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Record No. 544
対立遺伝子 tm544
Sequence Name C06A1.1
CGC Name cdc-48.1
Worm Base 対立遺伝子 tm544
CGC Name cdc-48.1
Sequence C06A1.1
表現型 homozygous viable. Dr. T. Ogura: BBRC 345, 746-753 (2006). Genes to Cells: 12, 1063 (2007). Dr. T. Hoppe: J. Struct. Biol. 156, 41 (2006), Nat. Cell Biol. 9, 379 (2007).
変異部位 3193/3194-3861/3862 (668 bp deletion)
染色体 II
遺伝子構造 complement(join(1127..1262,1312..1506,1762..2834, 2881..3708,3987..4184))
マップポジション 3.11
バランサ
バランサマップポジション
プライマー配列 IntRev:CCAACGCATCAAAGCGAAAA,ExtRev:ACATAATGGCCTCGGTTCCA,ExtFwd:CATCGAAGAACAACACGCAA,IntFwd:CACGAGCCTTGTCGAAGACA
変異体送付先
寄託者 Dr. S. Mitani
文献  論文登録
Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG.
Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance.
J Neurosci. 2015 35(42) 14286-306 
[ PubMed ID = 26490867 ] [ RRCの論文情報 ]

Murayama Y, Ogura T, Yamanaka K.
Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.
Biochem. Biophys. Res. Commun. 2015 459(1) 154-60 
[ PubMed ID = 25721663 ] [ RRCの論文情報 ]

Marza E, Taouji S, Barroso K, Raymond AA, Guignard L, Bonneu M, Pallares-Lupon N, Dupuy JW, Fernandez-Zapico ME, Rosenbaum J, Palladino F, Dupuy D, Chevet E.
Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.
EMBO Rep. 2015 16(3) 332-40 
[ PubMed ID = 25652260 ] [ RRCの論文情報 ]

Zou CG, Ma YC, Dai LL, Zhang KQ.
Autophagy protects C. elegans against necrosis during Pseudomonas aeruginosa infection.
Proc. Natl. Acad. Sci. U.S.A. 2014 111(34) 12480-5 
[ PubMed ID = 25114220 ] [ RRCの論文情報 ]

Segref A, Kevei É, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T.
Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.
Cell Metab. 2014 19(4) 642-52 
[ PubMed ID = 24703696 ] [ RRCの論文情報 ]

Sasagawa Y, Higashitani A, Urano T, Ogura T, Yamanaka K.
CDC-48/p97 is required for proper meiotic chromosome segregation via controlling AIR-2/Aurora B kinase localization in Caenorhabditis elegans.
J Struct Biol. 2012 179(2) 104-11 
[ PubMed ID = 22735043 ] [ RRCの論文情報 ]

McMullen PD, Aprison EZ, Winter PB, Amaral LA, Morimoto RI, Ruvinsky I.
Macro-level modeling of the response of C. elegans reproduction to chronic heat stress.
PLoS Comput. Biol. 2012 8(1) e1002338 
[ PubMed ID = 22291584 ] [ RRCの論文情報 ]

Franz A, Orth M, Pirson PA, Sonneville R, Blow JJ, Gartner A, Stemmann O, Hoppe T.
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
Mol. Cell 2011 44(1) 85-96 
[ PubMed ID = 21981920 ] [ RRCの論文情報 ]

Liu G, Rogers J, Murphy CT, Rongo C.
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan.
EMBO J. 2011 30(15) 2990-3003 
[ PubMed ID = 21673654 ] [ RRCの論文情報 ]

Segref A, Torres S, Hoppe T.
A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.
Genetics 2011 187(4) 1235-40 
[ PubMed ID = 21288877 ] [ RRCの論文情報 ]

Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T.
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
Nat. Cell Biol. 2011 13(3) 273-81 
[ PubMed ID = 21317884 ] [ RRCの論文情報 ]

Sasagawa Y, Yamanaka K, Saito-Sasagawa Y, Ogura T.
Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.
Genes Cells 2010 15(12) 1201-15 
[ PubMed ID = 20977550 ] [ RRCの論文情報 ]

Sasagawa Y, Otani M, Higashitani N, Higashitani A, Sato K, Ogura T, Yamanaka K.
Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.
J Cell Sci. 2009 122(Pt 20) 3663-72 
[ PubMed ID = 19773360 ] [ RRCの論文情報 ]

Rodrigues AJ, Neves-Carvalho A, Ferro A, Rokka A, Corthals G, Logarinho E, Maciel P.
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
Biochem. Biophys. Res. Commun. 2009 386(4) 575-81 
[ PubMed ID = 19545544 ] [ RRCの論文情報 ]

Arur S, Ohmachi M, Nayak S, Hayes M, Miranda A, Hay A, Golden A, Schedl T.
Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development.
Proc. Natl. Acad. Sci. U.S.A. 2009 106(12) 4776-81 
[ PubMed ID = 19264959 ] [ RRCの論文情報 ]

Caruso ME, Jenna S, Bouchecareilh M, Baillie DL, Boismenu D, Halawani D, Latterich M, Chevet E.
GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.
Mol. Cell. Biol. 2008 28(13) 4261-74 
[ PubMed ID = 18458060 ] [ RRCの論文情報 ]

Sasagawa Y, Yamanaka K, Ogura T.
ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
Genes Cells 2007 12(9) 1063-73 
[ PubMed ID = 17825049 ] [ RRCの論文情報 ]

Janiesch PC, Kim J, Mouysset J, Barikbin R, Lochmüller H, Cassata G, Krause S, Hoppe T.
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.
Nat. Cell Biol. 2007 9(4) 379-90 
[ PubMed ID = 17369820 ] [ RRCの論文情報 ]

Mouysset J, Kähler C, Hoppe T.
A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation.
J Struct Biol. 2006 156(1) 41-9 
[ PubMed ID = 16647269 ] [ RRCの論文情報 ]

Yamauchi S, Yamanaka K, Ogura T.
Comparative analysis of expression of two p97 homologues in Caenorhabditis elegans.
Biochem. Biophys. Res. Commun. 2006 345(2) 746-53 
[ PubMed ID = 16701565 ] [ RRCの論文情報 ]