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AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 4525
対立遺伝子 tm4525
Sequence Name ZC376.7
CGC Name atfs-1
Worm Base 対立遺伝子 tm4525
CGC Name atfs-1
Sequence ZC376.7
表現型 homozygous viable.
変異部位 25767/25768-GAAAAAT-26199/26200 (432 bp deletion + 7 bp insertion)
染色体 V
遺伝子構造 join(25621..25716, 25771..25841, 25891..26266, 27353..27424, 27477..27557, 27691..28343, 28442..28559)
マップポジション 6.2
バランサ
バランサマップポジション
プライマー配列 IntRev:TCCCGTACCATATTATCTCC,ExtRev:GTCGGCAATGCGAAAAAGAT,IntFwd:ATCCCCATAATGGTTCGCTG,ExtFwd:CACTGCCAATGTGAGTCATG
変異体送付先
寄託者 Dr. S. Mitani
文献  論文登録
Gitschlag BL, Kirby CS, Samuels DC, Gangula RD, Mallal SA, Patel MR.
Homeostatic Responses Regulate Selfish Mitochondrial Genome Dynamics in C. elegans.
Cell Metab. 2016 24(1) 91-103 
[ PubMed ID = 27411011 ] [ RRCの論文情報 ]

Köhler F, Müller-Rischart AK, Conradt B, Rolland SG.
The loss of LRPPRC function induces the mitochondrial unfolded protein response.
Aging (Albany NY) 2015 7(9) 701-17 
[ PubMed ID = 26412102 ] [ RRCの論文情報 ]

Govindan JA, Jayamani E, Zhang X, Mylonakis E, Ruvkun G.
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans.
Proc. Natl. Acad. Sci. U.S.A. 2015 112(40) 12456-61 
[ PubMed ID = 26392561 ] [ RRCの論文情報 ]

Kaufman DM, Crowder CM.
Mitochondrial Proteostatic Collapse Leads to Hypoxic Injury.
Curr. Biol. 2015 25(16) 2171-6 
[ PubMed ID = 26234215 ] [ RRCの論文情報 ]

Nargund AM, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM.
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
Mol. Cell 2015 58(1) 123-33 
[ PubMed ID = 25773600 ] [ RRCの論文情報 ]

Pellegrino MW, Nargund AM, Kirienko NV, Gillis R, Fiorese CJ, Haynes CM.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
Nature 2014 516(7531) 414-7 
[ PubMed ID = 25274306 ] [ RRCの論文情報 ]

Liu Y, Samuel BS, Breen PC, Ruvkun G.
Caenorhabditis elegans pathways that surveil and defend mitochondria.
Nature 2014 508(7496) 406-10 
[ PubMed ID = 24695221 ] [ RRCの論文情報 ]

Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M.
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans.
Nat Commun 2014 5 3483 
[ PubMed ID = 24662282 ] [ RRCの論文情報 ]

Rainbolt TK, Atanassova N, Genereux JC, Wiseman RL.
Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation.
Cell Metab. 2013 18(6) 908-19 
[ PubMed ID = 24315374 ] [ RRCの論文情報 ]

Baker BM, Nargund AM, Sun T, Haynes CM.
Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.
PLoS Genet. 2012 8(6) e1002760 
[ PubMed ID = 22719267 ] [ RRCの論文情報 ]

Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM.
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.
Science 2012 337(6094) 587-90 
[ PubMed ID = 22700657 ] [ RRCの論文情報 ]