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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 853
対立遺伝子 tm853
Sequence Name T06E4.3
CGC Name atl-1
Worm Base 対立遺伝子 tm853
CGC Name atl-1
Sequence T06E4.3
表現型 Lethal or sterile. Dr. H. Sawa: maternal effect lethal. Dr. M. Hengartner: induction of germ cell death upon genotyoxic stress. Dr. S. Boulton: EMBO J. 24, 4345-4355 (2005). Dr. S. Boulton: EMBO J, 25, 2178-2188 (2006). Dr. A. Higashitani: Genetics 180, 681 (2008).
変異部位 27446/27447-AGCGGGATATACAG-28166/28167 (720 bp deletion + 14 bp insertion)
染色体 V
遺伝子構造 complement(join(19461..19658, 19707..20387, 20436..20561, 20820..21473, 21653..22681, 22730..22861, 22909..23442, 25230..25533, 25582..25874, 25919..26129, 26179..27501, 27546..28624, 28672..28899, 28945..29427, 29476..29555, 29600..29664, 29713..29814, 29862..29935))
マップポジション 2.06
バランサ Not Yet Balanced
バランサマップポジション
プライマー配列 ExtFwd:GAGTCAACTGTCTTGGCTCA,IntFwd:GAAACGTGTATCCCATCGAA,ExtRev:TTCGTCCCGTCTATAGACAA,IntRev:CGAGTCATCGAGAGCTACTT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Moriwaki T, Kato Y, Nakamura C, Ishikawa S, Zhang-Akiyama QM.
A novel DNA damage response mediated by DNA mismatch repair in Caenorhabditis elegans: induction of programmed autophagic cell death in non-dividing cells.
Genes Cancer 2015 6(7-8) 341-55 
[ PubMed ID = 26413217 ] [ RRCの論文情報 ]

Lawrence KS, Chau T, Engebrecht J.
DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.
PLoS Genet. 2015 11(4) e1005150 
[ PubMed ID = 25898113 ] [ RRCの論文情報 ]

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
Nature 2013 501(7467) 416-20 
[ PubMed ID = 23975097 ] [ RRCの論文情報 ]

SenGupta T, Torgersen ML, Kassahun H, Vellai T, Simonsen A, Nilsen H.
Base excision repair AP endonucleases and mismatch repair act together to induce checkpoint-mediated autophagy.
Nat Commun 2013 4 2674 
[ PubMed ID = 24154628 ] [ RRCの論文情報 ]

Spiga FM, Prouteau M, Gotta M.
The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo.
Dev. Biol. 2013 373(1) 26-38 
[ PubMed ID = 23064028 ] [ RRCの論文情報 ]

Woglar A, Daryabeigi A, Adamo A, Habacher C, Machacek T, La Volpe A, Jantsch V.
Matefin/SUN-1 phosphorylation is part of a surveillance mechanism to coordinate chromosome synapsis and recombination with meiotic progression and chromosome movement.
PLoS Genet. 2013 9(3) e1003335 
[ PubMed ID = 23505384 ] [ RRCの論文情報 ]

Vermezovic J, Stergiou L, Hengartner MO, d'Adda di Fagagna F.
Differential regulation of DNA damage response activation between somatic and germline cells in Caenorhabditis elegans.
Cell Death Differ. 2012 19(11) 1847-55 
[ PubMed ID = 22705849 ] [ RRCの論文情報 ]

Aristizábal-Corrales D, Fontrodona L, Porta-de-la-Riva M, Guerra-Moreno A, Cerón J, Schwartz S Jr.
The 14-3-3 gene par-5 is required for germline development and DNA damage response in Caenorhabditis elegans.
J. Cell. Sci. 2012 125(Pt 7) 1716-26 
[ PubMed ID = 22328524 ] [ RRCの論文情報 ]

Rutkowski R, Dickinson R, Stewart G, Craig A, Schimpl M, Keyse SM, Gartner A.
Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.
PLoS Genet. 2011 7(8) e1002238 
[ PubMed ID = 21901106 ] [ RRCの論文情報 ]

Stergiou L, Eberhard R, Doukoumetzidis K, Hengartner MO.
NER and HR pathways act sequentially to promote UV-C-induced germ cell apoptosis in Caenorhabditis elegans.
Cell Death Differ. 2011 18(5) 897-906 
[ PubMed ID = 21151025 ] [ RRCの論文情報 ]

Black JC, Allen A, Van Rechem C, Forbes E, Longworth M, Tschöp K, Rinehart C, Quiton J, Walsh R, Smallwood A, Dyson NJ, Whetstine JR.
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression.
Mol. Cell 2010 40(5) 736-48 
[ PubMed ID = 21145482 ] [ RRCの論文情報 ]

Merlet J, Burger J, Tavernier N, Richaudeau B, Gomes JE, Pintard L.
The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development.
Development 2010 137(22) 3857-66 
[ PubMed ID = 20978077 ] [ RRCの論文情報 ]

Bailly AP, Freeman A, Hall J, Déclais AC, Alpi A, Lilley DM, Ahmed S, Gartner A.
The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.
PLoS Genet. 2010 6(7) e1001025 
[ PubMed ID = 20661466 ] [ RRCの論文情報 ]

Lee SJ, Gartner A, Hyun M, Ahn B, Koo HS.
The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks.
PLoS Genet. 2010 6(1) e1000801 
[ PubMed ID = 20062519 ] [ RRCの論文情報 ]

Penkner AM, Fridkin A, Gloggnitzer J, Baudrimont A, Machacek T, Woglar A, Csaszar E, Pasierbek P, Ammerer G, Gruenbaum Y, Jantsch V.
Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.
Cell 2009 139(5) 920-33 
[ PubMed ID = 19913286 ] [ RRCの論文情報 ]

Greiss S, Hall J, Ahmed S, Gartner A.
C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis.
Genes Dev. 2008 22(20) 2831-42 
[ PubMed ID = 18923081 ] [ RRCの論文情報 ]

Mori C, Takanami T, Higashitani A.
Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.
Genetics 2008 180(1) 681-6 
[ PubMed ID = 18716329 ] [ RRCの論文情報 ]

Budirahardja Y, Gönczy P.
PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos.
Development 2008 135(7) 1303-13 
[ PubMed ID = 18305005 ] [ RRCの論文情報 ]

Youds JL, Barber LJ, Ward JD, Collis SJ, O'Neil NJ, Boulton SJ, Rose AM.
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair.
Mol. Cell. Biol. 2008 28(5) 1470-9 
[ PubMed ID = 18086896 ] [ RRCの論文情報 ]

Zermati Y, Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL, Rosselli F, D'Amelio M, Amendola R, Castedo M, Hengartner M, Soria JC, Cecconi F, Kroemer G.
Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.
Mol. Cell 2007 28(4) 624-37 
[ PubMed ID = 18042457 ] [ RRCの論文情報 ]

Ward JD, Barber LJ, Petalcorin MI, Yanowitz J, Boulton SJ.
Replication blocking lesions present a unique substrate for homologous recombination.
EMBO J. 2007 26(14) 3384-96 
[ PubMed ID = 17611606 ] [ RRCの論文情報 ]

Stergiou L, Doukoumetzidis K, Sendoel A, Hengartner MO.
The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans.
Cell Death Differ. 2007 14(6) 1129-38 
[ PubMed ID = 17347667 ] [ RRCの論文情報 ]

Collis SJ, Barber LJ, Ward JD, Martin JS, Boulton SJ.
C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair.
DNA Repair (Amst.) 2006 5(11) 1398-406 
[ PubMed ID = 16914393 ] [ RRCの論文情報 ]

Polanowska J, Martin JS, Garcia-Muse T, Petalcorin MI, Boulton SJ.
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.
EMBO J. 2006 25(10) 2178-88 
[ PubMed ID = 16628214 ] [ RRCの論文情報 ]

Garcia-Muse T, Boulton SJ.
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.
EMBO J. 2005 24(24) 4345-55 
[ PubMed ID = 16319925 ] [ RRCの論文情報 ]