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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 872
対立遺伝子 tm872
Sequence Name D2030.6
CGC Name prg-1
Worm Base 対立遺伝子 tm872
CGC Name prg-1
Sequence D2030.6
表現型 homozygous viable. Dr. C. Mello, Cell 127, 747-457 (2006). Dr. E. Miska; Mol Cell 31, 79-90 (2008).
変異部位 21432/21433-22072/22073 (640 bp deletion)
染色体 I
遺伝子構造 complement(join(20481..20636, 20682..20868, 20915..21152, 21201..21375, 21423..21787, 21834..22275, 22320..22562, 22611..22925, 22975..23328))
マップポジション 2.18
バランサ hT2 [qIs48]
バランサマップポジション
プライマー配列 IntFwd:AGTCGTGGTACAGATCGTAG,ExtRev:GGGATATCTCGCAACGACTA,IntRev:GAGAGGCCGTGGTTCAGGAT,ExtFwd:CTGTAGAGGATCAAGCGGCT
変異体送付先
寄託者 Dr. S. Mitani
文献  論文登録
Leopold LE, Heestand BN, Seong S, Shtessel L, Ahmed S.
Lack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(20) E2667-76 
[ PubMed ID = 25941370 ] [ RRCの論文情報 ]

Barberán-Soler S, Fontrodona L, Ribó A, Lamm AT, Iannone C, Cerón J, Lehner B, Valcárcel J.
Co-option of the piRNA pathway for germline-specific alternative splicing of C. elegans TOR.
Cell Rep 2014 8(6) 1609-16 
[ PubMed ID = 25220461 ] [ RRCの論文情報 ]

Simon M, Sarkies P, Ikegami K, Doebley AL, Goldstein LD, Mitchell J, Sakaguchi A, Miska EA, Ahmed S.
Reduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants.
Cell Rep 2014 7(3) 762-73 
[ PubMed ID = 24767993 ] [ RRCの論文情報 ]

Goh WS, Seah JW, Harrison EJ, Chen C, Hammell CM, Hannon GJ.
A genome-wide RNAi screen identifies factors required for distinct stages of C. elegans piRNA biogenesis.
Genes Dev. 2014 28(7) 797-807 
[ PubMed ID = 24696458 ] [ RRCの論文情報 ]

Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC.
The C. elegans CSR-1 argonaute pathway counteracts epigenetic silencing to promote germline gene expression.
Dev. Cell 2013 27(6) 656-63 
[ PubMed ID = 24360782 ] [ RRCの論文情報 ]

Billi AC, Freeberg MA, Day AM, Chun SY, Khivansara V, Kim JK.
A conserved upstream motif orchestrates autonomous, germline-enriched expression of Caenorhabditis elegans piRNAs.
PLoS Genet. 2013 9(3) e1003392 
[ PubMed ID = 23516384 ] [ RRCの論文情報 ]

Cecere G, Zheng GX, Mansisidor AR, Klymko KE, Grishok A.
Promoters recognized by forkhead proteins exist for individual 21U-RNAs.
Mol. Cell 2012 47(5) 734-45 
[ PubMed ID = 22819322 ] [ RRCの論文情報 ]

Lee HC, Gu W, Shirayama M, Youngman E, Conte D Jr, Mello CC.
C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts.
Cell 2012 150(1) 78-87 
[ PubMed ID = 22738724 ] [ RRCの論文情報 ]

Shirayama M, Seth M, Lee HC, Gu W, Ishidate T, Conte D Jr, Mello CC.
piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline.
Cell 2012 150(1) 65-77 
[ PubMed ID = 22738726 ] [ RRCの論文情報 ]

Billi AC, Alessi AF, Khivansara V, Han T, Freeberg M, Mitani S, Kim JK.
The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs.
PLoS Genet. 2012 8(4) e1002617 
[ PubMed ID = 22548001 ] [ RRCの論文情報 ]

Gent JI, Schvarzstein M, Villeneuve AM, Gu SG, Jantsch V, Fire AZ, Baudrimont A.
A Caenorhabditis elegans RNA-directed RNA polymerase in sperm development and endogenous RNA interference.
Genetics 2009 183(4) 1297-314 
[ PubMed ID = 19805814 ] [ RRCの論文情報 ]

She X, Xu X, Fedotov A, Kelly WG, Maine EM.
Regulation of heterochromatin assembly on unpaired chromosomes during Caenorhabditis elegans meiosis by components of a small RNA-mediated pathway.
PLoS Genet. 2009 5(8) e1000624 
[ PubMed ID = 19714217 ] [ RRCの論文情報 ]

Batista PJ, Ruby JG, Claycomb JM, Chiang R, Fahlgren N, Kasschau KD, Chaves DA, Gu W, Vasale JJ, Duan S, Conte D Jr, Luo S, Schroth GP, Carrington JC, Bartel DP, Mello CC.
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans.
Mol. Cell 2008 31(1) 67-78 
[ PubMed ID = 18571452 ] [ RRCの論文情報 ]

Das PP, Bagijn MP, Goldstein LD, Woolford JR, Lehrbach NJ, Sapetschnig A, Buhecha HR, Gilchrist MJ, Howe KL, Stark R, Matthews N, Berezikov E, Ketting RF, Tavaré S, Miska EA.
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline.
Mol. Cell 2008 31(1) 79-90 
[ PubMed ID = 18571451 ] [ RRCの論文情報 ]

Wang G, Reinke V.
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis.
Curr. Biol. 2008 18(12) 861-7 
[ PubMed ID = 18501605 ] [ RRCの論文情報 ]

Yigit E, Batista PJ, Bei Y, Pang KM, Chen CC, Tolia NH, Joshua-Tor L, Mitani S, Simard MJ, Mello CC.
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.
Cell 2006 127(4) 747-57 
[ PubMed ID = 17110334 ] [ RRCの論文情報 ]