文情報 ]