HOME MUTANTS CRE TRANSGENIC BALANCER PROMOTER SEARCH FAQ & CONTACT
ミニアンケート集計結果はこちら     MUTANTS
キーワード検索
分離済み変異体
スクリーニング中変異体
  

分離済み変異体
変異体一覧
項目検索
分譲申し込み方法
MTA
技術的なコメント
論文情報登録

スクリーニング中変異体
進行状況
スクリーニング申し込み方法
スクリーニング申し込み

フィードバック
フィードバックの
お願い
 
 
 

Last Update
null

 
staff only
AVAILABLE MUTANTS (ISOLATED)
 変異体 To English >>
 
Record No. 420
対立遺伝子 tm420
Sequence Name W06D12.3
CGC Name fat-5
Worm Base 対立遺伝子 tm420
CGC Name fat-5
Sequence W06D12.3
表現型 homozygous viable. Dr. H. Arai: WT (Brood size, embryonic lethality, larval lehtality, growth rate), Dr. M. Han: slow growth, dumpish, mono-unsaturated fatty acids N17 are decreased. Dr. K. Sakamoto: J. Biochem 144, 149 (2008). Dr. J. Watts & Dr. J. Browse: PLoS Genetics 2, e108 (2006), Genetics 176, 865 (2007).
変異部位 19998/19999-20777/20778 (779 bp deletion)
染色体 V
遺伝子構造 join(19946..20159, 20215..20551, 21208..21658)
マップポジション 13.08
バランサ
バランサマップポジション
プライマー配列 ExtFwd:TCACACAACTTGTTTGCCTC,IntFwd:ACAGACTCCGCCCCTTCTTT,IntRev:CGACCGAATTTTGGGCAAAA,ExtRev:GGATTGGCCTAGCCCAAACT
変異体送付先
寄託者 Dr. S. Mitani/NBRP
文献  論文登録
Garcia AM, Ladage ML, Dumesnil DR, Zaman K, Shulaev V, Azad RK, Padilla PA.
Glucose induces sensitivity to oxygen deprivation and modulates insulin/IGF-1 signaling and lipid biosynthesis in Caenorhabditis elegans.
Genetics 2015 200(1) 167-84 
[ PubMed ID = 25762526 ] [ RRCの論文情報 ]

Wang P, Liu B, Zhang D, Belew MY, Tissenbaum HA, Cheng JX.
Imaging lipid metabolism in live Caenorhabditis elegans using fingerprint vibrations.
Angew. Chem. Int. Ed. Engl. 2014 53(44) 11787-92 
[ PubMed ID = 25195517 ] [ RRCの論文情報 ]

Vásquez V, Krieg M, Lockhead D, Goodman MB.
Phospholipids that contain polyunsaturated fatty acids enhance neuronal cell mechanics and touch sensation.
Cell Rep 2014 6(1) 70-80 
[ PubMed ID = 24388754 ] [ RRCの論文情報 ]

Erkut C, Vasilj A, Boland S, Habermann B, Shevchenko A, Kurzchalia TV.
Molecular strategies of the Caenorhabditis elegans dauer larva to survive extreme desiccation.
PLoS ONE 2013 8(12) e82473 
[ PubMed ID = 24324795 ] [ RRCの論文情報 ]

Shi X, Li J, Zou X, Greggain J, Rødkær SV, Færgeman NJ, Liang B, Watts JL.
Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase.
J. Lipid Res. 2013 54(9) 2504-14 
[ PubMed ID = 23787165 ] [ RRCの論文情報 ]

Bettinger JC, Leung K, Bolling MH, Goldsmith AD, Davies AG.
Lipid environment modulates the development of acute tolerance to ethanol in Caenorhabditis elegans.
PLoS ONE 2012 7(5) e35192 
[ PubMed ID = 22574115 ] [ RRCの論文情報 ]

Castro C, Sar F, Shaw WR, Mishima M, Miska EA, Griffin JL.
A metabolomic strategy defines the regulation of lipid content and global metabolism by Δ9 desaturases in Caenorhabditis elegans.
BMC Genomics 2012 13 36 
[ PubMed ID = 22264337 ] [ RRCの論文情報 ]

Savory FR, Sait SM, Hope IA.
DAF-16 and Δ9 desaturase genes promote cold tolerance in long-lived Caenorhabditis elegans age-1 mutants.
PLoS ONE 2011 6(9) e24550 
[ PubMed ID = 21931751 ] [ RRCの論文情報 ]

Goudeau J, Bellemin S, Toselli-Mollereau E, Shamalnasab M, Chen Y, Aguilaniu H.
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans.
PLoS Biol. 2011 9(3) e1000599 
[ PubMed ID = 21423649 ] [ RRCの論文情報 ]

Marsh EK, van den Berg MC, May RC.
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
PLoS ONE 2011 6(3) e16839 
[ PubMed ID = 21399680 ] [ RRCの論文情報 ]

Horikawa M, Sakamoto K.
Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans.
Mol. Cell. Endocrinol. 2010 323(2) 183-92 
[ PubMed ID = 20226839 ] [ RRCの論文情報 ]

Le TT, Duren HM, Slipchenko MN, Hu CD, Cheng JX.
Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans.
J. Lipid Res. 2009 51(3) 672-7 
[ PubMed ID = 19776402 ] [ RRCの論文情報 ]

Brock TJ, Browse J, Watts JL.
Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans.
Genetics 2007 176(2) 865-75 
[ PubMed ID = 17435249 ] [ RRCの論文情報 ]

Murray P, Hayward SA, Govan GG, Gracey AY, Cossins AR.
An explicit test of the phospholipid saturation hypothesis of acquired cold tolerance in Caenorhabditis elegans.
Proc. Natl. Acad. Sci. U.S.A. 2007 104(13) 5489-94 
[ PubMed ID = 17369360 ] [ RRCの論文情報 ]

Brock TJ, Browse J, Watts JL.
Genetic regulation of unsaturated fatty acid composition in C. elegans.
PLoS Genet. 2006 2(7) e108 
[ PubMed ID = 16839188 ] [ RRCの論文情報 ]